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178 results for “Environmental Exposure*”
Magnitude-duration relationships of physiological sensitivity and environmental exposure improve climate change vulnerability assessments
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Overcoming the congenitally disadvantageous mutation through adaptation to environmental UV exposure in land snails
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Data from: Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent
Wildlife inhabiting environments contaminated by radionuclides face putative detrimental effects of exposure to ionizing radiation, with biomarkers such as an increase in DNA damage and/or oxidative stress commonly associated with radiation exposure. To examine the effects of exposure to radiation on gene expression in wildlife, we conducted a de novo RNA sequencing study of liver and spleen tissues from a rodent, the bank vole Myodes glareolus. Bank voles were collected from the Chernobyl Exclusion Zone (CEZ), where animals were exposed to elevated levels of radionuclides, and from uncontaminated areas near Kyiv, Ukraine. Counter to expectations, we did not observe a strong DNA damage response in animals exposed to radionuclides, although some signs of oxidative stress were identified. Rather, exposure to environmental radionuclides was associated with upregulation of genes involved in lipid metabolism and fatty acid oxidation in the livers – an apparent shift in energy metabolism. Moreover, using stable isotope analysis, we identified that fur from bank voles inhabiting the CEZ had enriched isotope values of nitrogen: such an increase is consistent with increased fatty acid metabolism, but also could arise from a difference in diet or habitat between the CEZ and elsewhere. In livers and spleens, voles inhabiting the CEZ were characterized by immunosuppression, such as impaired antigen processing, and activation of leukocytes involved in inflammatory responses. In conclusion, exposure to low dose environmental radiation impacts pathways associated with immunity and lipid metabolism, potentially as a stress-induced coping mechanism.
Data from: Use of environmental sites by mule deer: a proxy for relative risk of chronic wasting disease exposure and transmission
Prions that cause chronic wasting disease (CWD) in cervids can remain infective for years outside the host. Infectious cervids shed prions for a long time, consequently depositing prions in frequently used areas. These environmental prions are important in CWD epidemiology. Unfortunately, effective tools for quantifying CWD prions in soil, water, and other environmental sources are not currently available. Our goal was to investigate relative differences in visits by mule deer (Odocoileus hemionus hemionus) to various environmental site types as an indicator of the relative risk of prion contamination and disease transmission. For this, we deployed a system of triggered-by-movement cameras at eight site types in a CWD-endemic area in Saskatchewan, Canada. We first assessed whether the relative differences among site types in the frequency of visits by mule deer of any sex-and-age class, males, and females varied by season and site type. We then assessed whether the rate of behaviors with a high risk of environmental prion transmission (either contamination or acquisition) differed by season and site type. Finally, we assessed whether the intensity of visitation, based on the number of animals per picture, differed by season and site type. We found that grain sources and beds were key attractants for mule deer: (1) The greatest number of pictures with mule deer per camera-day occurred at grain sources across all seasons, except in fawning, when beds were the most visited sites; (2) during pre-rut and early gestation, mule deer visited grain sources at least twice as often as most other sites; (3) females were more likely to visit beds and grain sources, but there was no significant site preferences for males after accounting for season; (4) mule deer were most likely to be pictured contacting the environment at grain sources in early gestation; and (5) beds and grain sources were the most intensively visited sites. We also found that environmental contacts at waterholes were more frequent during spring. We discuss the potential importance of various sites in the transmission of CWD and how their modification could potentially reduce the risk of prion environmental exposure among mule deer.
Data from: Increased transgenerational epigenetic variation, but not predictable epigenetic variants, after environmental exposure in two apomictic dandelion lineages
DNA methylation is one of the mechanisms underlying epigenetic modifications. DNA methylations can be environmentally induced and such induced modifications can at times be transmitted to successive generations. However, it remains speculative how common such environmentally induced transgenerational DNA methylation changes are and if they persist for more than one offspring generation. We exposed multiple accessions of two different apomictic dandelion lineages of the Taraxacum officinale group (Taraxacum alatum and T. hemicyclum) to drought and salicylic acid (SA) treatment. Using methylation-sensitive amplified fragment length polymorphism markers (MS-AFLPs) we screened anonymous methylation changes at CCGG restriction sites throughout the genome after stress treatments and assessed the heritability of induced changes for two subsequent unexposed offspring generations. Irrespective of the initial stress treatment, a clear buildup of heritable DNA methylation variation was observed across three generations, indicating a considerable background rate of heritable epimutations. Less evidence was detected for environmental effects. Drought stress showed some evidence for accession-specific methylation changes, but only in the exposed generation and not in their offspring. By contrast, SA treatment caused an increased rate of methylation change in offspring of treated plants. These changes were seemingly undirected resulting in increased transgenerational epigenetic variation between offspring individuals, but not in predictable epigenetic variants. While the functional consequences of these MS-AFLP-detected DNA methylation changes remain to be demonstrated, our study shows that (1) stress-induced transgenerational DNA methylation modification in dandelions is genotype and context-specific; and (2) inherited environmental DNA methylation effects are mostly undirected and not targeted to specific loci.
Hospital Environmental Exposure
ClinicalTrials.gov study NCT06802367. IPD Sharing: Not stated. Countries: 0. Publications: 13.
Environmental Exposures, Genetics, and Exhaled Nitric Oxide in Pediatric Asthma
ClinicalTrials.gov study NCT00395096. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases
ClinicalTrials.gov study NCT06529913. IPD Sharing: NO. Countries: 1. Publications: 9.
Impact of Environmental Exposure at Home Address on One-year Post-myocardial Infarction Survival
ClinicalTrials.gov study NCT05449912. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Environmental Polymorphisms Registry Health and Exposures Survey
ClinicalTrials.gov study NCT01688986. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Validation of Strasbourg Environmental Exposure Chamber ALYATEC in Mite Allergic Subjects With Asthma
ClinicalTrials.gov study NCT04663880. IPD Sharing: NO. Countries: 1. Publications: 1.
Prevention of Environmental Tobacco Smoke Exposure in Children 0-12 Months Old
ClinicalTrials.gov study NCT00340106. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Core Body Temperature Measurement During Hot and Cold Environmental Exposure
ClinicalTrials.gov study NCT01793337. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of Exposure to Environmental Pollutants on Birth Outcomes in an Israeli Cohort
ClinicalTrials.gov study NCT03084445. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cat Pilot Study - Environmental Exposure Chamber (EEC) vs. Nasal Allergen Challenge (NAC)
ClinicalTrials.gov study NCT02163122. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness of an Air Purifier on Asthmatic and Cat-allergic Subjects in the ALYATEC Environmental Exposure Chamber
ClinicalTrials.gov study NCT06691568. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reduction of Environmental Tobacco Smoke (ETS) Exposure at Home: the BIBE Study
ClinicalTrials.gov study NCT00788996. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy of Air Cleaners in Asthmatics Allergic to Cat in ALYATEC Environmental Exposure Chamber
ClinicalTrials.gov study NCT03928561. IPD Sharing: NO. Countries: 1. Publications: 2.
An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber
ClinicalTrials.gov study NCT00537355. IPD Sharing: NO. Countries: 1. Publications: 1.
A Dose-response Evaluation of the SQ Tree SLIT-tablet Using an Environmental Exposure Chamber
ClinicalTrials.gov study NCT02481856. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.