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864 results for “Brain function”
Subgraphs of functional brain networks identify dynamical constraints of cognitive control
<p>Post-processed BOLD fMRI functional connectivity data from human subjects performing two distinct cognitive control tasks.</p> <p>See enclosed README file for information regarding data organization and handling.</p>
Functional Coactivation Map of the Human Brain - Figures
<p>These are author versions of the figures of the article "Functional coactivation map of the human brain", <a href="https://doi.org/10.1093/cercor/bhn014">https://doi.org/10.1093/cercor/bhn014</a></p> <p><strong>Fig. 1 (fig1v2.tif)</strong> Characterization of the experiments used in the coactivation map. Distribution of the different cognitive domains represented by the experiments after the BrainMap classification (A). Histogram of the number of locations per experiment (B). Experiments reported on average 8 locations, and a decreasing number of experiments reported large numbers of locations.</p> <p><strong>Fig. 2 (fig2v2.tif)</strong> Reproducibility of the coactivation map. Pairs of partial coactivation maps computed from disjoint random subsets of the total database of experiments were progressively more similar as the number of experiments increased. The plot shows the distribution of the correlation coefficient for 20 pairs of partial coactivation maps computed from independent sets of 500, 700, 900, 1100, 1300, 1500, and 1700 experiments.</p> <p><strong>Fig. 3 (fig-symm.tif)</strong> Symmetric interhemispheric coactivations. Coactivations of regions in the left hemisphere included most of the time the symmetric region in the right hemisphere, and vice versa. The figure shows 3-dimensional reconstructions (A, B) and stereotaxic slices of 4 networks corresponding to 4 seed-voxels in the axial plane z = 28 (C), and 4 networks in the coronal plane y = −6 (D). The network clusters are isosurfaces for P = 0.01, and the location of the seed-voxels is indicated by white squares in the stereotaxic slices.</p> <p><strong>Fig. 4 (fig-ipsl.tif)</strong> Fronto-parietal “attention” network. Three-dimensional reconstruction and axial (z = 48) and para-sagittal (x = 30) stereotaxic slices of the network recovered with a seed-voxel at the left intraparietal sulcus (IPS, x = −26, y = −58, z = 48). It includes the supplementary motor area (SMA) and preSMA, left and right anterior insula (aIns), frontal eye fields (FEF), dorsolateral prefrontal cortex (DLPFC), inferior precentral sulcus (iPCS), ventral occipital cortex (vOC), inferior parietal lobule (iPL), and the ventral IPS (vIPS). The network clusters are isosurfaces for P = 0.01, and the location of the seed-voxel is indicated in the axial slice by a white square.</p> <p><strong>Fig. 5 (fig-acc.tif) </strong>Cingulo-parietal “resting state” network. Three-dimensional reconstructions and sagittal stereotaxic slice (x = −2) of the network recovered with a seed-voxel at the anterior cingulate cortex (aCC, x = −2, y = 46, z = −4). It includes the posterior cingulate cortex (pCC), nucleus accumbens (NA), lateral parietal cortex (LPC), inferior temporal cortex (iTC), and the superior frontal cortex (SFC). The network clusters are isosurfaces for P = 0.01 (strong red), and P = 0.5 (in transparency). The location of the seed-voxel is indicated by a white square in the sagittal slice.</p> <p><strong>Fig. 6 (fig-motor.tif)</strong> Cortico-diencephalo-cerebellar “motor” network. Three-dimensional reconstructions and coronal (y = −26) and para-sagittal (x = −34) stereotaxic slices of the network recovered with a seed-voxel at the dorsal part of the left central sulcus (CS, x = −34, y = −26, z = 60). The network includes the right central sulcus, caudal cingulate motor area (CMA), ipsilateral putamen (Pu), thalamus (Th), and left cerebellum (Cb-L), and the contralateral anterior lobe of the cerebellum (aCb). The network clusters are isosurfaces for P = 0.01, and the seed-voxel is indicated by white squares in the coronal and sagittal slices.</p>
Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury
ClinicalTrials.gov study NCT03854214. IPD Sharing: YES. Countries: 1. Publications: 4.
Whole-brain mapping in adult zebrafish and identification of the functional brain network underlying the novel tank test
Open the record for dataset details and reuse information.
Functional networks in the infant brain during sleep and wake states
Open the record for dataset details and reuse information.
