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108
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ShareScore release 0.7.1
Dataset results
108 results for “ACE2”
Apelin; ACE2 and Biomarkers of Alveolar-capillary Permeability in SARS-cov-2 (COVID-19).
ClinicalTrials.gov study NCT04632732. IPD Sharing: NO. Countries: 1. Publications: 49.
Specific Molecular Imaging of DX600 Labeled by PET Radionuclide Targeting ACE2 in Patients
ClinicalTrials.gov study NCT04422457. IPD Sharing: NO. Countries: 1. Publications: 1.
ACE2 Chewing Gum on SARS-CoV-2 Viral Load (COVID 19)
ClinicalTrials.gov study NCT05433181. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effect of RAAS Blockers on ACE2 Levels
ClinicalTrials.gov study NCT05418361. IPD Sharing: Not stated. Countries: 1. Publications: 1.
0 ns and 75 ns configurations of glycosylated ACE2-FC and its interaction with SARS-CoV-2 binding domains
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Raw data for Association of ACE2 gene functional variants with gestational diabetes mellitus risk in a southern Chinese population
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Supplementary Structural Models (SARS-CoV-2 Spike-RBD:ACE2 complex and TMPRSS2) - SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
<p>Structural Models (PDB) of SARS-CoV-2 Spike RBD bound to ACE2 receptors of 215 animals.</p> <p>Structural model of Human TMPRSS2.</p> <p>Modelled using the FunMod pipeline and referenced in the preprint</p> <p><a href="https://www.biorxiv.org/content/10.1101/2020.05.01.072371v5">SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals</a></p> <p> </p>
SARS-CoV-2 spike binding to ACE2-B0AT1 complex
<p>Cryo-EM maps and models of SARS-CoV-2 spike (EMD:21457) and ACE2-B0AT1 (EMD:30039) are illustrated. Membranes are shown around the B0AT1 and approximated around the spike, which is lacking the trans-membrane domain. The binding of the spike to the ACE2 receptor is shown based on the model RBD built into the ACE2-B0AT1 map. The appears to attain a sharp angle wrt. the membrane surface to allow this binding.</p>
3D model of the human ACE2 receptor bound to the SARS-CoV-2 Spike RBD
<p>3D structure model of the receptor-binding domain of SARS-CoV-2 (top) bound to the human ACE2 receptor (bottom). The two highlighted aminoacids - ACE2 D30 (red) and RBD K417 (blue) - are part of a set of interactions that is conserved in animal species susceptible to infection by the virus but are absent from immune species.</p>
Exploring Conformational Landscapes and Binding Mechanisms of Convergent Evolition for the SARS-CoV-2 Spike Omicron Variant Complexes with the ACE2 Receptor Using AlphaFold2-Based Structural Ensembles and Molecular Dynamics Simulations
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AlphaFold2 Modeling and Molecular Dynamics Simulations of the Conformational Ensembles for the SARS-CoV-2 Spike Omicron JN.1, KP.2 and KP.3 Variants : Mutational Profiling of Binding Energetics Reveals Epistatic Drivers of the ACE2 Affinity and Escape Hotspots of Antibody Resistance
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Machine Learning on the Impacts of Mutations in the SARS-CoV-2 Spike RBD on Binding Affinity to Human ACE2 based on Deep Mutational Scanning Data
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Enzyme inhibitors employ different mechanisms to stabilize broad-spectrum antiviral ACE2-Fc fusion proteins
<p>Drugs effective for all variants of a virus are urgently needed to fight current and future pandemics. This can be achieved by creating fusion proteins between the extracellular domains of the virus docking sites on human cells and the Fc part from a human immunoglobulin. The angiotensin-converting enzyme 2 (ACE2) is a viral receptor used by sarbeco betacorona-viruses to infect cells. Fusion proteins comprising extracellular ACE2 domains exhibit high virus neutralization efficiency, but the structure and stability of these molecules are poorly understood. Here we analyzed the structure and stability of an ACE2-IgG4-Fc. We show that the hinge between the ACE2 region and the IgG4-FC is highly flexible, and the conformational dynamics of the fusion protein is restricted by the ACE2 domain[MS1] . Interestingly, chemical compounds inhibiting the enzymatic activity of ACE2 such as DX600 and MLN4760 employ different binding mechanisms to increase the thermal stability of the ACE2 by 8.8 and 14.3 °C, respectively. In particular, MLN4760 induced allosteric effects in the ACE2 domain consistent with structural rearrangements observed in the inhibitor-bound crystal structure. Thus, our findings reveal a general concept for stabilizing the labile receptor segment of therapeutic antiviral fusion proteins[MS2] .</p>
Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype
GEO Series GSE158752. Homo sapiens. 67 samples. Type: Expression profiling by high throughput sequencing.
USP2 inhibition prevents infection with ACE2- dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice
GEO Series GSE237741. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Inducible CD147 up-regulation boosts persistent SARS-CoV-2 infection triggering severe COVID-19 independent of ACE2 [Spatial Transcriptomics]
GEO Series GSE298098. Macaca mulatta; Mus musculus. 24 samples. Type: Other.
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
GEO Series GSE198864. Homo sapiens. 91 samples. Type: Expression profiling by high throughput sequencing.
In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting
GEO Series GSE233642. unidentified; Mesocricetus auratus. 49 samples. Type: Expression profiling by high throughput sequencing.
Targeting Transcriptional Regulation of SARS-CoV-2 Entry Factors ACE2 and TMPRSS2
GEO Series GSE159576. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Lung expression of human ACE2 sensitizes the mouse to SARS-CoV2 infection
GEO Series GSE158069. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.