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Dataset results
93 results for “C-reactive protein”
Optimizing the Care Pathway of Febrile Children Via Capillary C-reactive Protein Assay in Primary Care
ClinicalTrials.gov study NCT06910631. IPD Sharing: YES. Countries: 1. Publications: 1.
Effect of Short-term Prednisone Therapy on C-reactive Protein in Patients With Acute Heart Failure
ClinicalTrials.gov study NCT05916586. IPD Sharing: NO. Countries: 1. Publications: 25.
Neutrophil-to-lymphocyte Ratio vs C-reactive Protein as Early Predictors of Anastomotic Leakage After Colorectal Surgery
ClinicalTrials.gov study NCT04673110. IPD Sharing: NO. Countries: 0. Publications: 7.
C-reactive Protein (CRP)-Guided Management Algorithm for Adults With Acute Cough
ClinicalTrials.gov study NCT00221351. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Exercise on Elevated C-reactive Protein Concentrations in Formerly Inactive Adults
ClinicalTrials.gov study NCT00113061. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Relationship between c-reactive protein-albumin ratio and prognosis in pediatric patients with severe burns
Open the record for dataset details and reuse information.
Figure 1 from: Althanoon ZA, Mahmood IH (2021) Effect of lisinopril therapy on serum leptin, oxidative stress and C-reactive protein in hypertensive patients. Pharmacia 68(3): 705-711. https://doi.org/10.3897/pharmacia.68.e73140
Figure 1 The difference in mean of measured parameters (MDA, hsCRP, TAC, and GSH) among the study sampled groups.
Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Acute Pancreatitis
ClinicalTrials.gov study NCT03830060. IPD Sharing: Not stated. Countries: 0. Publications: 4.
C-reactive Protein & Albumin Ratio IN AKI
ClinicalTrials.gov study NCT07335757. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
Systemic Inflammation Response Index and C-Reactive Protein to Albumin Ratio in Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT06674850. IPD Sharing: UNDECIDED. Countries: 0. Publications: 3.
Serum Total Homocysteine and C-Reactive Protein - Ancillary to IDNT
ClinicalTrials.gov study NCT00021918. IPD Sharing: Not stated. Countries: 0. Publications: 3.
High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese Women
ClinicalTrials.gov study NCT01763528. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effects of Blood Pressure Reduction on High Sensitivity C-Reactive Protein (hsCRP)
ClinicalTrials.gov study NCT00154271. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Diagnostic Value of C-reactive Protein and White Blood Cell Counts for Early Detection of Inflammatory Complications After Open Resection of Colorectal Cancer
ClinicalTrials.gov study NCT01221324. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effect of Enhanced Recovery After Surgery (ERAS) on C-reactive and Visceral Proteins
ClinicalTrials.gov study NCT02348229. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Enhanced Trained Immunity in Peripheral Monocytes in Unstable Angina With Elevated High-Sensitivity C-Reactive Protein
GEO Series GSE309139. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Data from: Baseline C-reactive protein level and life prognosis in Parkinson disease
Background: C-reactive protein (CRP) is a biomarker of inflammation, and high levels of CRP correlate with vascular death. Chronic inflammation is considered to be involved in neurodegeneration, although there is no evidence linking it with the process of neurodegenerative diseases. Objective: To determine the role of baseline CRP levels in the prognosis of patients with Parkinson disease (PD). Methods: A cohort of 313 patients with a mean age of 69.1 and mean PD duration of 7.9 years was retrospectively followed for a mean observation time of 1,753 days. CRP was measured when patients were not diagnosed with any infections, and levels were repetitively measured to investigate a tendency of "regression to mean." The primary outcome measure was a survival time from study enrollment to death. Results: During the observation period 56 patients died. Baseline CRP was log-linearly associated with a risk of death in PD. Mean survival time was 3,149 (95% confidence interval; 3,009-3,289) days in patients with CRP ≤ 0.8mg/L (lower two thirds) and 2,620 (2,343-2,897) days in those with CRP > 0.8 mg/L (top third, p < 0.001, log-rank test). The adjusted hazard ratio (HR) per two-fold higher CRP concentration for all deaths was 1.29 (1.10-1.52), and after excluding PD-unrelated deaths, such as cancer or stroke, HR was 1.23 (1.01-1.49) (adjusted for age, sex, PD duration, modified Hohen-Yahr stages, MMSE scores, and serum albumin). Conclusions: Baseline CRP concentrations were associated with the risk of death and predicted life prognosis of patients with PD. The associations were independent from PD duration, PD severity, cognitive function, ages, and nutritional conditions, suggesting the possibility that subclinical chronic inflammation is associated with a neurodegenerative process in PD.
