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2,143 results for “All Spinal Cord”
Contours of the caregiver experience: Social resources and health behaviors in caregiving partners of persons with a spinal cord injury
<p class="MsoCommentText"><b>Background and rationale:</b><b> </b>Informal caregiving is highly prevalent in Switzerland and in the long-term associated with chronic stress as evidenced by its negative effects on caregivers health and well-being. To date, most of research on informal caregiving has been focused on the elderly. Yet, the evidence from these studies may not be applicable and misinform policy in context of physical disabilities, which may further concerns younger-aged caregivers. Spinal cord injury (SCI) is an exemplary condition for the enforced need of long-term informal care that oftentimes occurs in middle-age. To better understand the mechanisms behind the health-adverse effects of caregiving, a improved understanding of the interplay between social and behavioral factors and the caregiver experience is needed. This project was a follow-up of the longitudinal pro-WELL study (pro-WELL 1), which investigated associations of productive activities and social relationships with health and well-being in persons with SCI and their caregiving partners (SNSF Project 100017_153256/1). Using the follow-up funding by SNF (pro-WELL 2) we further explored the pro-WELL data to foster a comprehensive understanding of the caregiver experience, also to promote the discussion and transfer of the gained knowledge to stakeholders.</p> <p><b>Objectives:</b> The overall objective of this pro-WELL follow-up study ("pro-WELL 2") was to explore the relationship of social and behavioral factors with the caregiver experience to better understand the causal pathway linking the caregiver experience with health and well-being of the caregiving partners of persons with SCI. The specific aims were to investigate 1) whether socioeconomic conditions shape the caregiver experience, 2) whether social relationships moderate the association between the caregiver experience and health, and 3) whether the caregiver experience has an effect on health behaviors in the caregiving partners of persons with SCI. Using the evidence gained by pro-WELL 1 and 2, we aimed to conduct stakeholder dialogues in order to develop strategies to support burdened caregivers within the network of the Swiss Paraplegic Group.</p> <p><span><b>Methods: </b>Pro-WELL is an observational longitudinal survey with three measurement waves. Data collection was completed in January 2017 and n=133, n=123, and n=119 couples participated at baseline, month 6 and month 12, respectively. The analyses were based on longitudinal dyadic data from the caregiving partners of persons with SCI that completed at least two waves (n=123). We applied multivariable regression modelling and path analysis to explore the research questions.</span></p> <p><span><b>Results: </b>We demonstrated that caregivers with lower socioeconomic status reported a higher burden of care (Tough, Brinkhof, Siegrist, Fekete 2020, Int J Equity Health), provided evidence that social support moderates the association between the caregiver burden and health (Tough, Brinkhof, Fekete. submitted), and showed that the caregiver burden negatively affects specific health behaviors (Tough, Brinkhof, Fekete 2020, Health Psychology Behav Med)</span><span>. </span></p> <p><span><b>Discussion:</b> This study was among the first to investigate the social and behavioral factors related to the caregiver experience, and to evaluate possible pathways through which the caregiver experience may impact upon health and well-being in middle-aged caregivers of persons with a physical disability. This study identified targets for interventions aimed at improving the caregiver experience with the ultimate goal to contribute to caregivers' health and well-being. The results of the pro-WELL 2 study were used to inform stakeholder dialogues on the current needs and potential actions to improve the situation of informal caregivers in Switzerland. </span></p>
Comparing natural hydrogels to self-assembling peptides in spinal cord injury treatment: a systematic review
<p><strong>Abstract</strong></p> <p><em><strong>Background:</strong></em><em> </em>In many cases, central nervous system (CNS) injury is unchanging due to the absence of neuronal regeneration and repair capabilities.<strong> </strong>In recent years, regenerative medicine, and especially hydrogels, have reached a significant amount of attention for their promising results for the treatment of spinal cord injury (SCI) currently considered permanent. Hydrogels are categorized based on their foundation: synthetic, natural, and combination. The objective of this study was to compare the properties and efficacy of commonly used hydrogels, like collagen, and other natural peptides with synthetic self-assembling peptide hydrogels in the treatment of SCI. </p> <p><em><strong>Methods</strong></em><em>:</em><em> </em>Articles were searched in PubMed, Scopus, Web of Science, and Embase. All studies from 1985 until January 2020 were included in the primary search. Eligible articles were included based on the following criteria: administering hydrogels (both natural and synthetic) for SCI treatment, soley foucsing on spinal cord injury treatment, and published in a peer-reviewd journal. Data surronding xonal regeneration, revascularization, elasticity, drug delivery efficacy, and porosity were extracted.</p> <p><em><strong>Results:</strong></em> A total of 24 articles were included for full-text review and data extraction. There were only one experimental study directly comparing Collagen I (as natural hydorgel) and PEG (as synthetic hydrogels) in an <em>in vitro </em>setting. The included study suggested PEG’s cell behavior is more expectable in the injury site, which makes it a more reliable scaffold.</p> <p><em><strong>Conclusions:</strong></em> There is limited research comparing and evaluating both types of natural and self-assembling peptides (SAPs) in the same animal or <em>in vitro</em> study, despite its importance. Although we assume that the remodeling of natural scaffolds may lead to a stable hydrogel, there was not a definitive conclusion that synthetic hydrogels are more beneficial than natural hydrogels in neuronal regeneration.</p>
Search strategies for domiciliary ventilation of spinal cord injured adults
<p>The dataset includes the complete, reproducible search strategies for all literature databases searched during this project.</p>
Figure 2 in The vertebral column of Chaetophractus villosus (Desmarest, 1804) (Chlamyphoridae, Cingulata, Xenarthra): Anatomy and Thoracolumbar variation. Spinal cord relation
Figure 2. Trajectory of the vertebral artery and associated nerves in C. villosus. (A) Schematic drawing that shows the path of the vertebral artery along the cervical region in dorsal view. (B) Schematic drawing that shows the path of the vertebral artery within the lateral mass of the atlas in posterodorsal view.
