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29,145 results for “Association”
Genome-wide association summary statistics for back pain
<p>The dataset contains results of a genome-wide association study of back pain. Two files contain association summary statistics for discovery GWAS based on the analysis of 350,000 white British individuals from the UK Biobank and meta-analysis GWAS based on the meta-analysis of the same 350,000 individuals and additional 103,862 individuals of European Ancestry from the UK biobank (total N = 453,862). The phenotype of back pain was defined by the answer provided by the UK biobank participants to the following question: "Pain type(s) experienced in last month". Those who reported “Back pain”, were considered as cases, all the rest were considered as controls. Individuals who did not reply or replied: "Prefer not to answer" or "Pain all over the body" were excluded. This dataset is also available for graphical exploration in the genomic context at <a href="http://gwasarchive.org/">http://gwasarchive.org</a>. </p> <p>The data are provided on an "AS-IS" basis, without warranty of any type, expressed or implied, including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose. If investigators use these data, any and all consequences are entirely their responsibility. By downloading and using these data, you agree that you will cite the appropriate publication in any communications or publications arising directly or indirectly from these data; for utilisation of data available prior to publication, you agree to respect the requested responsibilities of resource users under 2003 Fort Lauderdale principles; you agree that you will never attempt to identify any participant. This research has been conducted using the UK Biobank Resource and the use of the data is guided by the principles formulated by the UK Biobank.</p> <p><strong>When using downloaded data, please cite corresponding paper and this repository:</strong></p> <ol> <li>Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals. Freidin, Maxim; Tsepilov, Yakov; Palmer, Melody; Karssen, Lennart; Suri, Pradeep; Aulchenko, Yurii; Williams, Frances MK,# CHARGE Musculoskeletal Working Group. PAIN: February 06, 2019 - Volume Articles in Press - Issue - p<br> doi: 10.1097/j.pain.0000000000001514</li> <li>Maxim B Freidin, Yakov A Tsepilov, Melody Palmer, Lennart Karssen, CHARGE Musculoskeletal Working Group, Pradeep Suri, … Frances MK Williams. (2018). Genome-wide association summary statistics for back pain (Version 1) [Data set]. Zenodo. http://doi.org/10.5281/zenodo.1319332</li> </ol> <p><strong>Funding:</strong></p> <p>This study was supported by the European Community’s Seventh Framework Programme funded project PainOmics (Grant agreement # 602736). <br> The research has been conducted using the UK Biobank Resource (project # 18219).</p> <p>The development of software implementing SMR/HEIDI test and database for GWAS results was supported by the Russian Ministry of Science and Education under the 5-100 Excellence Program”.</p> <p>Dr. Suri’s time for this work was supported by VA Career Development Award # 1IK2RX001515 from the United States (U.S.) Department of Veterans Affairs Rehabilitation Research and Development Service. The contents of this work do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.</p> <p>Dr. Tsepilov’s time for this work was supported in part by the Russian Ministry of Science and Education under the 5-100 Excellence Program.</p> <p><strong>Column headers - discovery (350K)</strong></p> <ol> <li>CHR: chromosome</li> <li>POS: position (GRCh37 build) </li> <li>ID: SNP rsID</li> <li>REF: reference allele (coded as "0")</li> <li>ALT: effect allele (coded as "1")</li> <li>CASE_ALLELE_CT: allele observation count in cases</li> <li>CTRL_ALLELE_CT: allele observation count in controls</li> <li>ALT_FREQ: effect allele frequency </li> <li>MACH_R2: imputation quality</li> <li>TEST: model of association test (additive)</li> <li>OBS_CT: sample size</li> <li>BETA: effect size of effect allele</li> <li>SE: standard error of effect size</li> <li>T_STAT: Z-value of effect allele</li> <li>P: P-value of association (without GC correction)</li> <li>MAF: minor allele frequency</li> </ol> <p><strong>Column headers - meta-analysis (450K)</strong></p> <ol> <li>MarkerName: SNP rsID</li> <li>Allele1: effect allele (coded as "1")</li> <li>Allele2: reference allele (coded as "0")</li> <li>Freq1: effect allele frequency</li> <li>FreqSE: standard error of effect allele frequency</li> <li>Effect: effect size of effect allele</li> <li>StdErr: standard error of effect size</li> <li>P-value: P-value of association (without GC correction)</li> <li>Direction: sign of effect in discovery and replication samples</li> <li>n_total: Total sample size</li> <li>CHR: chromosome</li> <li>POS: position (GRCh37 build) </li> <li>MACH_R2_discovery: imputation quality in discovery sample</li> </ol>