Data from: Brain functional networks associated with social bonding in monogamous voles
<p>Previous studies have related pair bonding in Microtus ochrogaster, the prairie vole, with plastic changes in several brain regions. However, the interactions between these socially-relevant regions have yet to be described. In this study, we used resting state magnetic resonance imaging to explore bonding behaviors and functional connectivity of brain regions previously associated with pair bonding. Thirty-two male and female prairie voles were scanned at baseline, 24h and 2 weeks after the onset of cohabitation. By using network based statistics, we identified that the functional connectivity of a cortico-striatal network predicted the onset of affiliative behavior, while another predicted the amount of social interaction during a partner preference test. Furthermore, a network with significant changes in time was revealed, also showing associations with the level of partner preference. Overall, our findings revealed the association between network-level functional connectivity changes and social bonding.</p>
Data from: Reconfiguration of functional brain networks and metabolic cost converge during task performance
<p>The ability to solve cognitive tasks depends upon adaptive changes in the organization of whole-brain functional networks. However, the link between task-induced network reconfigurations and their underlying energy demands is poorly understood. We address this by multimodal network analyses integrating functional and molecular neuroimaging acquired concurrently during a complex cognitive task. Task engagement elicited a marked increase in the association between glucose consumption and functional brain network reorganization. This convergence between metabolic and neural processes was specific to feedforward connections linking the visual and dorsal attention networks, in accordance with task requirements of visuo-spatial reasoning. Further increases in cognitive load above initial task engagement did not affect the relationship between metabolism and network reorganization but only modulated existing interactions. Our findings show how the upregulation of key computational mechanisms to support cognitive performance unveils the complex, interdependent changes in neural metabolism and neuro-vascular responses.</p>
Neonatal brain dynamic functional connectivity: impact of preterm birth and association with early childhood neurodevelopment (data)
<p>Neonatal brain dynamic functional connectivity: impact of preterm birth and association with early childhood neurodevelopment</p>
Causal functional maps of brain rhythms in working memory
<p>Results of the meta-modeling of transcranial alternating current stimulation (tACS) studies in working memory. Two files are for theta and gamma maps in MNI brain space. The files accompany the paper "Causal functional maps of brain rhythms in working memory" by Miles Wischnewski*, Taylor A Berger, Alexander Opitz, and Ivan Alekseichuk**. Correspondance: *m.wischnewski@rug.nl or **ialeksei@umn.edu</p> <p> </p>
Data from: Changes in brain structure and function following exposure to oral LSD during adolescence: A multimodal MRI study
<p><em>Background</em>: LSD is a hallucinogen with complex neurobiological and behavioral effects. Underlying these effects are changes in brain neuroplasticity. This is the first study to follow the developmental changes in brain structure and function following LSD exposure in periadolescence. We hypothesized LSD given during a time of heightened neuroplasticity, particularly in the forebrain, would affect cognitive and emotional behavior and the associated underlying neuroanatomy and neurocircuitry. </p> <p><em>Methods:</em> Female and male mice were given vehicle, single, or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90-120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivity between experimental groups.</p> <p><em>Results:</em> Motor behavior and cognitive performance were unaffected by periadolescent exposure to LSD. Differences across experimental groups in brain volume for any of the 139 brain areas were few in number and not focused on any specific brain region. Multiple exposures to LSD significantly altered gray matter microarchitecture across much of the brain. These changes were primary associated with the thalamus, sensory and motor cortices, and basal ganglia. The forebrain olfactory system and prefrontal cortex and hindbrain cerebellum and brainstem were unaffected. The functional connectivity between forebrain white matter tracts and sensorimotor cortices and hippocampus was reduced with multidose LSD exposure.</p> <p><em>Conclusion:</em> Does early exposure to LSD in periadolescence have lasting effects on brain development? There was no evidence of LSD having consequential effects on cognitive or motor behavior when animal were evaluated as young adults 90-120 days of age. Neither were there any differences in the volume of specific brain areas between experimental conditions. The pronounced changes in indices of anisotropy across much of the brain would suggest altered gray matter microarchitecture and neuroplasticity. The reduction in connectivity in forebrain white matter tracts with multidose LSD and consolidation around sensorimotor and hippocampal brain areas requires a battery of tests to understand the consequences of these changes on behavior.</p>
Figure 3. Describing the sequence of input sensations sent by the system.-Designing a Growing Functional Modules "Artificial Brain"
