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254 results for “Abdominal aortic aneurysm”
Differences in local immune cell landscape between Q fever and atherosclerotic abdominal aortic aneurysms identified by multiplex immunohistochemistry
<p><strong>Background:</strong> Chronic Q fever is a zoonosis caused by the bacterium <em>Coxiella burnetii</em> which can manifest as infection of an abdominal aortic aneurysm (AAA). Antibiotic therapy often fails, resulting in severe morbidity and high mortality. Whereas previous studies have focused on inflammatory processes in blood, the aim of this study was to investigate local inflammation in aortic tissue.</p> <p><strong>Methods:</strong> Multiplex immunohistochemistry was used to investigate local inflammation in Q fever AAAs compared to atherosclerotic AAAs in aorta tissue specimen. Two six-plex panels were used to study both the innate and adaptive immune system.</p> <p><strong>Results: </strong>Q fever AAAs and atherosclerotic AAAs contained similar numbers of CD68<sup>+</sup> macrophages and CD3<sup>+</sup> T cells. However, in Q fever AAAs the number of CD68<sup>+</sup>CD206<sup>+</sup> M2 macrophages was increased, while expression of GM-CSF was decreased compared to atherosclerotic AAAs. Furthermore, Q fever AAAs showed an increase in both the number of CD8<sup>+</sup> cytotoxic T cells and CD3<sup>+</sup>CD8<sup>-</sup>FoxP3<sup>+</sup> regulatory T cells. Lastly, Q fever AAAs did not contain any well-defined granulomas.</p> <p><strong>Conclusions:</strong> These findings demonstrate that despite the presence of pro-inflammatory effector cells, persistent local infection with <em>C. burnetii</em> is associated with an immune suppressed micro environment.</p> <p><strong>Funding:</strong> This work was supported by SCAN consortium: European Research Area - CardioVascualar Diseases (ERA-CVD) grant [JTC2017-044] and TTW-NWO open technology grant [STW-14716].</p>
Prediction of Abdominal Aortic Aneurysm Shrinkage After Stent-placement With Artificial Intelligence
ClinicalTrials.gov study NCT06250998. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Follow-up After Endovascular Repair of Abdominal Aortic Aneurysm
ClinicalTrials.gov study NCT00488943. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Exercise Therapy to Treat Adults With Abdominal Aortic Aneurysms
ClinicalTrials.gov study NCT00349947. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Screening for Abdominal Aortic Aneurysm and Popliteal Artery Aneurysm
ClinicalTrials.gov study NCT05360108. IPD Sharing: Not stated. Countries: 2. Publications: 6.
ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair.
ClinicalTrials.gov study NCT04061798. IPD Sharing: YES. Countries: 2. Publications: 33.
Clinical Study on the Prevention of Surgical Wound Complications for Aneurysmal Thoracic-abdominal Aortic Pathology Using the "PREVENA" System
ClinicalTrials.gov study NCT03512470. IPD Sharing: NO. Countries: 1. Publications: 3.
Endovascular Aortic Repair of Free and Contained Ruptured Thoraco-Abdominal Aortic Aneurysm
ClinicalTrials.gov study NCT05956873. IPD Sharing: UNDECIDED. Countries: 1. Publications: 8.
Clinical Study of the Treovance Stent-Graft for Patients With Abdominal Aortic Aneurysms
ClinicalTrials.gov study NCT02009644. IPD Sharing: NO. Countries: 1. Publications: 0.
The PREHAAAB Trial: Multimodal Prehabilitation for Patients Awaiting Open Abdominal Aortic Aneurysm Repair
ClinicalTrials.gov study NCT05756283. IPD Sharing: NO. Countries: 1. Publications: 6.
Abdominal Compartment Syndrome and Ruptured Aortic Aneurysm : Validation of a Predictive Test
ClinicalTrials.gov study NCT02859662. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Effectiveness of an Off-the-shelf Single REnal Scalloped sTent-graft for HOstile NEck Infrarenal Abdominal Aortic Aneurysm
ClinicalTrials.gov study NCT05609539. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Sodium Fluoride Imaging of Abdominal Aortic Aneurysms
ClinicalTrials.gov study NCT02229006. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair
ClinicalTrials.gov study NCT01225094. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Elective Treatment Rates and Surgical Non-eligibility Among Men and Women With Intact Abdominal Aortic Aneurysms
ClinicalTrials.gov study NCT05346289. IPD Sharing: NO. Countries: 1. Publications: 18.
Computed Tomography Scan Versus Color Duplex Ultrasound for Surveillance of Endovascular Repair of Abdominal Aortic Aneurysm. A Prospective Multicenter Study
ClinicalTrials.gov study NCT01230203. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery
ClinicalTrials.gov study NCT02292667. IPD Sharing: NO. Countries: 1. Publications: 1.
Preventing Myocardial Ischemia by Preconditioning in Elective Operation for Abdominal Aortic Aneurysm
ClinicalTrials.gov study NCT01523262. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Modern Technology For Learning and Psychosocial Support In Patients With Abdominal Aortic Aneurysm
ClinicalTrials.gov study NCT03157973. IPD Sharing: NO. Countries: 1. Publications: 2.
The Efficacy of Ticagrelor on Abdominal Aortic Aneurysm (AAA) Expansion
ClinicalTrials.gov study NCT02070653. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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OpenNeuro
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