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428 results for “Malformations”
Fig. 1 in International Journal for Parasitology: Parasites and Wildlife Outbreak of parasite-induced limb malformations in a declining amphibian species in Colorado
Fig. 1. (A) Spring Brook North (SBN) Pond is located in southern Boulder County near Eldorado Springs, Colorado, USA. (B) Image of the pond in spring. (C) Northern leopard frogs (Rana pipiens) use the pond as breeding habitat (image copyright David Herasimtschuk).
Fig. 2 in International Journal for Parasitology: Parasites and Wildlife Outbreak of parasite-induced limb malformations in a declining amphibian species in Colorado
Fig. 2. Limb malformations in leopard frogs from this study include (A–D) skin webbings, which can affect one (A–B) or both (C–D) hind limbs; (E–H) bony triangles, which entail a triangular folding in a longbone and an associated shortening of the limb; and (H–K) extra limbs, feet, and digits, which were typically ventral. Frog in (H) exhibits a double bony triangle and severe truncation in the limb with a duplicated foot. Many animals exhibited multiple malformations and severe structural limb deformities, such as (L).
Surgical Outcomes in Chiari 1 and Chiari 1.5 Malformation (pediatric cohort)
<p>Anonymized dataset of the cohort of patients for the paper:</p> <p><span>Surgical Outcomes in Chiari 1 and Chiari 1.5 Malformation Treated by Posterior Fossa Reconstruction: A Comprehensive Analysis of 110 Pediatric Cases </span><span>and Literature Review.</span></p>
Supplementary material to: Angioarchitecture and hemodynamics of microvascular arterio-venous malformations
<p>Supplementary material (code and raw data) to the manuscript "Angioarchitecture and hemodynamics of microvascular arterio-venous malformations" by Frey et al., under consideration for publication in PLOS One</p>
Whole-genome sequencing reveals contribution of rare and common variation to structural kidney and urinary tract malformations
<p>Supplementary tables detailing analysis of whole-genome sequencing data from 992 patients with congenital anomalies of the kidneys and urinary tract (CAKUT). </p>
Figure 1 in Ocular tentacle malformation in Deroceras reticulatum (Mollusca: Gastropoda: Agriolimacidae)
Figure 1. Deroceras reticulatum in life. Right side view (A); dorsal view (B); detail of the ocular tentacles (C-D); left side view (E). Scale bar: 2 mm.
Phase-contrast MRI data of 18 Chiari-I malformation patients and 21 controls
<p>We collected phase-contrast MRI data (5-mm midline sagittal section, rostro-caudal direction) and obtained average velocity in certain Regions-0f-Interest (ROIs). The measured ROIs are cerebellar tonsil, ventral spinal subarachnoid space, dorsal spinal subarachnoid space, upper portion of syrinxes, upper cervical cord, and medulla. Data obtained from 18 Chiari-I patients (preoperative and postoperative) and 21 controls are included. Because the preoperative MRI data was missing in one patient, the preoperative studies included 17 MRI sessions. The unit of the data is cm/sec. The data are synchronized with pre-processing so that the rise of the caudal CSF movement be placed at the center of the cardiac cycle.</p>
Survival and malformations, swimming performance and tadpole traits
<p>Targeted gene flow (TGF) could bolster the adaptive potential of isolated populations threatened by climate change, but could also lead to outbreeding depression. Here, we explore these possibilities by creating mixed- and within-population crosses in a terrestrial-breeding frog species threatened by a drying climate. We reared embryos on wet and dry soils and quantified fitness-related traits upon hatching. TGF produced mixed outcomes in hybrids which depended on crossing direction (origin of gametes from each sex). North-south crosses led to low embryonic survival if eggs were of a southern origin, and high malformation rates when eggs were from a northern population. Conversely, east-west crosses led to one instance of hybrid vigour, evident by increased fitness and desiccation tolerance of hybrid offspring relative to offspring produced from within-population crosses. These contrasting results highlight the need to experimentally evaluate the outcomes of TGF for focal species across generations prior to implementing management actions.<b> </b></p>
Study Evaluating the Safety and Efficacy of PTX-022 (QTORIN Sirolimus) in the Treatment of Microcystic Lymphatic Malformations
ClinicalTrials.gov study NCT05050149. IPD Sharing: NO. Countries: 1. Publications: 1.
Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)
ClinicalTrials.gov study NCT00670956. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia
ClinicalTrials.gov study NCT02669836. IPD Sharing: Not stated. Countries: 1. Publications: 38.
A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations
ClinicalTrials.gov study NCT01290484. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fetal Treatment of Galenic Malformations
ClinicalTrials.gov study NCT04434729. IPD Sharing: NO. Countries: 1. Publications: 3.
Sildenafil for the Treatment of Lymphatic Malformations
ClinicalTrials.gov study NCT02335242. IPD Sharing: NO. Countries: 1. Publications: 19.
Phase-contrast MRI data of 18 Chiari-I malformation patients and 21 controls
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Survival and malformations, swimming performance and tadpole traits
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Columbia Suicide Severity Rating Scale Screen scores in adults with Chiari malformation Type 1
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Raw images from: Genetic inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish
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Low-dose antibiotic prophylaxis has no significant impact on the stability of the intestinal microbiome in children with urogenital tract malformations under 1 year of age.
<p>Raw data for the evaluation of the stool microbiome in children under antibiotic prophylaxis vs. controls.</p>
Modifiable cardiovascular risk factors in patients with sporadic cerebral cavernous malformations: obesity matters
Objective <p>To assess the influence of modifiable cardiovascular risk factors on hemorrhage risk of sporadic cerebral cavernous malformations (CCMs).</p> Methods <p>From 1219 consecutive CCM patients (2003-2018), adult subjects with sporadic CCM and complete MRI were included. We evaluated presence of intracerebral hemorrhage (ICH) as mode of presentation, occurrence of ICH during follow-up and risk factors arterial hypertension, diabetes mellitus, hyperlipidemia, nicotine abuse, and obesity (BMI>30kg/m²). Impact of risk factors on ICH at presentation was calculated using univariate and multivariate logistic regression with age- and sex-adjustment. We performed Kaplan Meier and Cox regression to analyze cumulative 5-year-risk for (re-)bleeding. </p> Results <p>We included 682 CCM patients. The univariate logistic regression showed a significant relationship (OR=1.938, 95% CI: (1.120–3.353), p=0.018) between obesity and ICH as mode of presentation. Multivariate adjusted logistic regression confirmed significant correlation with OR=1.902 (95% CI: 1.024–3.532, p=0.042). Cox regression did not identify predictors for occurrence of (re-)hemorrhage (p>0.05; Hazard ratios: arterial hypertension 1.112 (95% CI: 0.622–1.990), diabetes 0.850 (95% CI: 0.208–3.482), hyperlipidemia 0.719 (95% CI: 0.261–1.981), nicotine abuse 1.123 (95% CI: 0.591–2.134), and obesity 0.928 (95% CI: 0.416–2.070)). </p> Conclusions <p>This study provides evidence that obesity may be a risk factor for CCM hemorrhage. It was significantly associated with ICH as mode of presentation. Other risk factors (arterial hypertension, diabetes mellitus, hyperlipidemia and current nicotine abuse) showed no such effect. None of the factors showed to be independent predictors for cumulative 5-year-risk of (re-)bleeding. </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.