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107 results for “Drug exposure”
Assessment of Drug-drug Interactions Between Masculinizing Hormone Therapy and Antiretroviral Agents Concomitantly for Pre-exposure Prophylaxis Among Transgender Men
ClinicalTrials.gov study NCT04593680. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Drug Exposure and Minimum Inhibitory Concentration in the Treatment of MAC Lung Disease
ClinicalTrials.gov study NCT05824988. IPD Sharing: NO. Countries: 1. Publications: 11.
Assessment of Drug-drug Interactions Between Feminizing Hormone Therapy and Emtricitabine/Tenofovir Alafenamide Concomitantly for Pre-exposure Prophylaxis Among Transgender Women
ClinicalTrials.gov study NCT04590417. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Risks of 23 specific malformations associated with prenatal exposure to ten antiepileptic drugs
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Data from: Evaluation of exposure to effervescent drugs in a large health check-up population in France: a cross-sectional study
OBJECTIVES: The relationship between high dietary sodium intake and hypertension is well established. Some drugs are associated with high-sodium content, particularly effervescent tablets (ETs). Despite a possible cardiovascular risk associated with the use of such drugs, observational data describing exposure to ETs in ambulatory subjects are lacking. The aim of this study was to estimate the prevalence of exposure to ETs, and to highlight factors associated with this exposure, in a large French health check-up population. DESIGN: This was cross-sectional study. SETTING AND PARTICIPANTS: Participants were French individuals who underwent medical check-ups at the Investigations Préventives et Cliniques center between April and June 2017. RESULTS: In total, 1,043 subjects were included in the study. The prevalence of exposure to ETs in the last 30 days was 26.9% (95% CI: 24.2 – 29.6). Exposure was frequent (i.e. two ETs per week or more in the last 30 days) for 7.3% of subjects. Self-medication was the major source of exposure (93.8%). Paracetamol, aspirin, vitamins, and betaine accounted for 95.3% of the ETs used. The factors associated with this exposure by multivariate analysis were: male gender, Overseas French origin, depression and body mass index ≥ 25 kg.m-2. A diagnosis of hypertension or treatment with diuretics were not protective factors against exposure to ETs. CONCLUSION: Exposure to ETs is frequent in the general population, particularly through self-medication. Clinical conditions associated with low-salt requirements were not associated with lower exposure to ETs, suggesting a lack of awareness by practitioners and patients about this iatrogenic issue.
Data from: Exposure to phages has little impact on the evolution of bacterial antibiotic resistance on drug concentration gradients
The use of phages for treating bacterial pathogens has recently been advocated as an alternative to antibiotic therapy. Here we test a hypothesis that bacteria treated with phages may show more limited evolution of antibiotic resistance as the fitness costs of resistance to phages may add to those of antibiotic resistance, further reducing the growth performance of antibiotic-resistant bacteria. We did this by studying the evolution of phage-exposed and phage-free Pseudomonas fluorescens cultures on concentration gradients of single drugs, including cefotaxime, chloramphenicol, and kanamycin. During drug treatment, the level of bacterial antibiotic resistance increased through time, and was not affected by the phage treatment. Exposure to phages did not cause slower growth in antibiotic-resistant bacteria, although it did so in antibiotic-susceptible bacteria. We observed significant reversion of antibiotic resistance after drug use being terminated, and the rate of reversion was not affected by the phage treatment. The results suggest that the fitness costs caused by resistance to phages are unlikely to be an important constraint on the evolution of bacterial antibiotic resistance in heterogeneous drug environments. Further studies are needed for the interaction of fitness costs of antibiotic resistance with other factors.
Relative Drug Exposures Of Two Formulations of PF-02341066
ClinicalTrials.gov study NCT00939731. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Drug Exposure and Depot Medroxyprogesterone Acetate (DMPA) in Adolescent Subjects
ClinicalTrials.gov study NCT01461824. IPD Sharing: NO. Countries: 1. Publications: 0.
Drug Exposure Feedback and Education for Nurses' Safety
ClinicalTrials.gov study NCT02283164. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs
ClinicalTrials.gov study NCT07199335. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study Comparing the Drug Exposure in Humans After Administration of a 50 mg Tablet of Sertraline Hydrochloride as Compared to a 50 mg Capsule of Sertraline Hydrochloride Under Fasted (Nonfed) Condit
ClinicalTrials.gov study NCT01235195. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Evaluation of exposure to effervescent drugs in a large health check-up population in France: a cross-sectional study
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Data from: Exposure to phages has little impact on the evolution of bacterial antibiotic resistance on drug concentration gradients
Open the record for dataset details and reuse information.
Repression of stress-induced LINE-1 expression protects cancer cell populations from lethal drug-exposures [ATAC-Seq]
GEO Series GSE100750. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Drug intervention of radiation exposure induced BBB injury via mitochondria-mediated non-infectious inflammation
GEO Series GSE280304. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles of HMEC-1 after exposure to the chemotherapeutic drugs bleomycin and cisplatin with untreated samples as control
GEO Series GSE62523. Homo sapiens. 104 samples. Type: Expression profiling by array.
Exposure to the antiretroviral drug dolutegravir impairs structure and neurogenesis in a forebrain organoid model of human embryonic cortical development
GEO Series GSE275931. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Repression of stress-induced LINE-1 expression protects cancer cell populations from lethal drug-exposures [RNA-Seq]
GEO Series GSE100751. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Gene expression changes in SHI-1 cells following exposure to disulfiram/copper, niclosamde or combined drugs
GEO Series GSE262673. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Drug-tolerant cancer cell persisters survive lethal exposures by silencing transposable elements [ChIP-Seq]
GEO Series GSE74179. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
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