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421
datasets available to search
ShareScore release 0.9.0
Dataset results
421 results for “Disease Diagnosis”
Fetuin-A, a Promising Serum Biomarker for Diagnosis of Non-Alcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT06097039. IPD Sharing: NO. Countries: 1. Publications: 6.
Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease
ClinicalTrials.gov study NCT00984308. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Usefulness of α-synuclein as a Marker for Early Diagnosis of Parkinson's Disease in Skin Biopsy.
ClinicalTrials.gov study NCT01380899. IPD Sharing: NO. Countries: 1. Publications: 10.
Volatilome and Single-Lead Electrocardiogram Optimize Ischemic Heart Disease Diagnosis Using Machine Learning Models
ClinicalTrials.gov study NCT06181799. IPD Sharing: NO. Countries: 1. Publications: 8.
The Clinical Diagnosis Meaning of MIF in Coronary Heart Disease
ClinicalTrials.gov study NCT01750502. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease
ClinicalTrials.gov study NCT02545049. IPD Sharing: NO. Countries: 48. Publications: 20.
Precision Diagnosis of Acute Infectious Diseases; Neuroinflammatory Cohort
ClinicalTrials.gov study NCT02910037. IPD Sharing: YES. Countries: 1. Publications: 9.
Diagnosis of prion diseases by RT-QuIC results in improved surveillance
Open the record for dataset details and reuse information.
Data from: Targeted next-generation sequencing panels in the diagnosis of Charcot Marie Tooth disease
Objective: To investigate the effectiveness of targeted NGS panels in achieving a molecular diagnosis in CMT and related disorders in a clinical setting Methods: We prospectively enrolled 220 patients from two tertiary referral centres, one in London, UK (n=120) and one in Iowa, US (n=100) in whom a targeted CMT NGS panel had been requested as a diagnostic test. PMP22 duplication/deletion was previously excluded in demyelinating cases. We reviewed the genetic and clinical data upon completion of the diagnostic process. Results: After targeted NGS sequencing a definite molecular diagnosis, defined as a pathogenic or likely pathogenic variant, was reached in 30% of cases (n=67). The diagnostic rate was similar in London (32%) and Iowa (29%). Variants of unknown significance were found in an additional 33% of cases. Mutations in GJB1, MFN2, MPZ accounted for 39% of cases who received genetic confirmation, while the remainder of positive cases had mutations in diverse genes, including SH3TC2, GDAP1, IGHMBP2, LRSAM1, FDG4, GARS and another 12 less common genes. Copy number changes in PMP22, MPZ, MFN2, SH3TC2 and FDG4 were also accurately detected. A definite genetic diagnosis was more likely in cases with an early onset, a positive family history of neuropathy or consanguinity and a demyelinating neuropathy. Conclusions: NGS panels are effective tools in the diagnosis of CMT leading to the genetic confirmation in one third cases negative for PMP22 duplication/deletion, thus highlighting how rarer and previously undiagnosed subtypes represent today a relevant part of the genetic landscape of CMT.
GWAS Summary data generated for study: disease clusters and their genetic determinants following a diagnosis of depression
<p>Second version of GWAS summary data</p> <p>A1: effect allele</p> <p>A2: other allele</p> <p>Project github page: https://github.com/HZcohort/3D-Disease-Network</p>
Computerized analysis of hypomimia and hypokinetic dysarthria for improved diagnosis of Parkinson's disease
<p>Background and Objective: An aging society requires easy-to-use approaches for diagnosis and monitoring of neurodegenerative disorders, such as Parkinson's disease (PD), so that clinicians can effectively adjust a treatment policy and improve patients' quality of life. Current methods of PD diagnosis and monitoring usually require the patients to come to a hospital, where they undergo several neurological and neuropsychological examinations. These examinations are usually time consuming, expensive, and performed just a few times per year. Hence, this study explores the possibility of fusing computerized analysis of hypomimia and hypokinetic dysarthria (two motor symptoms manifested in the majority of PD patients) with the goal of proposing a new methodology of PD diagnosis that could be easily integrated into mHealth systems. Methods: We enrolled 73 PD patients and 46 age- and gender-matched healthy controls, who performed several speech/voice tasks while recorded by a microphone and a camera. Acoustic signals were parametrized in the fields of phonation, articulation and prosody. Video recordings of a face were analyzed in terms of facial landmarks movement. Both modalities were consequently modeled by the XGBoost algorithm. Results: The acoustic analysis enabled diagnosis of PD with 77% balanced accuracy, while in the case of the facial analysis, we observed 81% balanced accuracy. The fusion of both modalities increased the balanced accuracy to 83% (88% sensitivity and 78% specificity). The most informative speech exercise in the multimodality system turned out to be a tongue twister. Additionally, we identified muscle movements that are characteristic of hypomimia. Conclusions: The introduced methodology, which is based on the myriad of speech exercises likewise audio and video modality, allows for the detection of PD with an accuracy of up to 83%. The speech exercise - tongue twisters occurred to be the most valuable from the clinical point of view. Additionally, the clinical interpretation of the created models is illustrated. The presented computer-supported methodology could serve as an extra tool for neurologists in PD detection and the proposed potential solution of mHealth will facilitate the patient's and doctor's life</p>
Knowledge base for rice plant disease diagnosis
<p>This dataset describes symptoms, disease, and their relationships in rice plant disease.</p>
Full Thickness vs. Rectal Suction Biopsy in the Diagnosis of Hirschsprungs Disease
ClinicalTrials.gov study NCT05307419. IPD Sharing: NO. Countries: 1. Publications: 10.
Vibration Response Imaging in the Diagnosis of Pulmonary Disease
ClinicalTrials.gov study NCT00719784. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Use of Fractionated Exhaled Nitric Oxide in the Diagnosis and Assessment of Disease Activity of Eosinophilic Esophagitis (Validation Phase)
ClinicalTrials.gov study NCT04941742. IPD Sharing: NO. Countries: 1. Publications: 1.
Towards the Validation of a New Blood Biomarker for the Early Diagnosis of Parkinson's Disease
ClinicalTrials.gov study NCT05385315. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders
ClinicalTrials.gov study NCT02105714. IPD Sharing: Not stated. Countries: 4. Publications: 2.
Predictive Value of Cognitive Tests Performed for the Diagnosis of Alzheimer's Disease and Related Disorders
ClinicalTrials.gov study NCT01316562. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Urine Metabolites in the Diagnosis of Disease
ClinicalTrials.gov study NCT06710067. IPD Sharing: NO. Countries: 1. Publications: 5.
Monitoring of Implant Diseases: Diagnosis and Monitoring with AMMP-8 Test Technology
ClinicalTrials.gov study NCT06761521. IPD Sharing: NO. Countries: 1. Publications: 4.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.