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Dataset results
75 results for “Antiretroviral Drugs”
Effect of Medication Diaries on Adherence to Highly Active Antiretroviral Drugs Among HIV-1 Infected Kenyan Children
ClinicalTrials.gov study NCT00194545. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Trial of Anti-CD4 Antibody UB-421 in Combination With Optimized Background Antiretroviral Therapy in Patients With Multi-Drug Resistant HIV-1 Infection
ClinicalTrials.gov study NCT05582694. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Antiretroviral Drug Interaction Study in Volunteers With HIV
ClinicalTrials.gov study NCT01479361. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Directly Observed Antiretroviral Therapy Among Active Drug Users
ClinicalTrials.gov study NCT00367172. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study to Evaluate the Effects of Genetic Factors on the Pharmacokinetics of Antiretroviral Drugs During Pregnancy and Lactation
ClinicalTrials.gov study NCT02269462. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients
ClinicalTrials.gov study NCT00421473. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant People.
ClinicalTrials.gov study NCT00404989. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Regimens in HIV Infected Patients Who Have Never Been Exposed to Highly Active Antiretroviral Therapy (HAART)
ClinicalTrials.gov study NCT00000922. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Optimal Dosing of 1st Line Antituberculosis and Antiretroviral Drugs in Children (a Pharmacokinetic Study)
ClinicalTrials.gov study NCT01637558. IPD Sharing: UNDECIDED. Countries: 2. Publications: 3.
Drug-drug Interactions Between Antiretroviral Drugs and Cardiovascular Drugs in Elderly Patients
ClinicalTrials.gov study NCT03515772. IPD Sharing: YES. Countries: 1. Publications: 1.
HIV Antiretroviral Drugs and Metabolism
ClinicalTrials.gov study NCT00525239. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Assessment of Drug-drug Interactions Between Masculinizing Hormone Therapy and Antiretroviral Agents Concomitantly for Pre-exposure Prophylaxis Among Transgender Men
ClinicalTrials.gov study NCT04593680. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of an Investigational Drug in Human Immunodeficiency Virus (HIV)-Infected Patients Failing Current Antiretroviral Therapies (0518-005)(COMPLETED)
ClinicalTrials.gov study NCT00105157. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Controlling Acute or Early HIV Infection With Antiretroviral Drugs, Without a Candidate Vaccine.As Reported Previously, the Candidate Vaccie Was Not Provided by the Maufacturer as Promised
ClinicalTrials.gov study NCT00238459. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Development of a Urine-Based Point-of-Care Test for Adherence to Antiretroviral Drugs
ClinicalTrials.gov study NCT04302896. IPD Sharing: NO. Countries: 1. Publications: 1.
A Phase 1 Antiretroviral Drug-Drug Interaction Study in Healthy Volunteers (DDI)
ClinicalTrials.gov study NCT02277600. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Assess the Efficacy of Raltegravir (Isentress®), Administered in Combination With Other Antiretroviral Drugs as Treatment for Adults and Older Adults Infected With the Human Immunodeficienc
ClinicalTrials.gov study NCT01213316. IPD Sharing: Not stated. Countries: 0. Publications: 5.
Data from: Early antiretroviral therapy and potent second-line drugs could decrease HIV incidence of drug resistance
Early initiation of antiretroviral therapy (ART) reduces the risk of drug-sensitive HIV transmission but may increase the transmission of drug-resistant HIV. We used a mathematical model to estimate the long-term population-level benefits of ART and determine the scenarios under which earlier ART (treatment at 1 year post-infection, on average) could decrease simultaneously both total and drug-resistant HIV incidence (new infections). We constructed an infection-age-structured mathematical model that tracked the transmission rates over the course of infection and modelled the patients' life expectancy as a function of ART initiation timing. We fitted this model to the annual AIDS incidence and death data directly, and to resistance data and demographic data indirectly among men who have sex with men (MSM) in San Francisco. Using counterfactual scenarios, we assessed the impact on total and drug-resistant HIV incidence of ART initiation timing, frequency of acquired drug resistance, and second-line drug effectiveness (defined as the combination of resistance monitoring, biomedical drug efficacy and adherence). Earlier ART initiation could decrease the number of both total and drug-resistant HIV incidence when second-line drug effectiveness is sufficiently high (greater than 80%), but increase the proportion of new infections that are drug resistant. Thus, resistance may paradoxically appear to be increasing while actually decreasing.
Modulation of Multidrug Resistance Protein 1-mediated transport processes by the antiretroviral drug ritonavir
<p>We here provide the structure files, trajectories and topology files for analyzing and reproducing simulations performed in the publication: "<strong>Modulation of Multidrug Resistance Protein 1-mediated transport processes by the antiretroviral drug ritonavir</strong>".</p> <p>Classical molecular dynamics simulation of rat Mrp1 have been performed in complex with native substrates like GSH and GSSG or drug molecules like ritonavir, to study binding modes of different combinations. </p> <p>Structure and trajectory files (all 1 µs long) as well as recorded movies of the time progression are provided for the following simulation systems:</p> <p>1. GSH bound to rat Mrp1</p> <p>2. GSSG bound to rat Mrp1</p> <p>3. Ritonavir bound to rat Mrp1</p> <p>4. GSH + Ritonavir bound to rat Mrp1</p> <p>5. GSSG + Ritonavir bound to rat Mrp1</p> <p>Additionally itp files (GROMACS format) containing parameter information about the ligands GSH, GSSG and Ritonavir are provided for the force field CHARMM36m. </p> <p>Raw data of the homology modeling of rat Mrp1 by I-Tasser as well as Docking results produced via AutoDock4 are uploaded as zip directories. </p> <p> </p>
The Lymphoid Tissue Pharmacology of Antiretroviral Drugs
ClinicalTrials.gov study NCT02707926. IPD Sharing: YES. Countries: 0. Publications: 2.
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