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1,055
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Dataset results
1,055 results for “FDA”
[Trial of device that is not approved or cleared by the U.S. FDA]
ClinicalTrials.gov study NCT06228144. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Study Of An Investigational Regimen Including FDA Approved HIV Drugs In HIV-Infected Pediatric Subjects
ClinicalTrials.gov study NCT00071760. IPD Sharing: Not stated. Countries: 7. Publications: 1.
Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH Therapies
ClinicalTrials.gov study NCT01266265. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study 302: BLI4900 Versus an FDA-approved Comparator in Adult Subjects Prior to Colonoscopy
ClinicalTrials.gov study NCT04446312. IPD Sharing: NO. Countries: 1. Publications: 1.
[Trial of device that is not approved or cleared by the U.S. FDA]
ClinicalTrials.gov study NCT07186491. IPD Sharing: Not stated. Countries: 0. Publications: 0.
UPLC-MS/MS Method for quantitation of the recently FDA approved combination of vaborbactam and meropenem in human plasma
Open the record for dataset details and reuse information.
US FDA FAERS Drug Adverse Event Dataset Processed as Relational CSV
<p>WARNING: This is an early attempt at processing a large dataset, and I have not yet completely validated the processing scripts or the resulting CSV files.</p> <p>This is a compressed archive of the US FDA FAERS Drug Averse Event database, obtained from open.fda.gov (https://open.fda.gov) and processed with scripts that I wrote (https://github.com/dbuijs/faers2csv) to convert the 100 GB of JSON files into relational CSV that take up approximately 6 GB of space and are suitable for loading into a relational database such as PostgreSQL. </p> <p>This version of the data was processed on January 29, 2016. </p> <p>faerscsv.tar.bz2 expands into a folder called csv, with 4 relational CSV files for each source JSON file.</p> <p>faerstats.tar.bz2 expands into a folder called stats, with a text file for each CSV file containing summary statistics generated by csvstat (Python CSVkit).</p>
Supporting Information for Cholinergic Selectivity of FDA-approved and Metabolite Compounds Examined with Molecular Docking-based Virtual Screening
<p><span>Typical docking configurations, detailed docking and visualization results for representative ligands and proteins. </span></p>
Dataset for Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling"
<p>All FDA labels and extraction sheets to support our paper, Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling".</p>
Dataset for Kuzucan et al., "Approvals for use in populations specifically excluded from trials supporting FDA-approved antibiotics, 1999-2018"
<p>Extraction sheet for Kuzucan et al., "Approvals for use in populations specifically excluded from trials supporting FDA-approved antibiotics, 1999-2018" (citation forthcoming)</p>
Identifying neprilysin-inhibiting FDA approved drugs as possible risk factors for Alzheimer's disease
<p>Although Alzheimer’s disease is the most common type of dementia, unfortunately, safe and effective treatments that could slow the progress of this progressive neurodegenerative disease are still lacking. This amplifies the importance of preventing this disease and, thus, identifying its risk factors. It has already been known that various drugs may increase the risk for Alzheimer’s disease. Here, we searched for approved drugs that may increase this risk through inhibiting neprilysin. Neprilysin is the rate-limiting enzyme in the amyloid beta clearance pathway and is even able to catalyze unphysiologically large amount of amyloid beta. Inhibitors of neprilysin may increase the risk of Alzheimer’s disease and exacerbate its progress via increasing the amounts of the accumulated amyloid beta and its secondary products.</p> <p>In this study, after predicting the blood-brain barrier (BBB) penetration of approved drugs and their metabolites, we used various computational tools to identify potential inhibitors of neprilysin among them. These tools included various structure-based approaches like docking with AutoDockZn, PLANTS, FlexX, Fitted, Molegro, and Flare and rescoring with these scoring functions: Convex-PL, GNINA, JamdaScorer, KORP-PL, RF-Score-VS, Rank Score, dG, VScore. The reliability of these methods was assessed by investigating the correlations of their predictions with experimental measurements. We also used these ligand-based approaches: 2D-QSAR modelling and similarity comparison based on feature trees.</p> <p>These <em>in silico</em> tools suggested that several drugs deserve to be further investigated beacuase of their considerable binding affinity to neprilysin and BBB penetration: aripiprazole, etoricoxib, nabumetone, fentiazac, clorotepine, pitolisant, and chloroquine. Other drugs whose BBB penetration were not predicted to be much high yet their chronic or common use may lead to consequential inhibition of neprilysin can be added to this list, like glyburide, lisinopril, cilazapril, fosinopril, prucalopride, ibersartan, valsartan, and montelukast. Further investigations, including <em>in vitro</em>, animal, and human investigations, can help mitigate the huge and rising societal and economic burden of Alzheimer’s disease globally.</p>
New Tablet Containing Two FDA Approved Anti-HIV Drugs For Antiretroviral Therapy Experienced HIV-1 Infected Subjects
ClinicalTrials.gov study NCT00044577. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Head-to-Head Comparison Study Between Different FDA Registered Allergy Skin Test Applicators
ClinicalTrials.gov study NCT07400718. IPD Sharing: NO. Countries: 1. Publications: 5.
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
ClinicalTrials.gov study NCT02693535. IPD Sharing: Not stated. Countries: 1. Publications: 20.
Metal Ion Release From an FDA-Approved Metal-on-Metal Total Hip Replacement Implant
ClinicalTrials.gov study NCT00962351. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A New Tablet Containing Two FDA-Approved Drugs In HIV-Infected Patients Who Have Not Received Prior Therapy
ClinicalTrials.gov study NCT00053638. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Meta-analysis of 46 FDA Identified Studies on Lipid Markers
ClinicalTrials.gov study NCT03468127. IPD Sharing: NO. Countries: 1. Publications: 1.
A Clinical Trial of Vorinostat (MK0683, SAHA) in Combination With FDA Approved Cancer Drugs in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)(0683-056)
ClinicalTrials.gov study NCT00473889. IPD Sharing: Not stated. Countries: 0. Publications: 1.
FDA Approved Medication to Reduce Binge Eating and/or Purging
ClinicalTrials.gov study NCT02553824. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of the Efficacy and Safety of the Combination of Two FDA Approved Oral Medications, Nebivolol and Valsartan for Treatment of Stage 1 or 2 Hypertension
ClinicalTrials.gov study NCT01508026. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.