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ShareScore release 0.9.0
Dataset results
38 results for “Chemical mechanism”
Data from: Phylogenomic mining of the mints reveals multiple mechanisms contributing to the evolution of chemical diversity in Lamiaceae
The evolution of chemical complexity has been a major driver of plant diversification, with novel compounds serving as key innovations. The species-rich mint family (Lamiaceae) produces an enormous variety of compounds that act as attractants and defense molecules in nature and are used widely by humans as flavor additives, fragrances, and anti-herbivory agents. To elucidate the mechanisms by which such diversity evolved, we combined leaf transcriptome data from 48 Lamiaceae species and four outgroups with a robust phylogeny and chemical analyses of three terpenoid classes (monoterpenes, sesquiterpenes, iridoids) that share and compete for precursors. Our integrated chemical-genomic-phylogenetic approach revealed that: 1) gene family expansion rather than increased enzyme promiscuity of terpene synthases is correlated with mono- and sesqui-terpene diversity; 2) differential expression of core genes within the iridoid biosynthetic pathway is associated with iridoid presence/absence; 3) generally, production of iridoids and canonical monoterpenes appeared to be inversely correlated; and 4) iridoid biosynthesis was significantly associated with expression of geraniol synthase, which diverts metabolic flux away from canonical monoterpenes, suggesting that competition for common precursors can be a central control point in specialized metabolism. These results suggest that multiple mechanisms contributed to the evolution of chemodiversity in this economically important family.
Fig. 7. A. Depsides rearrangement mechanisms with K in Intramolecular transesterification of depsides yields fluorescent 1H-isochromen-1-ones: Application as a chemical probe for lichen determination
Fig. 7. A. Depsides rearrangement mechanisms with K; B. MS fragmentation.
Mechanisms of cyto-toxicity of chemical agents to giant cell tumor: an in-vitro study
Open the record for dataset details and reuse information.
Data from: Phylogenomic mining of the mints reveals multiple mechanisms contributing to the evolution of chemical diversity in Lamiaceae
Open the record for dataset details and reuse information.
Chemical profiling of Jianwei Xiaoshi oral liquid and its potential mechanism of effect on high-calorie diet-induced dyspepsia in immature rats: gut flora, transcriptomics and network pharmacology
GEO Series GSE245835. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Dynamic m6A mRNA methylation reveals novel insights into mechanisms of chemical carcinogenesis
GEO Series GSE112970. Homo sapiens. 14 samples. Type: Methylation profiling by high throughput sequencing.
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders via chemical genetics [Hybrid capture]
GEO Series GSE198279. Homo sapiens. 7 samples. Type: Other.
Cellular generation of 5-Hydroxymethylcytosine by redox-active chemicals via an unprecedent non-enzymatic mechanism
GEO Series GSE44457. Homo sapiens. 4 samples. Type: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Chemical Systems Biology Reveals Mechanisms of Dissociated Glucocorticoid Receptor Signaling
GEO Series GSE149453. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders via chemical genetics
GEO Series GSE198280. Homo sapiens. 45 samples. Type: Other.
9-10-1069 Cloud activation by oxidation of oleic acid by ozone: what is the chemical mechanism?
<p>Binned neutron reflectivity data for the titled experiment</p>
Data related to: MACHINE LEARNING AND QUANTUM MECHANICS APPROACH TO MORE CHEMICALLY-AWARE MOLECULAR DESCRIPTORS FOR MEDICINAL CHEMISTRY APPLICATIONS
<p>DEMIN VS QM ELECTRONIC POTENTIAL CORRELATIONS FOR THE N:= ATOM TYPE AND THE N1 ATOM TYPE</p> <p>dEmin versus H-bond basicity scale and H-bond acidity scale </p>
Effects of Mechanical, Chemical, and Combination Methods on Halitosis
ClinicalTrials.gov study NCT06890104. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Fetal Reduction: Mechanical vs Chemical
ClinicalTrials.gov study NCT03473158. IPD Sharing: NO. Countries: 1. Publications: 0.
Mechanical-chemical Gingival Therapy in Diabetics and/or Obese
ClinicalTrials.gov study NCT02123563. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptome analysis of Aspergillus oryzae RIB40 under chemical stress reveals mechanisms of adaptation to fungistatic compounds of lignocellulosic side streams
GEO Series GSE296876. Aspergillus oryzae. 83 samples. Type: Expression profiling by high throughput sequencing.
A neuroanatomical mechanism linking perinatal chemical exposure to prostate smooth muscle hyperactivity and altered voiding function
GEO Series GSE166395. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Chemical inhibition of APE1 redox and DNA repair functions affects the inflammatory response via different but overlapping mechanisms.
GEO Series GSE182813. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.