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ShareScore release 0.9.0
Dataset results
46 results for “Bone marrow plasma”
Single cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment
GEO Series GSE292189. Homo sapiens. 52 samples. Type: Expression profiling by high throughput sequencing; Other.
Bone marrow TTP deficeincy significantly increased inflammation while reduced plasma lipid and hepatic steatosis in LDLR knockout mice
GEO Series GSE126481. Mus musculus. 8 samples. Type: Expression profiling by array.
Antibody microarrays of plasma from bone marrow transplant patients to find markers of graft versus host disease
GEO Series GSE9791. Homo sapiens. 44 samples. Type: Protein profiling by protein array.
Myeloid Skewing in Aging Bone Marrow Depends on Long-lived Plasma Cell Accumulation
GEO Series GSE112939. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Origins and diversity of pan-isotype human bone marrow plasma cells
GEO Series GSE262896. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing; Other.
Gene Expression of Bone Marrow Plasma Cells from Healthy Donors (N=22), MGUS (N=44), and Smoldering Myeloma (N=12)
GEO Series GSE5900. Homo sapiens. 78 samples. Type: Expression profiling by array.
Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow I
GEO Series GSE99634. Homo sapiens. 20 samples. Type: Expression profiling by array.
Transcript profile comparison of Zbtb20-sufficient and Zbtb20-deficient polyclonal bone marrow plasma cells
GEO Series GSE58659. Mus musculus. 8 samples. Type: Expression profiling by array.
Expression data from murine bone marrow-resident plasma cells and spleen mature follicular B cells
GEO Series GSE39916. Mus musculus. 6 samples. Type: Expression profiling by array.
Gene expression in primary human bone marrow plasma cells sorted according to CD19 expression
GEO Series GSE56464. Homo sapiens. 8 samples. Type: Expression profiling by array.
Chimeric hemagglutinin-based universal influenza mRNA vaccine induces protective immunity and bone marrow plasma cells in rhesus macaques
GEO Series GSE304256. Macaca mulatta. 50 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow
GEO Series GSE99636. Homo sapiens. 66 samples. Type: Expression profiling by array.
Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow
GEO Series GSE253862. Homo sapiens. 212 samples. Type: Expression profiling by high throughput sequencing; Other.
Isotype-based plasma cell subsets display differential niches requirements in the bone marrow
GEO Series GSE228543. Mus musculus. 99 samples. Type: Expression profiling by high throughput sequencing.
Significantly decreased hypoxanthine levels in bone marrow plasma of aplastic anemia patients revealed by 800 MHz NMR based metabolomics analysis
<p><strong>Background:</strong> Compared to plasma, the hypoxanthine (HX) concentration is three times higher in the human bone marrow <strong>[R1]</strong> and its availability is crucial to regulate the de novo purine synthesis in human bone marrow <em>in vivo</em> <strong>[R1]</strong>. Studies have shown that circulatory HX levels in the plasma increase in patients with solid tumors and leukemia <strong>[R2]</strong>. Aplastic anemia (AA) is rare disorder of bone marrow failure characterized by hypocellularity and peripheral cytopenias. As purine biosynthesis is essential for normal cell growth and proliferation, we hypothesized that bone marrow HX levels will be decreased in aplastic anemia (AA) patients and may reset back partially in AA patients showing clinical improvement. </p> <p><strong>Aim:</strong> To compare the HX levels in bone marrow plasma samples of AA patients and control subjects and further to check its metabolic reprogramming in AA patients showing clinical improvement. </p> <p><strong>Methods:</strong> The HX levels of bone marrow plasma metabolites were estimated for 56 AA patients and 20 control subjects using 800 MHz NMR spectroscopy. The NMR spectra were analyzed using NMR suite of commercial software (CHENOMX). The levels of altered metabolites in AA patients w.r.t control were estimated and the values are reported as Mean ± SD (SD is standard deviation). The diagnostic potential is evaluated employing standard receiver operating characteristic (ROC) curve analysis.</p> <p><strong>Results:</strong> The present study aims to compare the bone marrow plasma metabolic profiles of hypoxanthine between age and sex matched AA patients (N=40; mean age 32.31±16.03, male/female ratio of 22/18) and follow-up AA patients (N=16) with respect to age matched control subjects (N=20, mean age=39.5±18.48 years, male/female ratio of 11/9). The comparison revealed that the HX levels are significantly decreased in AA patients (HX=3.62 ± 3.17) compared to NC subjects (HX = 20.89 ± 12.73) and improved slightly in follow-up patients (HX=6.21 ±4.77, however no statistically significant change compared to AA patients). Further, the circulatory HX levels exhibit significant diagnostic potential with area under ROC (AUROC) curve values equal to 0.96 [95%CI = 0.92–1.00].</p> <p><strong>Concluding remarks:</strong> The depleted HX levels in the bone marrow plasma suggested altered/compromised purine biosynthesis/metabolism in AA patients and future studies are warranted to underscore its role in the disease pathobiology.</p> <p> </p> <p><strong>Reference:</strong></p> <p>[R1] King, M.E., Honeysett, J.M. and Howell, S.B., 1983. Regulation of de novo purine synthesis in human bone marrow mononuclear cells by hypoxanthine. <em>The Journal of clinical investigation</em>, <em>72</em>(3), pp.965-970.</p> <p>[R2] Wung WE, Howell SB. Hypoxanthine concentrations in normal subjects and patients with solid tumors and leukemia. Cancer research. 1984 Jul;44(7):3144-8.</p>
Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid
ClinicalTrials.gov study NCT02285725. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow II
GEO Series GSE99635. Homo sapiens. 35 samples. Type: Expression profiling by array.
Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells
GEO Series GSE9894. Homo sapiens. 12 samples. Type: Expression profiling by array.
Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow I
GEO Series GSE252959. Homo sapiens. 152 samples. Type: Expression profiling by high throughput sequencing; Other.
Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow III
GEO Series GSE107843. Homo sapiens. 21 samples. Type: Expression profiling by array.
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