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54 results for “Inertia”
Ageing as early-life inertia: disentangling life-history trade-offs along a lifetime of an individual
<p>The theory that ageing evolves because of competitive resource allocation between the soma and the germline has been challenged by studies showing that somatic maintenance can be improved without impairing reproduction. However, it has been suggested that cost-free improvement in somatic maintenance is possible only under a narrow range of benign conditions. Here we show that experimental downregulation of insulin/IGF-1 signalling (IIS) in C. elegans nematodes, a robustly reproducible lifespan and healthspan-extending treatment, reduces fitness in a complex variable environment when initiated during development but does not reduce fitness when initiated in adulthood. Thus, our results show that the costs and benefits of reduced IIS can be uncoupled when organisms inhabit variable environments, and, therefore, do not provide support for the resource allocation theory. Our findings support the theory that the force of natural selection on gene expression in evolutionarily conserved signalling pathways that shape life-history traits declines after the onset of reproduction resulting in organismal senescence.</p>
Delayed-release Bedtime Caffeine and Sleep Inertia Symptoms Immediately Upon Awakening
ClinicalTrials.gov study NCT04975360. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Reducing Clinical Inertia in Diabetes Care
ClinicalTrials.gov study NCT00272402. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Sleep Inertia and Functional Connectivity
ClinicalTrials.gov study NCT03058159. IPD Sharing: NO. Countries: 1. Publications: 1.
Real-world Evaluation of GLP-1 Receptor Agonists (GLP-1RA) on Efficacy and Persistence, Adherence and Therapeutic Inertia Among Type 2 Diabetes Adults With Obesity
ClinicalTrials.gov study NCT05535322. IPD Sharing: UNDECIDED. Countries: 1. Publications: 18.
Effects of Water Inertia Load Training on Lower Limb Joint Moments, Gait, and Balance in Elderly Women
ClinicalTrials.gov study NCT06705946. IPD Sharing: YES. Countries: 1. Publications: 10.
Ageing as early-life inertia: disentangling life-history trade-offs along a lifetime of an individual
Open the record for dataset details and reuse information.
Data from: A consensus study to define appropriate inaction and inappropriate inertia in the management of hypertensive patients in primary care
Objectives. To elaborate and validate operational definitions for appropriate inaction and for inappropriate inertia in the management of hypertensive patients in primary care. Design. A two-step approach was used to reach a definition consensus. First, nominal groups provided practice-based information on the two concepts. Second, a Delphi procedure was used to modify and validate the two definitions created from the nominal groups results. Participants. 14 French practicing GPs participated in each of the two nominal groups, held in two different areas in France. For the Delphi procedure, 30 academics, international experts in the field, were contacted; 20 agreed to participate, and 19 completed the procedure. Results. Inappropriate inertia was defined as: to not initiate or intensify an antihypertensive treatment for a patient who is not at the blood pressure goals defined for this patient in the guidelines when all following conditions are fulfilled: (1) elevated blood pressure has been confirmed by self-measurement or ambulatory BP monitoring, (2) there is no legitimate doubt on the reliability of the measurements, (3) there is no observance issue regarding pharmacological treatment, (4) there is no specific iatrogenic risk (which alters the risk-benefit balance of treatment for this patient), in particular orthostatic hypotension in the elderly, (5) there is no other medical priority more important and more urgent, (6) access to treatment is not difficult. Appropriate inaction was defined as the exact mirror, i.e. when at least one of the above conditions is not met. Conclusion. Definitions of appropriate inaction and inappropriate inertia in the management of hypertensive patients have been established from empirical practice-based data and validated by an international panel of academics as useful for practice and research.
Data from: Falling with style: bats perform complex aerial rotations by adjusting wing inertia
The remarkable maneuverability of flying animals results from precise movements of their highly specialized wings. Bats have evolved an impressive capacity to control their flight, in large part due to their ability to modulate wing shape, area, and angle of attack through many independently controlled joints. Bat wings, however, also contain many bones and relatively large muscles, and thus the ratio of bats' wing mass to their body mass is larger than it is for all other extant flyers. Although the inertia in bat wings would typically be associated with decreased aerial maneuverability, we show that bat maneuvers challenge this notion. We use a model-based tracking algorithm to measure the wing and body kinematics of bats performing complex aerial rotations. Using a minimal model of a bat with only six degrees of kinematic freedom, we show that bats can perform body rolls by selectively retracting one wing during the flapping cycle. We also show that this maneuver does not rely on aerodynamic forces, and furthermore that a fruit fly, with nearly massless wings, would not exhibit this effect. Similar results are shown for a pitching maneuver. Finally, we combine high-resolution kinematics of wing and body movements during landing and falling maneuvers with a 52-degree-of-freedom dynamical model of a bat to show that modulation of wing inertia plays the dominant role in reorienting the bat during landing and falling maneuvers, with minimal contribution from aerodynamic forces. Bats can, therefore, use their wings as multifunctional organs, capable of sophisticated aerodynamic and inertial dynamics not previously observed in other flying animals. This may also have implications for the control of aerial robotic vehicles.
Data from: Muscle shortening velocity depends on tissue inertia and level of activation during submaximal contractions
In order to perform external work, muscles must do additional internal work to deform their tissue, and in particular, to overcome the inertia due to their internal mass. However, the contribution of the internal mass within a muscle to the mechanical output of that muscle has only rarely been studied. Here, we use a dynamic, multi-element Hill-type muscle model to examine the effects of the inertial mass within muscle on its contractile performance. We find that the maximum strain-rate of muscle is slower for lower activations and larger muscle sizes. As muscle size increases, the ability of the muscle to overcome its inertial load will decrease, as muscle tension is proportional to cross-sectional area and inertial load is proportional to mass. Thus, muscles that are larger in size will have a higher inertial cost to contraction. Similarly, when muscle size and inertial load are held constant, decreasing muscle activation will increase inertial cost to contraction by reducing muscle tension. These results show that inertial loads within muscle contribute to a slowing of muscle contractile velocities (strain-rates), particularly at the submaximal activations that are typical during animal locomotion.
Generalized Rayleigh-Taylor Instability: Ion Inertia, Acceleration Forces, and E Region Drivers
<p>electron density and growth rate data files</p>
Increased inertia triggers linear responses in motor cortices during large-extent movements – an fNIRS study
<pre>Representative video footage of actual experimental scenarios. </pre>
Data from: Falling with style: bats perform complex aerial rotations by adjusting wing inertia
Open the record for dataset details and reuse information.
Data from: Muscle shortening velocity depends on tissue inertia and level of activation during submaximal contractions
Open the record for dataset details and reuse information.
Data from: A consensus study to define appropriate inaction and inappropriate inertia in the management of hypertensive patients in primary care
Open the record for dataset details and reuse information.
Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia [RNA-seq]
GEO Series GSE178306. Homo sapiens. 108 samples. Type: Expression profiling by high throughput sequencing.
Study of Sleep Inertia in Major Depressive Disorder by the Psychomotor Vigilance Task
ClinicalTrials.gov study NCT06732284. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Overcoming Therapeutic Inertia Among Adults Recently Diagnosed With Type 2 Diabetes
ClinicalTrials.gov study NCT05566847. IPD Sharing: NO. Countries: 1. Publications: 0.
Approaches to Reduce Clinical Inertia in Hypertension in the Dominican Republic
ClinicalTrials.gov study NCT03954951. IPD Sharing: NO. Countries: 1. Publications: 0.
Neuronal Inertia in Propofol Anesthesia
ClinicalTrials.gov study NCT01962285. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.