Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
3,900
datasets available to search
ShareScore release 0.9.0
Dataset results
3,900 results for “parkinsonism”
Efficacy of a multiple-component and multifactorial personalized fall prevention program in a mixed population of community-dwelling older adults with stroke, Parkinson's disease, or frailty compared to usual care: The PRE.C.I.S.A. Randomized Controlled Trial
<p>Raw data associated with the scientific publication 'Efficacy of a multiple-component and multifactorial personalized fall prevention program in a mixed population of community-dwelling older adults with stroke, Parkinson’s disease, or frailty compared to usual care: The PRE.C.I.S.A. Randomized Controlled Trial'.</p>
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease
<p>Supplementary datasets (Supplementary tables 1 to 10)</p>
Protein aggregation and calcium dysregulation are the earliest hallmarks of familial Parkinson's disease in human midbrain dopaminergic neurons
<p>Mutations in the <em>SNCA</em> gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an <em>SNCA</em> mutation during development, to end stage pathology is unknown. Utilising human induced pluripotent stem cells (hiPSCs), we resolved the temporal sequence of SNCA induced pathophysiological events in order to discover early, and likely causative, events. Our small molecule-based protocol generates highly enriched midbrain dopaminergic (mDA) neurons: molecular identity was confirmed using single-cell RNA sequencing and proteomics, and functional identity through dopamine synthesis, and measures of electrophysiological activity. At the earliest stage of differentiation, prior to maturation to mDA neurons, we demonstrate the initial formation of small β-sheet rich oligomeric aggregates, in <em>SNCA</em>-mutant cultures. Aggregation persists and progresses, ultimately resulting in the accumulation of phosphorylated aggregates. Impaired intracellular calcium signalling, increased basal calcium, and impairments in mitochondrial calcium handling occurred early at day 34-41 post differentiation. Once midbrain identity fully developed, at day 48-62 post differentiation, <em>SNCA</em>-mutant neurons exhibited mitochondrial dysfunction, oxidative stress, lysosomal swelling and increased autophagy. Ultimately these multiple cellular stresses lead to abnormal excitability, altered neuronal activity, and cell death. Our differentiation paradigm generates an efficient model for studying disease mechanisms in PD, and highlights that protein misfolding to generate intraneuronal oligomers is one of the earliest critical events driving disease in human neurons, rather than a late-stage hallmark of the disease.</p>
Directional control of neurite outgrowth: emerging technologies for Parkinson's Disease using magnetic nanoparticles and magnetic field gradients
<p>Data set for publication '<strong>Directional control of neurite outgrowth: emerging technologies for Parkinson’s Disease using magnetic nanoparticles and magnetic field gradients'</strong></p> <p><strong>Journal of The Royal Society Interface</strong></p> <p><strong>2022</strong></p>
Deep Brain Stimulation in Parkinson's Disease – Current State, Future Prospects and the role of Artificial Intelligence
Open the record for dataset details and reuse information.
A Systematic Review and Bayesian Meta-Analysis of Acoustic Measures of Prosody in Parkinson's Disease
<p>The folder contains the dataset used for this study and a file defining the titles of the dataset.</p> <div> <div> <div> </div> <div> <div> <div> </div> <div> <p> </p> <p> </p> </div> </div> </div> </div> </div>
Supplemental files associated with the the manuscript "Genetic screening and metabolomics identify glial adenosine metabolism as a therapeutic target in Parkinson's disease"
Open the record for dataset details and reuse information.
Master Thesis Parkinson desease Dataset
<p>Dataset containing result from my master thesis work described in the following github repo : https://github.com/luca-farinola/Master_Thesis-Neurodevelopmental_trajectory_PD</p>
Parkinson's Disease MAGMA Analysis Ranked Genes
Open the record for dataset details and reuse information.