Figure 1 in The vertebral column of Chaetophractus villosus (Desmarest, 1804) (Chlamyphoridae, Cingulata, Xenarthra): Anatomy and Thoracolumbar variation. Spinal cord relation
Figure 1. Major details in every region of the axial skeleton of C. villosus. (A-B) Anterior and posterior view of the atlas (C1), respectively. t.a. = transverse apophysis, ax.fc. = articular facet for the axis, ax.ne.fc. = articular facet for the neurapophysis of the axis, f.d. = fovea dentis, g.c. = glenoid cavity for the occipital bones, in lateral mass (l.m.), tb. = tuberosity, t.f. = transverse foramen. (C-D) Lateral and ventral view of the mesocervical bone (C2 + C3 + C4), respectively: od.pr. = odontoid process, ax. = axis, t.a. = transverse apophysis, ne. = neurapophysis. (E) left image: laterodorsal view of the axial region including the mesocervical bone, posterior free cervicals (C5-C7), and first thoracic vertebra (T1); right image: lateroventral view of the last free cervical (C7) and first thoracic vertebrae. ne. = neurapophysis, int.f. = intervertebral foramina, grey areas show the articular facets in C7 and T1 for the first rib. (F-G) dorsal and lateral views of the axial region between T4 and T7, respectively. Black arrowheads indicate the dorsal xenarthrales, me. = metapophysis, an. = anapophysis, tb.fc. = facet for the tubercle of the rib, cp.fc. = facet for the capitulum of the rib. The supplementary articulations (= xenarthrales) are clearly shown in the schematic drawing in the circular areas. (H) anterior (left) and posterior (right) view of T9 showing the pre- and postzygapophyses, respectively. Black arrowheads indicate the vertical component in both articular facets. (I) lateral view of the axial region between the last thoracics (T9-T11) and first lumbar (L1). Grey surfaces in T11 (also outlined in black) and L1 indicate the facets of the ventral xenarthrales. an. = anapophysis, a.dfc. = anterior demifacet for the capitulum of the rib, me. = metapophysis. (J-K) Dorsal and lateral views of the axial skeleton (with the exception of the caudal region) of a specimen that bears 11 thoracic and 3 lumbar vertebrae. ac. = Acetabulum, an. = anapophysis, a.r. = anterior ramus of the pubis, di.vb. = diaphragmatic vertebrae, il. = ilium, il.tb. = iliac tuberosity, is. = ischium, is.tb. = ischial tuberosity, me. = metapophysis, o.f. = obturator foramen, pb. = pubis, p.r. = posterior ramus of the pubis, S. = synsacral vertebrae, s.is.f. = sacroischial foramen, v.r. = ventral ramus of the pubis. * Dorsoventral curvature of the cervical vertebrae.
Figure 4 in The vertebral column of Chaetophractus villosus (Desmarest, 1804) (Chlamyphoridae, Cingulata, Xenarthra): Anatomy and Thoracolumbar variation. Spinal cord relation
Figure 4. Schematic drawing of the anterior face of Cd5 and its relationship with the caudal osteoderms. v.b. = vertebral body.
Figure 3 in The vertebral column of Chaetophractus villosus (Desmarest, 1804) (Chlamyphoridae, Cingulata, Xenarthra): Anatomy and Thoracolumbar variation. Spinal cord relation
Figure 3. Axial skeleton in two specimens of C. villosus that deviate from the thoracolumbar count of 11T + 3L. (A) Specimen with 12T + 3L (LMED-652). Above, dorsal view of the thoracic, lumbar, and sacral regions. Below left, lateral view of the lumbosacral region. Below right, ventral view of the pelvis. Black arrowheads indicate the synsacral foramina, (B) Specimen 12T + 2L (LMED-637). Above, dorsal view of the thoracic, lumbar, and sacral regions. Below left, lateral view of the lumbosacral region. Below right, ventral view of the pelvis articulating with the first free caudal (Cd1). do.rd. = dorsal ridge; rb.fc. = rib facet, pb.sy. = pubic symphysis, v.r. = ventral ramus, t.p. = transverse process in first caudal (Cd1).