Data of European University Association (EUA) Open Access Survey 2017-2018
<p>This database refers to the data collected by the European University Association (EUA) for its Open Access Survey 2017-2018, which gathered responses from universities and higher education institutions across Europe. The full report published by the association is available at <a href="https://eua.eu/resources/publications/826:2017-2018-eua-open-access-survey-results.html">https://eua.eu/resources/publications/826:2017-2018-eua-open-access-survey-results.html</a>.</p> <p>The data included in this database refers only to those universities and higher education institutions that accepted their data to be available in open access (n=266). All information that could lead to the identification of individual universities and higher education institutions was removed from the database. The following files are available:</p> <ul> <li>Questionnaire</li> <li>Database in the following formats: .sav (IBM SPSS Statistics), .xlsx (Microsoft Excel) and .csv</li> <li>Codebook: includes information on all the variables and their coding.</li> </ul>
Image data of co-localization of IgG and HEV ORF2 protein in a case of hepatitis E-associated kidney disease
<p><span>Image data for a co-localization study of IgG with HEV ORF2 protein in a </span><span>de novo immune complex-mediated glomerulonephritis (GN) case in</span><span> a kidney transplant recipient </span><span>with chronic hepatitis E (Leblond and Helmchen, et al. 2024).<span> </span>Immunofluorescence images are provided for 25 glomeruli at low magnification (20x, 0.227 micron/pixel) and for 16 glomeruli at high magnification (100x, 0.0454 micron/pixel). For each example glomeruli the green channel represents IgG antibody staining with FITC, and the magenta channel represent anti-HEV ORF2 staining using Alexa Fluor 546.</span></p> <p><span>Methods: </span></p> <p><span>Mouse monoclonal antibody clone 1E6 against the HEV ORF2 protein was incubated for 1h at a dilution of 1:125 followed by a mix of Alexa Fluor 546-conjugated goat anti-mouse antibody (Invitrogen BV, A11018) and FITC-conjugated Rabbit anti-Human IgG (Gamma chain, Diagnostic Biosystem, F008) for 1hat a dilution of 1:50. Following automated staining, the slides were hand -washed in distilled H<sub>2</sub>O. Tissue was covered with Vectashield® Antifade Mounting Medium with DAPI (VectorLaboratories, H-1200), covered with a coverslip and stored at 4°C until evaluation.</span></p> <p><span>Immunofluorescence images were acquired with an upright fluorescence microscope (AxioImager.Z2 controlled by ZEN Blue software; 89 North Photofluor LM-75 light source, and Axiocam 503 mono camera; Zeiss, Jena, Germany), equipped with the following objectives: 20x (NA 0.5, Plan-NEOFLUAR), 40x (NA 1.4 oil, Plan-APOCHROMAT), and 100x (NA 1.45 oil, Plan-APOCHROMAT) objectives. This setup provides an excellent spatial resolution (nominally about 200 nm lateral resolution in our study; pixel size was 45.4 nm for 100x objective). High resolution images were taken with the 100x objective using the ApoTome.2 module with deconvolution (grid 5 lp/mm; section thickness 0.7 µm). We used Vysis Abbott Chroma filter sets (Blue: excitation (ex) 335-383 nm, emission (em) 420-470; green: ex 481-507 nm; em 521-551 nm; red: ex 534-556 nm, em 574- 606 nm). Co-localization of IgG and HEV ORF2 staining was quantified using Fiji software (Schindelin et al., 2012) and the JACoP ImageJ plug-in. </span></p>
Environmental and biological data associated with captive-reared Delta Smelt Study, Sacramento-San Joaquin Delta, CA, January-March 2019
The endangered Delta Smelt Hypomesus transpacificus is an osmerid fish endemic to the upper San Francisco Estuary. A captive breeding program for the species led by the Fish Culture and Conservation Laboratory (FCCL), University of California, Davis, began in 1996 to create a refuge population. In order to better understand how captive Delta Smelt would fare in conditions outside of the hatchery, we placed captive-reared fish in enclosures in the Sacramento San-Joaquin Delta, and evaluated their ability to survive, feed, and maintain condition. Fish were acclimated in the hatchery at FCCL, tagged, swabbed, weighed, measured, and transferred to enclosures in the field. There were three types of enclosures (n=2 for each type), varying in mesh size and wrap condition. In January 2019, 384 adult Delta Smelt (243 days post hatch) were transferred to enclosures in Rio Vista. In February 2019, 360 adult Delta Smelt (278 days post hatch) were transferred to enclosures in the Deepwater Shipping Channel. For each deployment, fish remained in enclosures for approximately one month, then were retrieved from enclosures, euthanized, identified, weighed and measured. A subset were also analyzed for diet contents. During the one-month long deployments, cages were checked for biofouling, damage, and dead fish, and water quality measurements and zooplankton samples were collected.