Data associated to the study entitled:"Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson's disease evaluated with multimodal MRI"
<p>Parkinson’s disease is characterized by neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta. The 6-hydroxydopamine (6-OHDA) rat model has been used to study neurodegeneration in the nigro-striatal dopaminergic system. The goal of this study was to evaluate the reliability of diffusion MRI and resting-state functional MRI biomarkers in monitoring neurodegeneration in the 6-OHDA rat model assessed by quantitative histology.</p> <p>We performed a unilateral injection of 6-OHDA in the striatum of Sprague Dawley rats to produce retrograde degeneration of the dopamine neurons in the substantia nigra pars compacta. We carried out a longitudinal study with a multi-modal approach combining structural and functional MRI together with quantitative histological validation to follow the effects of the lesion. Functional and structural connectivity were assessed in the brain of 6-OHDA rats and sham rats (NaCl injection) at 3 and 6 weeks post-lesioning using resting-state functional MRI and diffusion-weighted.</p> <p>The shared datafile corresponds to the MRI biomarkers extracted from diffusion and functional acquisitions as well as from histological mesaurements within striatum and substantia nigria.</p>
Mãos que Vibram - Canal Mãos que Vibram: um olhar para a doença de Parkinson
<p>O <strong>Canal Mãos que Vibram</strong> é uma iniciativa voltada para fornecer informações atualizadas e relevantes sobre a doença de Parkinson. Criado em parceria com a UniAraguaia e a ASPARK-GO, este canal tem como objetivo conscientizar e educar sobre a doença, oferecendo conteúdo de qualidade de forma acessível.</p>
Synthetic ECG Database of Antegrade Accessory Pathway Locations and Timings in Wolff-Parkinson-White syndrome
<p>A synthetic database of 12 lead electrocardiograms (ECGs) was generated by varying locations and timings of antegrade accessory pathways (APs) within Wolff-Parkinson-White syndrome. The ECGs were generated within a <a href="https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.907190/full">virtual model of whole-heart electrophysiology</a> of a single male patient that had been previously personalized to a clinical 12 lead ECG under normal sinus rhythm. The dataset consists of a total of 9271 ECGs, each corresponding to an APs sampled throughout both ventricles. The database is split into LV ( 4678 ECGs ) and RV (4593 ECGs) datasets for subsequent processing. Sampling CSV files are provided for both LV and RV datasets. </p>
Data from: Axial symptoms predict mortality in patients with Parkinson disease with subthalamic stimulation
Objective: To characterize how disease progression is associated with mortality in a large cohort of PD patients with long-term follow-up after STN-DBS. Methods: Motor and cognitive disabilities were assessed before, and 1, 2, 5 and 10 years after STN-DBS in 143 consecutive PD patients. We measured motor symptoms Off and On levodopa and STN-DBS, and recorded causes of death. We used linear mixed-models to characterize symptom progression, including interactions between treatment conditions and time to determine how treatments changed efficacy. We used joint models to link progression to mortality. Results: Median observation time was 12 years after surgery, during which akinesia, rigidity and axial symptoms worsened, with mean increases of 8.8 (SD 6.5), 1.8 (3.1) and 5.4 (4.1) points from year 1 to 10 after surgery (On dopamine/On STN-DBS), respectively. Responses to dopaminergic medication and STN-DBS were attenuated with time, but remained effective for all except axial symptoms, for which both treatments and their combination were predicted to be ineffective 20 years after surgery. Cognitive status significantly declined. Forty-one patients died with a median time to death of 9 years after surgery. The current level of axial disability was the only symptom that significantly predicted death (HR=4.30 [SE 1.50] per unit of square-root transformed axial score). Conclusions: We quantified long-term symptom progression and attenuation of dopaminergic medication and STN-DBS treatment efficacy in PD patients, and linked symptom progression to mortality. Axial disability significantly predicts individual risk of death after surgery, which may be useful for planning therapeutic strategies in PD.