Data from: Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice
C-reactive protein (CRP), was recently reported to be closely associated with poor renal function in patients with acute kidney injury (AKI), but whether CRP is pathogenic or a mere biomarker in AKI remains largely unclear. Impaired autophagy is known to exacerbate renal ischemia-reperfusion injury (IRI). We examined whether the pathogenic role of CRP in AKI is associated with reduction of autophagy. We mated transgenic rabbit CRP over-expressing mice (Tg-CRP) with two autophagy reporter mouse lines, Tg-GFP-LC3 mice (LC3) and Tg-RFP-GFP-LC3 mice (RG-LC3) respectively to generate Tg-CRP-GFP-LC3 mice (PLC3) and Tg-CRP-RFP-GFP-LC3 mice (PRG-LC3). AKI was induced by IRI. Compared with LC3 mice, PLC3 mice developed more severe kidney damage after IRI. Renal tubules were isolated from LC3 mice at baseline for primary culture. OKP cells were transiently transfected with GFP-LC3 plasmid. CRP addition exacerbated lactate dehydrogenase release from both cell types. Immunoblots showed lower LC-3 II/I ratios and higher levels of p62, markers of reduced autophagy flux, in the kidneys of PLC3 mice compared to LC3 mice after IRI, and in primary cultured renal tubules and OKP cells treated with CRP and H2O2 compared to H2O2 alone. Immunohistochemistry showed much fewer LC-3 punctae, and electron microscopy showed fewer autophagosomes in kidneys of PLC3 mice compared to LC3 mice after IRI. Similarly, CRP addition reduced GFP-LC3 punctae induced by H2O2 in primary cultured proximal tubules and in GFP-LC3 plasmid transfected OKP cells. Rapamycin, an autophagy inducer, rescued impaired autophagy and reduced renal injury in vivo. In summary, it was suggested that CRP be more than mere biomarker in AKI, and render the kidney more susceptible to ischemic/oxidative injury, which is associated with down-regulating autophagy flux.
Dataset related to article "Optimal Predictors of Postoperative Complications After Gastrectomy: Results from the Procalcitonin and C-reactive Protein for the Early Diagnosis of Anastomotic Leakage in Esophagogastric Surgery (PEDALES) Study"
<p>This record contains raw data related to article "Optimal Predictors of Postoperative Complications After Gastrectomy: Results from the Procalcitonin and C-reactive Protein for the Early Diagnosis of Anastomotic Leakage in Esophagogastric Surgery (PEDALES) Study"</p><p><strong>Abstract</strong></p><p><strong>Background: </strong>The aim of this study was to define whether procalcitonin (PCT) is an earlier and more accurate predictor than C-reactive protein (CRP) for anastomotic leakage (AL) and major infective complications (MICs).</p><p><strong>Methods: </strong>This was a prospective multicentric observational study conducted in three Italian centers, including all patients undergoing gastrectomy from May 2016 to April 2021. The endpoint was the assessment of the discrimination and accuracy achieved by the PCT and CRP values measured from POD1 to POD7 for predicting the occurrence of AL and MICs. Accuracy was assessed by calculating the area under the receiver operating curve (AUROC) values and Youden's statistics. Two charts were created for risk stratification during the postoperative course.</p><p><strong>Results: </strong>The rate of AL was 4.6%, with a median day of occurrence on POD5 (range 3-26). The overall rate of major infective complications was 19.9%, with a median day of occurrence on POD6 (range 2-30). PCT showed a significant association with AL on POD6 and POD7 and a significant association with MICs on POD2, while CRP values showed a significant association with AL on POD4 and a significant association with MICs on POD1. No difference in the prediction of AL was observed between PCT and CRP, while CRP was found to be a superior predictor of major infective complications on POD5 (p = 0.024) and POD7 (p = 0.035).</p><p><strong>Conclusions: </strong>PCT was not superior to CRP as an early predictor of AL and major infective complications after gastrectomy. CRP should be used as the reference screening postoperative marker.</p>
C-reactive Protein，Homocysteine，Postoperative Delirium
ClinicalTrials.gov study NCT05164965. IPD Sharing: NO. Countries: 1. Publications: 0.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.