Ecosystem metabolism and associated environmental data for a forested, meadow and reforested reach of White Clay Creek, Chester Co., Pennsylvania; 1971-1975 and 1997-2010
Ecosystem metabolism data for a 3rd-order Piedmont stream were collected during two periods: P1- April 1971 – Dec 1975, and P2- May 1997 – January 2010. Measures were made in a meadow and a forested reach during each period and in a reforested (formerly meadow) reach during the latter years of P2. During P1, measures were made by transferring streambed substrata to chambers in water jackets located on the streambank and measuring dissolved oxygen changes over diel periods. During P2, open system measures of dissolved O2 change were made for several days in warm and cold seasons, with reaeration determined from a propane injection experiment. Metabolism estimates were determined from diel curves of dissolved O2 change. Photosynthetically active radiation (PAR) and chlorophyll were measured concurrent with many measurements in P1 and all measures during P2, and temperature with all measures. Water chemistry parameters (NH4-N, NO3-N, PO4-P, SiO2, Cl, SO4, total alkalinity, pH) associated with each run are included in the data set, as are days since storm of various thresholds. Field procedures, analytical methods and data analyses are detailed in Bott, T.L. & J. D. Newbold, 2023. A multi-year analysis of factors affecting ecosystem metabolism in forested and meadow reaches of a Piedmont Stream. Hydrobiologia
Inter- and intra-annual temperature and precipitation variability (1950-2022) across the ranges of non-migratory birds and their association with generation length
While environmental variability is theorized to impact the life history characteristics of organisms, these hypotheses have not been thoroughly tested with empirical data. To fill this gap, we synthesized a global data set of environmental variability metrics and life history characteristics across the ranges of 7,477 non-migratory, non-marine avian species. These data are derived from the ERA5 climate reanalysis, AVONET, BirdTree, and BirdLife databases as well as previously published research. By extracting environmental variability values across individual species' ranges, this data set allows users to evaluate avian species' pace of life in response to environmental change.
Field Evidence of Carbon and Nitrogen Stabilization through Mineral Associated Organic Matter Formation in Coastal Wetland Soils from Apalachicola, Florida, collected in June, 2022.
This data set was used to observe the role of Mineral Associated Organic Matter Formation (MAOM) on biogeochemical soil properties in three coastal wetlands in Apalachicola, Florida. One wetland was restored using beneficial dredged sediment, increasing the soil's inorganic matter content. Soil samples were collected in June 2022 from this wetland and two nearby reference wetlands: one with high organic matter and the other with higher inorganic matter content. The samples were analyzed at the University of Central Florida for biogeochemical properties to determine which properties were most related to MAOM pools.
Soil respiration rates, biogeochemical pools, and mineral-associated organic matter from high organic matter and high mineral content coastal wetland soils in Apalachicola, Florida, 2022
This data set was used to observe how the application of dredged sediment would impact soil respirations rates, biogeochemical pools, mineral associated organic matter of coastal wetland soils from Apalachicola, Florida. To achieve this, a combination of intact core and bottle incubations were used, comparing a high organic matter coastal wetland soil to a high mineral content wetland soil which were collected in June, 2022. All laboratory analysis was conducted at the University of Central Florida in Orlando, Florida.
Ecosystem metabolism and associated modeling parameters for 6 oligotrophic lakes and ponds in a single watershed
This dataset was collected as part of a watershed-scale study to assess impacts of smoke cover on water temperature and rates of ecosystem metabolism in small lakes and ponds. We measured thermal and metabolic responses to smoke in six waterbodies within a high-elevation watershed (watershed area 1908 ha; elevation range 2800-3229 m.a.s.l) located in Sequoia-Kings Canyon National Park in the Sierra Nevada Mountains of California. All lakes and ponds are oligotrophic, and range in maximum depth from 1.5m to 10m. The dataset includes: time series data of dissolved oxygen, water temperature, and environmental parameters relevant to modeling ecosystem metabolism; estimated rates of ecosystem metabolism using the Kalman filter method; descriptive site information including location, size, and depth.