Data from: Progressive parkinsonism in older adults is related to the burden of mixed-brain pathologies
Objective: To examine if indices of Parkinson's disease (PD) pathology and other brain pathologies are associated with the progression of parkinsonism in older adults. Methods: We used data from decedents who had undergone annual clinical testing prior to death and structured brain autopsy. Parkinsonism was based on assessment with a modified United Parkinson's Disease Rating Scale and a clinical diagnosis of PD was based on medical history. We employed a series of mixed-effects models controlling for age and sex, to investigate the association of PD pathology (nigral neuronal loss and Lewy bodies) and indices of eight other brain pathologies with the progression of parkinsonism prior to death. Results: During an average of 8.5 years follow-up, more than half (771/1430, 53.9%) developed parkinsonism proximate to death. On average, parkinsonism was progressive (Estimate, 0.130, S.E., 0.005, p<0.001) in all older adults, but more rapid in adults with a clinical diagnosis of PD [N=52; 3.6%] (Estimate, 0.066 S.E., 0.021, p<0.001). Progression of parkinsonism was more rapid in adults with PD pathology (Estimate, 0.087, S.E., 0.013, p<0.001) Alzheimer's disease (AD), and several cerebrovascular pathologies were all independently associated with more rapid progression (all p-Values <0.05). The association between a higher person-specific weighted pathology score and more rapidly progressive parkinsonism did not differ between individual's with and without a clinical diagnosis of PD (Estimate 0.003, S.E., 0.047, p=0.957). Conclusion: The rate of progressive parkinsonism in older adults with and without a clinical diagnosis of PD is related to the burden of mixed-brain pathologies.
Data from: Substantia nigra integrity correlates with sequential working memory in Parkinson's disease
<p>Maintaining and manipulating sequential information online is essential for daily activities such as planning. In Parkinson's disease (PD), deficits in sequential working memory have been associated with altered regional activation and functional connectivity within the basal ganglia. This study demonstrated that the substantia nigra (SN) integrity correlates with basal ganglia dysfunction during sequential working memory. We included 29 patients with PD and 29 healthy controls (HC). We assessed the SN integrity using neuromelanin-sensitive MRI and sequential working memory using functional MRI and a digit ordering task. In this task, participants either recalled a sequence of digits in the original order ('pure recall') or rearranged the digits in ascending order and recalled the new sequence ('reorder & recall'). PD showed smaller SN areas than HC, especially on the left side. Compared to HC, PD showed lower task accuracy, hyper-activation of the subthalamic nucleus, hypo-activation of the caudate nucleus and globus pallidus, and weakened functional connectivity between the bilateral SN and all three basal ganglia regions. Moreover, PD showed distinct brain-behavior and structure-function relationships. Ordering-related accuracy cost ('reorder & recall' <i>versus</i> 'pure recall') correlated with the ordering-related subthalamic activation in HC, but with the ordering-related caudate activation in PD. In PD, the caudate activation correlated with the total SN area, whereas the subthalamic activation correlated with daily exposure to D2/3 receptor agonists. In conclusion, damage to the SN may lead to basal ganglia dysfunction sequential working memory deficits even in early PD.</p>
Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures--Gene Validation FCS
<p>FCS files corresponding to the gene validation experiment described in "Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures"</p> <p>Funding provided in part by the Aligning Science Across Parkinson’s ASAP-000375</p>
Parkinson-CBD
<p>The database includes the raw data of the article “Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson’s Disease” (doi.org/10.3390/ijms22168920). The aim of this study was to evaluate the effects of chronic treatment with cannabidiol (CBD) on Parkinson’s disease-associated neurodegenerative and neuroinflammatory processes, and motor deficits in the 6-hydroxydopamine (6-OHDA) model. Moreover, the potential mechanisms by which CBD exerted its effects in this model has been investigated. The database contains the data obtained by the following evaluations: a) immunohistochemical analysis of the extent of nigrostriatal lesion, b) motor performance assessment by cylinder test (at baseline and after 28days), apomorphine-induced rotation test and rotarod test, c) immunohistochemical analysis of neuroinflammatory response - involving microglia and astrocytes - in the substantia nigra pars compacta, investigating both cell activation and polarization, d)co-localization analysis of transient receptor potential cation channel subfamily V member 1 (TRPV1) and ciliary neurotrophic factor (CNTF) expression in astrocytes.</p> <p>CBD-treated animals showed a reduction of nigrostriatal degeneration accompanied by a damping of the neuroinflammatory response and an improvement of motor performance. In particular, CBD exhibited a preferential action on astrocytes, by activating TRPV1 and enhancing the endogenous neuroprotective response of CNTF. These results overall support the potential therapeutic utility of CBD in PD, as both neuroprotective and symptomatic agent.</p>
