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2,435 results for “Metastasis”
A 3D multi-cellular tissue model of the human omentum to study mechanisms of ovarian cancer metastasis
<p>Here, the design of 3D multi-cellular tissue model of the human omentum is presented to study mechanisms of ovarian cancer metastasis.</p>
SCLC brain metastasis
<p>Brain metastasis is a major cause of morbidity and mortality in cancer patients. Here we investigated mechanisms allowing small-cell lung cancer (SCLC) cells to grow in the brain. We show that SCLC cells undergo a cell state transition towards neuronal differentiation during tumor progression and metastasis, and that this neuronal mimicry is critical for SCLC growth in the brain. </p>
Radiomics in hepatic metastasis by colorectal cancer
<p>We uploaded the images of the manuscript Granata V, Fusco R, Barretta ML, Picone C, Avallone A, Belli A, Patrone R, Ferrante M, Cozzi D, Grassi R, Grassi R, Izzo F, Petrillo A. Radiomics in hepatic metastasis by colorectal cancer. Infect Agent Cancer. 2021 Jun 2;16(1):39. doi: 10.1186/s13027-021-00379-y. PMID: 34078424; PMCID: PMC8173908.</p>
Predictive modelling of brain metastasis risk and non-invasive biomarker detection using DNA methylation signatures
<p>Methylated cell-free DNA was sequenced for 123 BM plasma and compared to plasma methylomes from 107 gliomas, central nervous system (CNS) lymphomas (CNSL), and non-CNS tumor controls. Plasma methylome-based classifiers of BM from other entities were built in fifty 80% discovery set iterations of 92/123 BM samples. External publicly-available tissue methylation data on 442 LUAD, 85 BM, and 146 glioma/CNSL/control samples were acquired for validation and the remaining 31/123 BM plasma samples were used for additional validation.</p>
Hepatocellular carcinoma (HCC) Tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) Tumor microenvironment.
<p><strong>Background and purpose:</strong> While HCC is an inflammation-associated cancer, CRLM develop on permissive healthy liver microenvironment. To evaluate the immune aspects of these two different environments, peripheral blood-(PB), peritumoral-(PT) and tumoral tissues-(TT) from HCC and CRLM patients were evaluated.</p> <p><strong>Methods:</strong> 40 HCC and 34 CRLM were enrolled and freshly TT, PT and PB were collected at the surgery. PB-, PT- and TT-derived CD4<sup>+</sup>CD25<sup>+ </sup>Tregs, M/PMN-MDSC and PB-derived CD4<sup>+</sup>CD25<sup>− </sup>Teffector cells (Teffs) were isolated and characterized. Tregs function was also evaluated in the presence of the CXCR4 inhibitor, Peptide-R29, AMD3100 or anti-PD1. RNA was extracted from PB/PT/TT-tissues and tested for FOXP3, CXCL12, CXCR4, CCL5, IL-15, CXCL5, Arg-1, N-cad, Vim, CXCL8, TGFβ and VEGF-A expression.</p> <p><strong>Results:</strong> In HCC/CRLM-PB higher number of functional Tregs, CD4<sup>+</sup>CD25<sup>hi</sup>FOXP3<sup>+</sup> were detected, although PB-HCC Tregs exert a more suppressive function as compared to CRLM-Tregs. In HCC/CRLM-TT Tregs were highly represented with Activated/ENTPD-1<sup>+</sup>Tregs prevalent in HCC. As compared to CRLM, HCC overexpressed CXCR4 and N-cadherin/Vimentin in a contest rich of arginase and CCL5. Monocytic-MDSCs were highly represented in HCC/CRLM while high Polymorphonuclear-MDSCs were detected only in HCC. Interestingly, CXCR4-PB-Tregs function was impaired in HCC/CRLM by the CXCR4 inhibitor R29.</p> <p><strong>Conclusion:</strong> In HCC and CRLM, peripheral blood, peritumoral and tumoral tissues-Tregs are highly represented and functional. Nevertheless, HCC display a more immunosuppressive TME due to Tregs, MDSCs, intrinsic tumor features (CXCR4, CCL5, arginase) and the contest in which it develops. As CXCR4 is overexpressed in HCC/CRLM tumor/TME cells, CXCR4 inhibitors may be considered for double hits therapy in liver cancer patients.</p>
Supplementary Figure MiR-497-5p inhibits metastasis in cervical cancer