Data associated with the 2019 Freshwater Oil Spill Remediation Study (FOReSt) assessing the use of enhanced Monitored Natural Recovery (eMNR) and shoreline washing agent (SWA) of diluted bitumen spills conducted in shoreline enclosures at the IISD Experimental Lakes Area, ON, Canada from 2019 to 2020
The following package includes data from the 2019 Freshwater Oil spill Remediation Study (FOReSt) at the IISD Experimental Lakes Area studying the use of enhanced monitored natural recovery (eMNR) and shoreline washing agent (SWA) as a secondary remediation method for diluted bitumen spills in freshwater shoreline enclosures. This package includes data tables on polycyclic aromatic compound chemistry in water and sediments, basic water quality, nutrient chemistry, and tritium chemistry monitored in the experimental and reference enclosures, and lake reference sites over the duration of the study. Data included in this package was first collected and used in the paper by Palace et al., titled Polycyclic aromatic compounds in freshwater ecosystems following non-invasive remediation of controlled diluted bitumen spills: The Freshwater Oil Spill Remediation Study (FOReSt) at the Experimental Lakes Area, Canada.
Stable carbon and nitrogen isotope data from Arctic coastscapes associated with coastal invertebrate and fish food webs, 1999-2022
Stable carbon and nitrogen isotope data are commonly used to elucidate food web structure and partition food source importance to consumers. Here, stable isotope data were gathered from across the coastal Arctic to assess how differences in coastal type (i.e., coastscape) and longitudinal region differ across the Arctic. Data were collected between 1999-2022.
Microclimate data associated with green infrastructure in Lancaster Pennsylvania, 2022
Green stormwater infrastructure (GSI) is being increasingly implemented as a stormwater management practice. A key reason for its popularity is the potential for co-benefits, such as heat mitigation, in addition to stormwater management functions. This data is the result of field investigation of heat patterns around GSI in Lancaster, Pennsylvania, providing some of the first ever direct measurements of microclimate and thermal comfort near GSI. During summer 2022, we collected data along transects at 10 rain gardens. Microclimate variables were quantified using a Kestrel 5400 Heat Stress Tracker and were used to calculate metrics that represent heat stress experienced by a human such as wet bulb globe temperature (WBGT) and mean radiant temperature (MRT). Measurements were also made at nearby impervious surface and lawn reference sites.
Summary of tundra pond zooplankton and associated environmental data from the Barrow, AK IBP tundra ponds (1970s & 2010s)
A comparison of historic (1970s) and more recent (2010s) zooplankton and environmental data from Arctic tundra ponds near Utqiaġvik, AK has given us valuable insight into changes in zooplankton communities that have occurred in recent times.
Soil and root-associated fungal response to nitrogen and phosphorus addition from grasslands worldwide: 2011-2012.
Ecosystems across the globe receive elevated inputs of nutrients, but the consequences of this for soil fungal guilds that mediate key ecosystem functions remain unclear. We found that nitrogen and phosphorus addition to 25 grasslands distributed across four continents promoted the relative abundance of fungal pathogens, suppressed mutualists, but did not affect saprotrophs. Structural equation models suggested that responses were often indirect and primarily mediated by nutrient-induced shifts in plant communities. Nutrient addition also reduced co-occurrences within and among fungal guilds, which could have important consequences for belowground interactions. Focusing only on plots that received no nutrient addition, soil properties influenced pathogen abundance globally, whereas plant community characteristics influenced mutualists, and climate influenced saprotrophs. These guild-level responses enhance our ability to predict soil functional responses to anthropogenic eutrophication and the associated longer-term responses of plant communities to this important global change factor.
Periphyton and Associated Environmental Data Relative from Samples Collected from the Greater Everglades, Florida, USA from September 2005 to November 2014
This data package contains peripihyton and environmental data collected annually during the wet season between 2005 and 2014 from sites distributed throughout the greater Everglades ecosystem. This project is part of the Comprehensive Everglades Restoration Program's Monitoring and Assessment Plan intended to document baseline variability in periphyton attributes for assessing the effectiveness of restoration projects. A total of 200 primary sampling units (PSU) of 800 m x 800 m are nested in 32 landscape units and each year, random coordinates are 'drawn' within each PSU and one sampleable draw is visited in each. Sampled periphyton is processed for diatoms, slides are prepared, and 500 frustules are enumerated and identified to the lowest possible taxonomic resolution per slide. Taxon abundances are then relativized to the total count. These data accompany environmental, periphyton biomass, and soft algal abundance datasets.
