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1,337 results for “inflammatory disease”
Biohybrid microrobots regulate colonic cytokine and epithelium barrier in inflammatory bowel disease
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Data from: Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
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Data from: Humoral immune responses against gut bacteria In dogs with inflammatory bowel disease
Inflammatory bowel disease (IBD) in dogs is associated with clinical signs of intestinal dysfunction, as well as abnormal lymphocytic and myeloid cell infiltrates in the small and/or large intestine. Thus, in many respects IBD in dogs resembles IBD in humans. However, the factors that trigger intestinal inflammation in dogs with IBD are not well understood and have been variously attributed to immune responses against dietary antigens or intestinal antigens. Previous studies in humans with IBD have documented increased production of IgG and IgA antibodies specific to intestinal bacteria, and this abnormal immune response has been linked to disease pathogenesis. Therefore, we investigated the humoral immune response against gut bacteria in dogs with IBD, using flow cytometry to quantitate IgG and IgA binding. Studies were also done to investigate the source of these antibodies (locally produced versus systemic production) and whether greater antibody binding to bacteria is associated with increased inflammatory responses. We found that dogs with IBD had significantly higher percentages and overall amounts of IgG bound to their intestinal bacteria compared to healthy dogs. Similarly, significantly higher percentages of bacteria were IgA+ bacteria were also found in dogs with IBD. Serum antibody recognition of gut bacteria was not different between healthy dogs and dogs with IBD, suggesting that anti-bacterial antibodies were primarily produced locally in the gut rather than systemically. Importantly, bacteria in the Actinobacteria phylum and in particular the genus Collinsella had significantly greater levels of antibody binding in dogs with IBD. Based on these findings, we concluded that antibody binding to commensal gut bacteria was significantly increased in dogs with IBD, that particular phyla were preferential targets for gut antibodies, and that anti-bacterial antibody responses may play an important role in regulating gut inflammation.
Data from: An objective in vivo diagnostic method for inflammatory bowel disease
Inflammatory damage to the bowel, as occurs in inflammatory bowel disease (IBD), is debilitating to patients. In both patients and animal experimental models histological analysis of biopsies and endoscopic examinations are used to evaluate the disease state. However such measurements often have delays and are invasive, while endoscopy is not quantitatively objective. Therefore, a real-time quantitative method to assess compromised mucosal barrier function is advantageous. We investigated the correlation of in vivo changes in electrical transmural impedance with histological measures of inflammation. Four platinum (Pt) ball electrodes were placed in the lumen of the rat small intestine, with a return electrode under the skin. Electrodes placed within the non-inflamed intestine generated stable impedances during the 3 h testing period. Following intraluminal injection of 2,4,6-trinitrobenzene sulphonic acid (TNBS), an established animal model of IBD, impedances in the inflamed region significantly decreased relative to a region not exposed to TNBS (P < 0.05). Changes in intestinal transmural impedance were correlated (P < 0.05) with histologically assessed damage to the mucosa and increases in neutrophil, eosinophil and T-cell populations at 3 h compared with tissue from control regions. This quantitative, real-time assay may have application in the diagnosis and clinical management of IBD.
scRNA-seq data for "Bacteroides fragilis toxin suppresses METTL3-Mediated m6A modification in macrophage to promote inflammatory bowel disease"
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Effects of inhaled double-branch dilator Umeclidinium/Vilanterol on pulmonary function and inflammatory factors in patients with stable chronic obstructive pulmonary disease
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Minimum dataset and R-script for analysis of inflammatory proteins associated with risk of Coronary Artery Disease in type 1 diabetes patients
<p>Data for CAD manuscript</p>
Tofacitinib for Inflammatory Eye Disease
ClinicalTrials.gov study NCT03580343. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evolution of Fatigue in Patients With Inflammatory Bowel Disease
ClinicalTrials.gov study NCT04189692. IPD Sharing: NO. Countries: 0. Publications: 2.
Stem Cell Transplantation in Idiopathic Inflammatory Myopathy Diseases
ClinicalTrials.gov study NCT00278564. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparing the Accuracy of Different Ultrasound-based Scores to Assess Disease Severity in Patients with Inflammatory Bowel Disease
ClinicalTrials.gov study NCT06705972. IPD Sharing: NO. Countries: 0. Publications: 5.
Study of the Relationship Between Glycogen Storage Disease Type Ia and Inflammatory Bowel Disease
ClinicalTrials.gov study NCT01854242. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of KPI-121 in Subjects With Inflammatory Meibomian Gland Disease
ClinicalTrials.gov study NCT02218489. IPD Sharing: Not stated. Countries: 1. Publications: 0.
LANDSCAPE: Demographics and Treatment Patterns of Patients With Immune-Mediated Inflammatory Skin Diseases in Italian Clinical Practice
ClinicalTrials.gov study NCT07336641. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Assessment of Nutritional Knowledge in Patients With Inflammatory Bowel Disease
ClinicalTrials.gov study NCT04882566. IPD Sharing: NO. Countries: 0. Publications: 3.
Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease
ClinicalTrials.gov study NCT03762824. IPD Sharing: UNDECIDED. Countries: 0. Publications: 6.
The Effect of Joint Transition Visits on Quality of Life in Inflammatory Bowel Diseases (TRANS-IBD)
ClinicalTrials.gov study NCT04290156. IPD Sharing: NO. Countries: 0. Publications: 7.
Electronic Health Record (EHR)-Based Intervention for Gastroesophageal Reflux Disease (GERD) and Chronic Non-steroidal Anti-inflammatory Drug (NSAID) Use
ClinicalTrials.gov study NCT00691171. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Diagnosis of Inflammatory Bowel Disease
ClinicalTrials.gov study NCT07400211. IPD Sharing: UNDECIDED. Countries: 0. Publications: 16.
Manitoba Inflammatory Bowel Disease Cohort Study
ClinicalTrials.gov study NCT03262649. IPD Sharing: NO. Countries: 0. Publications: 60.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.