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193 results for “Heme”
The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart
ClinicalTrials.gov study NCT02314780. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Thiol catalyzed NO-ferro-heme signaling
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Data from: An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis
<p>Energy-coupling factor type (ECF-transporters) represent trace nutrient acquisition systems. Substrate binding components of ECF-transporters are membrane proteins with extraordinary affinity, allowing them to scavenge trace amounts of ligand. A number of molecules have been described as substrates of ECF-transporters, but an involvement in iron-acquisition is unknown. Host-induced iron limitation during infection represents an effective mechanism to limit bacterial proliferation. We identified the iron-regulated ECF-transporter Lha in the opportunistic bacterial pathogen <i>Staphylococcus lugdunensis</i> and show that the transporter is specific for heme. The recombinant substrate-specific subunit LhaS accepted heme from diverse host-derived hemoproteins. Using isogenic mutants and recombinant expression of Lha, we demonstrate that its function is independent of the canonical heme acquisition system Isd and allows proliferation on human cells as sources of nutrient iron. Our findings reveal a unique strategy of nutritional heme acquisition and provide the first example of an ECF-transporter involved in overcoming host-induced nutritional limitation.</p>
A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria- MD simulation files
<p>This folder contains the first and last frame of MD simulations conducted in this study. </p> <p>The Free-MD folder contains unconstrained MD simulation files for Dri1 (WT) and its variants (H16A, H21A, H79A, H16A:H21A, H16A:H79A, H21A:H79A and H79A:R90A)</p> <p>The SAXS-dirven MD folder contains SAXS data constrained MD simulation files for Dri1 WT, Dri1 H21A and Dri H79A:R90A with 3 different starting structures for variants. </p>
Heme oxygenase pfam14518 sequence similarity network
<p>Sequence similarity network generated from pfam14518 using the EFI-GNT webtool. Each node is representative of sequences that are 80% identical. </p>
Absorption of Heme and Non-Heme Iron in Pregnant and Non-pregnant Women and Mechanisms of Fetal Iron Transfer
ClinicalTrials.gov study NCT01019096. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Fludarabine and Intermediate-dose TBI Followed by PTCy in Patients Undergoing Allo Transplant for Heme Malignancies
ClinicalTrials.gov study NCT07214688. IPD Sharing: NO. Countries: 1. Publications: 14.
Monocytic Expression of Heme Oxidase-1 (HO-1) in Sickle Cell Patients and Correlation With the Humoral Immune Response to Vaccine and With Allo-immunization.
ClinicalTrials.gov study NCT03111589. IPD Sharing: NO. Countries: 1. Publications: 13.
Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection
ClinicalTrials.gov study NCT00842205. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Non-Heme Iron Load Quantification in the Brain - MRI of Patients With Stroke
ClinicalTrials.gov study NCT01829386. IPD Sharing: NO. Countries: 1. Publications: 7.
Heme Arginate in Functional Magnetic Resonance Imaging (fMRI)
ClinicalTrials.gov study NCT01461512. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy
ClinicalTrials.gov study NCT06457958. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis
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Dataset related to article: "Heme catabolism by tumor-associated macrophages controls metastasis formation"
<p>This record contains raw data related to article "Heme catabolism by tumor-associated macrophages controls metastasis formation"</p> <p> </p> <p>Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct subset of TAMs (F4/80<sup>hi</sup>CD115<sup>hi</sup>C3aR<sup>hi</sup>CD88<sup>hi</sup>), endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1 (HO-1), plays a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition. This population originates from F4/80<sup>+</sup>HO-1<sup>+</sup> bone marrow (BM) precursors, accumulates in the blood of tumor bearers and preferentially localizes at the invasive margin through a mechanism dependent on the activation of Nrf2 and coordinated by the NF-κB1-CSF1R-C3aR axis. Inhibition of F4/80<sup>+</sup>HO-1<sup>+</sup> TAM recruitment or myeloid-specific deletion of HO-1 blocks metastasis formation and improves anticancer immunotherapy. Relative expression of HO-1 in peripheral monocyte subsets, as well as in tumor lesions, discriminates survival among metastatic melanoma patients. Overall, these results identify a distinct cancer-induced HO-1<sup>+</sup> myeloid subgroup as a new antimetastatic target and prognostic blood marker.</p>
HEME Home Transfusion Program
ClinicalTrials.gov study NCT06487247. IPD Sharing: YES. Countries: 1. Publications: 0.
MT2017-45: CAR-T Cell Therapy for Heme Malignancies
ClinicalTrials.gov study NCT03642626. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adoptive TReg Cell for Suppression of aGVHD After UCB HSCT for Heme Malignancies
ClinicalTrials.gov study NCT02991898. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Home Transfusion for HEME
ClinicalTrials.gov study NCT05509439. IPD Sharing: YES. Countries: 1. Publications: 0.
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
ClinicalTrials.gov study NCT05735717. IPD Sharing: NO. Countries: 1. Publications: 0.
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
ClinicalTrials.gov study NCT04195438. IPD Sharing: YES. Countries: 1. Publications: 0.
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International Brain Laboratory public data
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OpenNeuro
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