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Identification of a Pool of miRNA to Improve Early Management of Perinatal Asphyxia and Hypoxic Ischemic Encephalopathy

ClinicalTrials.gov study NCT05986994. IPD Sharing: NO. Countries: 1. Publications: 12.

Predictive Value of aEEG and Cerebral Oxygenation on Neurological Outcomes in Newborns With Mild Hypoxic-Ischemic Encephalopathy

ClinicalTrials.gov study NCT07393620. IPD Sharing: NO. Countries: 1. Publications: 7.

Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy

ClinicalTrials.gov study NCT05514340. IPD Sharing: NO. Countries: 1. Publications: 4.

The Clinical Trial of CL2020 Cells for Neonatal Hypoxic Ischemic Encephalopathy

ClinicalTrials.gov study NCT04261335. IPD Sharing: NO. Countries: 1. Publications: 2.

Severity of Hypoxic Ischemic Encephalopathy and Neurological Pupil Index in Neonates

ClinicalTrials.gov study NCT07024771. IPD Sharing: NO. Countries: 1. Publications: 12.

Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy

ClinicalTrials.gov study NCT01732146. IPD Sharing: Not stated. Countries: 1. Publications: 2.

Continuous Versus Bolus Feeding in Neonates With Hypoxic Ischemic Encephalopathy

ClinicalTrials.gov study NCT06447155. IPD Sharing: NO. Countries: 1. Publications: 5.

Hypoxic-Ischemic Encephalopathy Therapy Optimization in Neonates for Better Neuroprotection With Inhalative CO2

ClinicalTrials.gov study NCT02700854. IPD Sharing: NO. Countries: 1. Publications: 4.

CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy

ClinicalTrials.gov study NCT00383305. IPD Sharing: Not stated. Countries: 4. Publications: 6.

Role of Umbilical Cord Milking in the Management of Hypoxic-ischemic Encephalopathy in Neonates

ClinicalTrials.gov study NCT03123081. IPD Sharing: NO. Countries: 1. Publications: 9.

Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants

ClinicalTrials.gov study NCT03640494. IPD Sharing: NO. Countries: 1. Publications: 2.

Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia

ClinicalTrials.gov study NCT01241019. IPD Sharing: Not stated. Countries: 1. Publications: 4.

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Data from: Observational study of hemostatic dysfunction and bleeding in neonates with hypoxic-ischemic encephalopathy

Objective: Evaluate the relationship between initial haemostatic parameters and the frequency and severity of bleeding in neonates with hypoxic–ischaemic encephalopathy (HIE). Design: Retrospective observational cohort study. Setting: 2 academically affiliated level III neonatal intensive care units in Atlanta, Georgia. Participants: 98 neonates with moderate-to-severe HIE who underwent haemostatic testing within 12 hours of birth and were born from 1 January 2008 to 31 December 2013. Primary and secondary outcome measures: Initial haemostatic dysfunction was defined as one or more of the following: prothrombin time (PT) ≥18 s, platelet count <100×103/μL or fibrinogen <150 mg/dL. Bleeding assessed using the Neonatal Bleeding Assessment Tool and graded according to the WHO bleeding scale. The robust Poisson regression was used to evaluate the independent association between components of initial haemostatic dysfunction and bleeding. Results: Among the 98 neonates evaluated, the prevalence of initial haemostatic dysfunction was 69% (95% CI 59% to 78%). 27 neonates (28%; 95% CI 19% to 38%) had abnormal bleeding events and 56 (57%) received at least 1 blood product transfusion. 3 neonates died from bleeding complications. The most common products transfused were fresh-frozen plasma (71%), followed by packed red blood cells (24%) and platelets (21%). In multivariable analysis, fibrinogen <150 mg/dL (adjusted relative risk 2.41, 95% CI 1.09 to 5.36) and platelet count <100×103/μL (adjusted relative risk 2.59, 95% CI 1.30 to 5.16), but not initial PT, were associated with an increased risk of bleeding. The most severe bleeding occurred in neonates with a fibrinogen <150 mg/dL. Conclusions: Among neonates with moderate-to-severe HIE, haemostatic dysfunction is prevalent and associated with an increased risk of bleeding and high transfusion burden. Further studies are needed to determine the appropriate transfusion approaches in this population to prevent bleeding.

MRI Thermal Imaging of Infants Undergoing Cooling for Hypoxic Ischemic Encephalopathy(HIE)

ClinicalTrials.gov study NCT01128673. IPD Sharing: Not stated. Countries: 1. Publications: 0.

Neonatal Hypoxic Ischemic Encephalopathy:Early Diagnosis and Management of Comorbidities

ClinicalTrials.gov study NCT03550612. IPD Sharing: UNDECIDED. Countries: 0. Publications: 7.

Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy

ClinicalTrials.gov study NCT03163589. IPD Sharing: Not stated. Countries: 0. Publications: 9.

Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy

ClinicalTrials.gov study NCT01765218. IPD Sharing: Not stated. Countries: 1. Publications: 0.

A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy

ClinicalTrials.gov study NCT04063215. IPD Sharing: Not stated. Countries: 1. Publications: 0.

Antenatal and Intrapartum Risk Factors Associated With Neonatal Hypoxic Ischemic Encephalopathy

ClinicalTrials.gov study NCT04364932. IPD Sharing: Not stated. Countries: 0. Publications: 4.

Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy

ClinicalTrials.gov study NCT05130528. IPD Sharing: NO. Countries: 1. Publications: 0.