Colonic contractility recordings following spinal cord injury in mice with dietary fiber interventions
<p>Here, we performed colonic contractility measurements in mice following spinal cord injury, with or without a dietary fiber intervention at 2 weeks post-injury. Provided here are is a .zip file containing the raw ABF measurement files necessary for analysis of the frequency and amplitude of contractions. <span>Breifly, data were acquired using AxoClamp 900A (Axon Instruments). Each tissue segment was recorded for at least 30min in 5min gap-free files. 15min of stable recordings were selected from the middle of each recording session for analysis. Using Clampfit software (Molecular Devices, RRID:SCR_011323), data files were filtered at 300Hz (Bessel 8-pole) and reduced by a factor of 100. Files were concatenated and the baseline was adjusted based on overall slope. Amplitude was calculated by subtracting the minimum value of the whole trace from the value of the peak being assessed. </span></p>
A novel use of virtual reality in the treatment of cognitive and motor deficit in spinal cord injury
<p>Aim of this study is to evaluate the cognitive and motor outcomes after a combined rehabilitative training using a standard cognitive approach and virtual reality (VR), in a patient with spinal cord injury (SCI). A 60-year-old right-handed man, affected by incomplete cervical SCI, came to our observation for a moderate tetraparesis, mainly involving the left side, after about 6-months from the acute event. The neurological examination showed imbalance with upper limb incoordination, besides the paresis mainly involving the left side. At a neuropsychological evaluation, he presented important impairment in cognitive and behavioural status, with temporal and spatial disorientation, a reduction of attention and memory process, deficit of executive function and a severe depression of mood, which was not detected during the previous recovery. Motor and cognitive deficits in SCI. The patient was 1st submitted to standard cognitive training and traditional physiotherapy, and then to a combined therapeutic approach, in which virtual reality training was provided by means of the virtual reality rehabilitation system (VRRS, Khymeia, Italy). After the combined therapeutic approach with the VRRS training, we observed a significant improvement in different cognitive domains, a notable reduction of anxiety and depressive symptoms, as well as motor performance, and balance improvement. Virtual reality can be considered a promising tool for the rehabilitation of different neurological disorders, including patients with both motor and cognitive deficits following SCI.</p>
Effectiveness of high-frequency cervical spinal cord stimulation in the treatment of refractory trigeminal neuropathy
<p>Treatment of chronic neuropathic pain in the head and face regions presents a challenge for pain specialists due to the lack of reliable medical and surgical approaches. A 62-year-old patient came to our attention for an intense facial pain secondary to a lesion of the right trigeminal nerve (all branches) due to a petroclival meningioma. The patient also presented with gait impairment as well as a deficit of the right facial, auditory, trochlear and abducens cranial nerves. Conventional medical management (CMM) as well as tonic SCS were already adopted but they all dramatically failed. We intervened with the use of high-frequency (10 kHz) spinal cord stimulation (HFSCS) at the cervicomedullary junction (CMJ). The patient was thus provided with HFSCS at the CMJ. Pain and quality of life (QoL) were assessed 1 and 3 months after implantation. We also tested the trigeminal-facial reflex responses. HFSCS led to a full relief from the debilitating electric shocks like pain in the right hemiface, even though a background dull pain appeared. The gradual addition of pregabalin helped in fully relieving the painful symptomatology, with a significant improvement in QoL. Moreover, sensitivity amelioration on the inner portion of the mouth allowed the patient to start feeding again also using that side of the mouth. These findings were paralleled by a significant reshape of trigeminal-facial reflex responses suggesting an inhibition of nociceptive sensory inputs at brainstem level following HFSCS. This is the first report suggesting the usefulness of HFSCS at the CMJ in neuropathic pain due to trigeminal nerve neuropathy non-responsive to tonic SCS and CMM.</p>
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
<p class="MsoNormal"><span><strong>Background:</strong> Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. </span>A neuroprotective compound, ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup>also known as Semax has <span>shown neuroprotective and anti-inflammatory properties. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> <span>also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI.</p> <p><span><strong>Method: </strong>We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup><span>was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. </span>The preparations tissue sample were fixed in formalin and examined for immunohistochemistry<span>. Quantitative measurement of anti-inflammatory cytokine (</span>IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies.</p> <p> </p> <p><strong>Result:</strong> Rats with mild SCI that were given ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group.</p> <p> </p> <p><strong>Conclusion: </strong>Administration of ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.</p>