<p>To design the controller, first of all, the user should click the button “new” on the toolbar to<br> create an empty canvas and to assign it a controller's name, presently “pathfinder”. Then, the first<br> convenient step is to describe the feedback given by the system as a sequence of sensations (see<br> figure 3). The first sensation named “free”, indicates if the vehicle has been able or not to cross the<br> range of obstacles. Each of the next sixteen values is associated to its corresponding proximity<br> sensors that points out the presence of an obstacle. They are given a name beginning with “s”<br> followed by a number. The red color of the last sensation's field indicates that the given name is<br> invalid; presently, because it contains a blank character.</p>
Data from: Structural and functional brain connectome in motor neuron diseases: a multicenter MRI study
Objective. To investigate structural and functional neural organization in amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA) patients. Methods. 173 ALS, 38 PLS, 28 PMA sporadic patients and 79 healthy controls were recruited from three Italian centers. Subjects underwent clinical, neuropsychological and brain MRI evaluations. Using graph analysis and connectomics, global and lobar topological network properties and regional structural and functional brain connectivity were assessed. The association between structural and functional network organization and clinical/cognitive data was investigated. Results. Compared to healthy controls, ALS and PLS patients showed altered structural global network properties, as well as local topological alterations and decreased structural connectivity in sensorimotor, basal ganglia, frontal and parietal areas. PMA patients showed preserved global structure. Patient groups did not show significant alterations of functional network topological properties relative to controls. Increased local functional connectivity was observed in ALS patients in the precentral, middle and superior frontal areas, and in PLS patients in the sensorimotor, basal ganglia and temporal networks. In both ALS and PLS patients, structural connectivity alterations correlated with motor impairment, while functional connectivity disruption was closely related to executive dysfunctions and behavioral disturbances. Conclusions. This multicenter study showed widespread motor/extra-motor network degeneration in ALS and PLS, suggesting that graph analysis and connectomics might represent a powerful approach to detect upper motor neuron degeneration, extra-motor brain changes and network reorganization associated with the disease. Network-based advanced MRI provides an objective in vivo assessment of motor neuron diseases, delivering potential prognostic markers.
Brain functional connectivity in chronic tic disorders and Gilles de la Tourette syndrome
<p>The pathophysiology of chronic tic disorder (cTD) and Gilles de la Tourette syndrome (GTS) is characterized by the dysfunction of both motor and non - motor cortico - striatal - thalamo - cortical (CSTC) circuitries, which leads to tic release and comorbids. A role of fronto - parietal network (FPN) connectivity breakdown has been postulated for tic pathogenesis, given that the FPN entertain connections with limbic, paralimbic, and CSTC networks. Our study was aimed at characterizing the FPN functional connectivity in cTD and GTS in order to assess the role of its deterioration in tic severity and the degree of comorbids. We recorded scalp EEG during resting state in patients with cTD and GTS. The eLORETA current source densities were analyzed, and the lagged phase synchronization (LPS) was calculated to estimate nonlinear functional connectivity between cortical areas. We found that the FPN functional connectivity in delta band was more detrimental in more severe GTS patients. Also, the sensorimotor functional connectivity in beta2 band was stronger in more severe cTD and GTS patients. FPN functional connectivity deterioration correlated with comorbids presence and severity in patients with GTS. Our data suggest that a FPN disconnection may contribute to the motoric symptomatology and comorbid severity in GTS, whereas sensorimotor disconnection may contribute to tic severity in cTD and GTS. Although preliminary, our study points out a differently disturbed brain connectivity between patients with cTD and GTS. This may serve as diagnostic marker and potentially interesting base to develop pharmacological and noninvasive neuromodulation trials aimed at reducing tic symptomatology.</p>
Immersive Functional Virtual Reality in People With Acquired Brain Injury and Unilateral Spatial Neglect
ClinicalTrials.gov study NCT07017140. IPD Sharing: NO. Countries: 1. Publications: 5.
Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence
ClinicalTrials.gov study NCT00385801. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Does Glaucoma Cause Loss of Brain Function?
ClinicalTrials.gov study NCT01303939. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Photobiomodularion on Brain Connectivity and Cognitive Function in Cognitive Impairment
ClinicalTrials.gov study NCT07287527. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Ibuprofen Effects on Brain Function
ClinicalTrials.gov study NCT02507219. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function
ClinicalTrials.gov study NCT02460783. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Trial Comparing Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Parkinson's Disease
ClinicalTrials.gov study NCT02401308. IPD Sharing: NO. Countries: 1. Publications: 8.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.