Nekton individual data from flume net collections along Rowley River tidal creeks associated with long term fertilization experiments, Rowley, MA.
The flume nets were deployed with the purpose of capturing salt marsh nekton. Nekton species were identified to the lowest taxonomic level using species keys. The TIDE project aims to simulate eutrophication on a large scale by the addition of NO3- aiming to reach 70μM concentrations from May to September every year during the growing season. This fertilization of the marsh has been going on at Sweeney Creek since the 2004 growing season through 2016 and at Clubhead Creek in 2005 and from 2009 till 2016. Years 2017-2020 are enrichment recovery years.
Nekton species counts and density from flume net collections along Rowley River tidal creeks associated with long term fertilization experiments, Rowley, MA.
The flume nets were deployed with the purpose of capturing salt marsh nekton. Nekton species were identified to the lowest taxonomic level using species keys. The TIDE project aims to simulate eutrophication on a large scale by the addition of NO3- aiming to reach 70μM concentrations from May to September every year during the growing season. This fertilization of the marsh has been going on at Sweeney Creek since the 2004 growing season through 2016 and at Clubhead Creek in 2005 and from 2009 till 2016. Years 2017-2020 are enrichment recovery years.
Benthic algae chlorophyll measurements for Rowley River tidal creeks associated with long term fertilization experiments, Rowley and Ipswich, MA.
Benthic algae chlorophyll measurements for Rowley River tidal creeks associated with long term fertilization experiments, Rowley and Ipswich, MA.
Marsh plant species shoot height, weight and diameters for Rowley River tidal creeks associated with long term fertilization experiments, Rowley and Ipswich, MA.
Marsh plant species shoot height, weight and diameters for Rowley River tidal creeks associated with long term fertilization experiments, Rowley and Ipswich, MA. The TIDE project aims to simulate eutrophication on a large scale by the addition of NO3- aiming to reach 70μM concentrations from May to September every year during the growing season. This fertilization of the marsh has been going on at Sweeney Creek since the 2004 growing season through 2012 and at Clubhead Creek in 2005 and from 2009 till 2019.
Coastal landcover change and the associated biomass trends in the mid-Atlantic sea-level rise hotspot
Climate change is driving worldwide landscape reorganization. In the coastal ecosystem, climate-driven sea level rise is forcing landward marsh migration and forest die-off, with potentially large consequences on coastal carbon balance. Here we used 30 m resolution Landsat images to study coastal landcover change from 1984 to 2020, and analyzed the Normalized Difference Vegetation Index (NDVI, a proxy of plant biomass) trend between 1984 and 2020 in the mid-Atlantic sea level rise hotspot. Our study region stretches across the entire Chesapeake Bay and the Delaware Bay to encompass all areas between 0-5m above sea level (total area ~12,500 km2). Specifically, the data package includes 3 raster datasets derived from the Landsat images. All datasets cover the identical mid-Atlantic region and have identical spatial resolution of 30 m. The two landcover datasets, named as 'Landcover_year1984.tif' and'Landcover_year2020.tif', respectively refer to landcover map in 1984 and 2020. Each of the maps has 7 landcover classes differentiated by different integers, and they are: water (0), farmland (1), urban area(2), upland forest (3), transition forest (4), marsh (5) and sandbar (6). Both landcover maps were generated using a combination of random forest classification and manual delineation, and the resultswere validated with high-resolution aerial photos and satellite images with an overall mapping accuracybeyond 90%. The third raster dataset, named as 'NDVItrend_1984to2020.tif', is the NDVI trend map. The value of each 30 by 30 m pixel in the map represents the slope of the NDVI trendline estimated using annual peak-growing season NDVI images acquired between 1984 and 2020. Negative values in the dataset represent decreases of NDVI (i.e. biomass loss, or ecosystem browning) from 1984 and 2020,whereas positive values correspond to an increase of NDVI (i.e. biomass gain, or ecosystem greening)between 1984 and 2020. The data package is completed.
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