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1,235 results for “pulmonary hypertension”
Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life
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Raw data for the article: MicroRNA-30d and -483-3p for bi-ventricular remodelling and miR-126-3p for pulmonary hypertension in advanced heart failure
<p><strong>Aims: </strong>MicroRNAs play a role in pathogenic mechanisms leading to heart failure. We measured a panel of 754 miRNAs in the myocardial tissue and in the serum of patients with heart failure with reduced ejection fraction due to dilatative idiopathic cardiomyopathy (DCM, N = 10) or ischaemic cardiomyopathy (N = 3), referred to left ventricular assist device implant. We aim to identify circulating miRNAs with high tissue co-expression, significantly associated to echocardiographic and haemodynamic measures.</p> <p><strong>Methods and results: </strong>We have measured a panel of 754 miRNAs in the myocardial tissue [left ventricular (LV) apex] and in the serum obtained at the same time in a well selected study population of end-stage heart failure with reduced ejection fraction due to either DCM or ischaemic cardiomyopathy, referred to continuous flow left ventricular assist device implant. We observed moderate agreement for miR-30d, miR-126-3p, and miR-483-3p. MiR-30d was correlated to LV systolic as well as diastolic volumes (r = 0.78, P = 0.001 and r = 0.80, P = 0.005, respectively), while miR-126-3p was associated to mPAP and PCWP (r = -0.79, P = 0.007 and r = -0.80, P = 0.005, respectively). Finally, serum miR-483-3p had an association with right ventricular end diastolic diameter (r = -0.73, P = 0.02) and central venous pressure (CVP) (r - 0.68 p 0.03).</p> <p><strong>Conclusions: </strong>In patients with DCM, few miRNAs are co-expressed in serum and tissue: They are related to LV remodelling (miR-30d), post-capillary pulmonary artery pressure (miR-126-3p), and right ventricular remodelling/filling pressures (miR-483-3p). Further studies are needed to confirm their role in diagnosis, prognosis or as therapeutic targets in heart failure with reduced ejection fraction.</p>
The added value of right ventricular function normalized for afterload to improve risk stratification of patients with pulmonary arterial hypertension
<p>Dataset of the paper</p>
Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial
ClinicalTrials.gov study NCT03638908. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Is the Two-minute Step Test an Alternative to the Six-minute Walk Test in Pulmonary Hypertension?
ClinicalTrials.gov study NCT07193173. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1)
ClinicalTrials.gov study NCT00617305. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Open-Label Extension of BPS-MR-PAH-201 in Pulmonary Arterial Hypertension (PAH) Patients
ClinicalTrials.gov study NCT00792571. IPD Sharing: Not stated. Countries: 3. Publications: 0.
Effectiveness and Tolerance of Respiratory Rehabilitation in Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT07202793. IPD Sharing: NO. Countries: 1. Publications: 0.
Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension
ClinicalTrials.gov study NCT00313222. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Treprostinil Combined With Tadalafil for Pulmonary Hypertension
ClinicalTrials.gov study NCT01302444. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Carnitine Consumption and Augmentation in Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT04908397. IPD Sharing: YES. Countries: 1. Publications: 0.
Endovenous Sildenafil Early Management in Newborns Pulmonary Hypertension
ClinicalTrials.gov study NCT04912726. IPD Sharing: Not stated. Countries: 0. Publications: 8.
Connective Tissue Disease Patients With Pulmonary Hypertension
ClinicalTrials.gov study NCT05980728. IPD Sharing: NO. Countries: 0. Publications: 3.
An Open-Label Extension Trial of UT-15C Sustained-release (SR) in Subjects With Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT01027949. IPD Sharing: NO. Countries: 20. Publications: 0.
Long-term Safety and Efficacy of Ralinepag in Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT02279745. IPD Sharing: Not stated. Countries: 10. Publications: 0.
Evaluate The Clinical Effectiveness, Safety And Tolerability Of Sildenafil Used In Doses ≥20mg TID For The Treatment Of Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT01365585. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH)
ClinicalTrials.gov study NCT00310830. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction
ClinicalTrials.gov study NCT02070991. IPD Sharing: Not stated. Countries: 11. Publications: 0.
The Role of Endothelin in Pulmonary Hypertension
ClinicalTrials.gov study NCT00759408. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)
ClinicalTrials.gov study NCT01824290. IPD Sharing: YES. Countries: 14. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.