Feasibility of using remotely delivered Spring Forest Qigong to reduce neuropathic pain in adults with spinal cord injury: A pilot study
<p class="mb15"><strong>Introduction:</strong> Approximately 69% of 299,000 Americans with spinal cord injury (SCI) suffer debilitating chronic neuropathic pain, which is intractable to treatment. The aim of this study is to determine feasibility, as the primary objective, and estimates of efficacy of a remotely delivered Qigong intervention in adults with SCI-related neuropathic pain, as the secondary objective.</p> <p class="mb15"><strong>Methods:</strong> We recruited adults with SCI-related neuropathic pain, with SCI ≥3 months, with complete or incomplete SCI, and highest neuropathic pain level of >3 on the Numeric Pain Rating Scale (NPRS), using nationwide volunteer sampling. Using a non-randomized controlled trial design, participants practiced Spring Forest Qigong's "Five Element Qigong Healing Movements" (online video) by combining movement to the best of their ability with kinesthetic imagery, at least 3x/week for 12 weeks. Adherence was automatically tracked through the Spring Forest Qigong website. Outcomes of neuropathic pain intensity (NPRS) were assessed weekly, and SCI-related symptoms were assessed at baseline, 6, and 12 weeks of Qigong practice and at 6-week and 1-year follow-ups.</p> <p class="mb15"><strong>Results:</strong> We recruited 23 adults with chronic SCI (7/2021–2/2023). In total, 18 participants started the study and completed all study components, including the 6-week follow-up. Twelve participants completed the 1-year follow-up assessment. Feasibility was demonstrated through participants' willingness to participate, adherence, and acceptability of the study. Mean age of the 18 participants was 60 ± 12 years, and they were 15 ± 11 years post-SCI with the highest baseline <em>neuropathic pain</em> of 7.94 ± 2.33, which was reduced to 4.17 ± 3.07 after 12 weeks of Qigong practice (Cohen's <em>d</em> = 1.75). This pain relief remained at 6-week and 1-year follow-ups. Participants reported reduced spasm frequency (change score 1.17 ± 1.20, <em>d</em> = 0.98) and severity (0.72 ± 1.02, <em>d</em> = 0.71), reduced interference of neuropathic pain on mood (3.44 ± 2.53, <em>d</em> = 1.36), sleep (3.39 ± 2.40, <em>d</em> = 1.41), daily activities (3.17 ± 2.77, <em>d</em> = 1.14), greater ability to perform functional activities (6.68 ± 3.07, <em>d</em> = 2.18), and improved mood (2.33 ± 3.31, <em>d</em> = 0.70) after Qigong.</p> <p class="mb15"><strong>Discussion:</strong> Remote Spring Forest Qigong's "Five Element Qigong Healing Movements" practice is feasible in adults with SCI-related neuropathic pain, with promising prolonged results of neuropathic pain relief and improvement in SCI-related symptoms after Qigong practice.</p> <p class="mb15"><strong>Clinical trial registration:</strong> <a href="https://www.clinicaltrials.gov/ct2/show/NCT04917107">https://www.clinicaltrials.gov/ct2/show/NCT04917107</a>, identifier NCT04917107</p>
A database of the healthy human spinal cord morphometry in the PAM50 template space
<p><strong>About: </strong>This dataset is a collection of tabular files containing normative values of normalized metrics of human spinal cord MRI morphological measurements (cross-sectional area, AP diameter, transverse diameter, compression ratio, eccentricity, and solidity) of 105 male and 98 female participants. Aggregated metrics (for provenance recording) and demographics are also provided.</p><p>Dataset provided for NeuroLibre preprint. Author repo: https://github.com/valosekj/PAM50-normalized-metrics-paper NeuroLibre fork:https://github.com/roboneurolibre/PAM50-normalized-metrics-paper</p><p>For details, please visit the corresponding <a href="https://github.com/neurolibre/neurolibre-reviews/issues/17">NeuroLibre technical screening.</a></p><p><a href="https://neurolibre.org"><strong>https://neurolibre.org</strong></a></p>
Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury
ClinicalTrials.gov study NCT03302793. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury
ClinicalTrials.gov study NCT00833105. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury
ClinicalTrials.gov study NCT03083366. IPD Sharing: NO. Countries: 1. Publications: 1.
Spinal Cord Injury Vocational Integration Program (SCI-VIP)
ClinicalTrials.gov study NCT00117806. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury
ClinicalTrials.gov study NCT02878850. IPD Sharing: NO. Countries: 1. Publications: 2.
Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation
ClinicalTrials.gov study NCT03458871. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Reducing Anticholinergic Bladder Medication Use in Spinal Cord Injury With Home Neuromodulation
ClinicalTrials.gov study NCT04074616. IPD Sharing: NO. Countries: 1. Publications: 27.
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