A Case-Controlled Pilot Study on Rhythmic Auditory Stimulation-Assisted Gait Training and Conventional Physiotherapy in Patients With Parkinson's Disease Submitted to Deep Brain Stimulation
<p>Deep brain stimulation (DBS) is indicated when motor disturbances in patients with idiopathic Parkinson's disease (PD) are refractory to current treatment options and significantly impair quality of life. However, post-DBS rehabilitation is essential, with particular regard to gait. Rhythmic auditory stimulation (RAS)-assisted treadmill gait rehabilitation within conventional physiotherapy program plays a major role in gait recovery. We explored the effects of a monthly RAS-assisted treadmill training within a conventional physiotherapy program on gait performance and gait-related EEG dynamics (while walking on the RAS-aided treadmill) in PD patients with (<em>n</em> = 10) and without DBS (<em>n</em> = 10). Patients with DBS achieved superior results than those without DBS concerning gait velocity, overall motor performance, and the timed velocity and self-confidence in balance, sit-to-stand (and vice versa) and walking, whereas both groups improved in dynamic and static balance, overall cognitive performance, and the fear of falling. The difference in motor outcomes between the two groups was paralleled by a stronger remodulation of gait cycle-related beta oscillations in patients with DBS as compared to those without DBS. Our work suggests that RAS-assisted gait training plus conventional physiotherapy is a useful strategy to improve gait performance in PD patients with and without DBS. Interestingly, patients with DBS may benefit more from this approach owing to a more focused and dynamic re-configuration of sensorimotor network beta oscillations related to gait secondary to the association between RAS-treadmill, conventional physiotherapy, and DBS. Actually, the coupling of these approaches may help restoring a residually altered beta-band response profile despite DBS intervention, thus better tailoring the gait rehabilitation of these PD patients.</p>
DOPA pheomelanin is increased in nigral neuromelanin of Parkinson's disease
<p>Raw data sets for the manuscript "<strong>DOPA pheomelanin is increased in nigral neuromelanin of Parkinson’s disease"</strong></p>
Apathy and impulsiveness in Parkinson's disease: Two faces of the same coin?
<p>Apathy and impulsiveness are 2 common non-motor symptoms in Parkinson disease that could occur in different periods or simultaneously. Apathy and impulsiveness could be interpreted as opposite extremes of a spectrum of motivated behavior dependent on dopaminergic dysfunction, in which, impulsivity, is a result of a hyperdopaminergic state, whereas apathy is viewed as a hypodopaminergic. The study aimed to investigate the presence of impulsiveness and other neuropsychiatric symptoms in Parkinson disease patients with apathy symptoms. Eighty-one patients with Parkinson disease were enrolled in this retrospective study. All subjects were evaluated by the Italian version of the Dimensional Apathy Scale and the Barratt Impulsiveness Scale-version 11, to assess, respectively, apathy and impulsiveness; they were divided into 2 groups (apathy and no apathy). All patients were administered also with questionnaires assessing depressive and anxious symptoms. Statistical analyses showed relevant results. In no-apathy group, education was a significant predictor on impulsiveness (attentional and motor) and apathy (executive and emotional); depression was a significant predictor on planning impulsivity and apathy. This study aimed to consider the importance of apathy and impulsivity in Parkinson disease. Although these are considered as opposite extremes of a spectrum of motivated behavior dependent on dopaminergic dysfunction, these can also occur separately. Moreover, several variables could represent important predictors of apathy and impulsiveness, such as depression. Future investigations should deepen the role of other demographics and psychological variables.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.