<p>Supplementary Figure A. Expression of apoptosis-related proteins, cleaved caspase 3 and cleaved caspase 9, was assayed by WB</p> <p>Supplementary Figure B. Cell migration and invasion abilities were assayed through transwell assay (Mann-Whitney test)</p> <p>Supplementary Figure C. Changes in expression of EMT-related proteins were assayed by WB (Mann-Whitney test). *<em>p</em><0.050 representing statistically significant.</p>
Single-Cell Mapping Reveals Several Immune Subsets Associated with Liver Metastasis of Pancreatic Ductal Adenocarcinoma
<p>Identifying a metastasis-correlated immune cell composition within the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) will help to develop promising and innovative therapeutic strategies. Twenty-six samples from 11 patients (including 11 primary tumor tissues, 10 blood, and 5 lymph nodes) with different stages were used to develop a multiscale immune profile. High-dimensional single-cell analysis with mass cytometry was performed to search for metastasis-correlated immune changes in the microenvironment.</p> <p>The details about the files uploaded are as follows:</p> <p>1. panelA_Blood.zip includes 10 .fcs files from blood samples in Panel A;</p> <p>2. panelA_LN.zip includes 5 .fcs files from lymph node samples in Panel A;</p> <p>3. panelA_Tumor.zip includes 11 .fcs files from tumor tissue samples in Panel A;</p> <p>4. panelB_Tumor.zip includes 11 .fcs files from tumor tissue samples in Panel B;</p> <p>5. panel_metadata.xlsx describes marker used in Panel A and B;</p> <p>6. sample_metadata.xlsx describes detailed sample information.</p>
The Prognostic Value of COX-2 in Predicting Metastasis of Patients with Colorectal Cancer: A systematic review and meta analysis.
<p>The Prognostic Value of COX-2 in Predicting Metastasis of Patients with Colorectal Cancer: A systematic review and meta analysis.</p>
Study of BO-112 With Pembrolizumab for Colorectal or Gastric/GEJ Cancer With Liver Metastasis
ClinicalTrials.gov study NCT04508140. IPD Sharing: NO. Countries: 3. Publications: 1.
Sintilimab Plus Bevacizumab and Chemotherapy in MSS/pMMR Colorectal With no Liver Metastasis
ClinicalTrials.gov study NCT06973343. IPD Sharing: NO. Countries: 1. Publications: 1.
RV001V, a RhoC Anticancer Vaccine, Against Metastasis From Solid Tumours
ClinicalTrials.gov study NCT03199872. IPD Sharing: NO. Countries: 1. Publications: 1.
A Deep Learning Model for Diagnosing Lymph Node Metastasis in Nasopharyngeal Carcinoma(NPC)
ClinicalTrials.gov study NCT06829147. IPD Sharing: NO. Countries: 1. Publications: 24.
EPA for Metastasis Trial 2
ClinicalTrials.gov study NCT03428477. IPD Sharing: YES. Countries: 1. Publications: 1.
Validation of FACBC for Detection of Metastasis Among High-risk Prostate Cancer Patients With Presumed Localized Disease
ClinicalTrials.gov study NCT03081884. IPD Sharing: NO. Countries: 1. Publications: 1.
Validation of a Prognostic Method for Assessing the Risk of Distant Metastasis in Early-stage Breast Cancer
ClinicalTrials.gov study NCT07372261. IPD Sharing: YES. Countries: 1. Publications: 1.
Prognostic Impact of Increased Lymph Node Yield in Colorectal Cancer Patients With Synchronous Distant Metastasis: a Population-based Study of the US Database and a Chinese Registry
ClinicalTrials.gov study NCT05550701. IPD Sharing: NO. Countries: 1. Publications: 3.
Atezolizumab in Combination With Carboplatin Plus Pemetrexed in Chemotherapy-naïve Patients With Asymptomatic Brain Metastasis
ClinicalTrials.gov study NCT03526900. IPD Sharing: NO. Countries: 1. Publications: 1.
LC Bead Embolization Agent With Doxorubicin in the Treatment Liver Metastasis From Melanoma
ClinicalTrials.gov study NCT01010984. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of Alpharadin With Docetaxel in Patients With Bone Metastasis From Castration-Resistant Prostate Cancer (CRPC)
ClinicalTrials.gov study NCT01106352. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy
ClinicalTrials.gov study NCT02609828. IPD Sharing: YES. Countries: 16. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.