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243 results for “Mitochondrial Dysfunction”
Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity
ClinicalTrials.gov study NCT02490527. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
ClinicalTrials.gov study NCT00541827. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
ClinicalTrials.gov study NCT05872139. IPD Sharing: NO. Countries: 1. Publications: 0.
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy
ClinicalTrials.gov study NCT01143467. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
ClinicalTrials.gov study NCT04449198. IPD Sharing: Not stated. Countries: 1. Publications: 1.
In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue.
ClinicalTrials.gov study NCT05753228. IPD Sharing: NO. Countries: 1. Publications: 8.
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis
ClinicalTrials.gov study NCT04513002. IPD Sharing: NO. Countries: 1. Publications: 18.
Mitochondrial Dysfunction in Autism Spectrum Disorder
ClinicalTrials.gov study NCT02000284. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Role of Mitochondrial Dysfunction in the Occurrence of Acute Kidney Injury (AKI) in Postoperative Cardiac Surgery
ClinicalTrials.gov study NCT04125069. IPD Sharing: NO. Countries: 1. Publications: 11.
Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance
ClinicalTrials.gov study NCT03052595. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans
ClinicalTrials.gov study NCT04851288. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Treatment of Mitochondrial Dysfunction in Rett Syndrome With Triheptanoin
ClinicalTrials.gov study NCT02696044. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance
ClinicalTrials.gov study NCT06080594. IPD Sharing: NO. Countries: 1. Publications: 17.
Control of Renal Oxygen Consumption, Mitochondrial Dysfunction, and Insulin Resistance
ClinicalTrials.gov study NCT04074668. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Data from: Mitochondrial dysfunction and infection generate immunity-fecundity tradeoffs in Drosophila
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Data from: Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant ROS production
Women with polycystic ovary syndrome (PCOS) are at increased risk of miscarriage, which often accompanies the hyperandrogenism and insulin resistance seen in these patients. However, neither the combinatorial interaction between these two PCOS-related etiological factors nor the mechanisms of their actions in the uterus during pregnancy are well understood. We hypothesised that hyperandrogensim and insulin resistance exert a causative role in miscarriage by inducing defects in uterine function that are accompanied by mitochondrial-mediated oxidative stress, inflammation and perturbed gene expression. Here we tested this hypothesis by studying the metabolic, endocrine and uterine abnormalities in pregnant rats after exposure to daily injection of 5α-dihydrotestosterone (DHT, 1.66 mg/kg body weight/day) and/or insulin (6.0 IU/day) from gestational day 7.5 to 13.5. We showed that while DHT-exposed and insulin-exposed pregnant rats presented impaired insulin sensitivity, DHT+insulin-exposed pregnant rats exhibited hyperandrogenism and peripheral insulin resistance, which mirrors pregnant PCOS patients. Compared to controls, hyperandrogenism and insulin resistance in the dam was associated with alterations in uterine morphology and aberrant expression of genes responsible for decidualization (Prl8a2, Fxyd2, and Mt1g), placentation (Fcgr3 and Tpbpa), angiogenesis (Flt1, Angpt1, Angpt2, Ho1, Ccl2, Ccl5, Cxcl9, and Cxcl10) and insulin signaling (Akt, Gsk3 and Gluts). Moreover, we observed changes in uterine mitochondrial function and homeostasis (i.e. mitochondrial DNA copy number and the expression of genes responsible for mitochondrial fusion, fission, biogenesis, and mitophagy) and suppression of both oxidative and antioxidative defenses (i.e. reactive oxygen species, Nrf2 signaling, and interactive networks of antioxidative stress responses) in response to the hyperandrogenism and insulin resistance. These findings demonstrate that hyperandrogenism and insulin resistance induce mitochondria-mediated damage and a resulting imbalance between oxidative and antioxidative stress responses in the gravid uterus.
supplementary materials of NMN supplement ameliorates psoriasis-associated inflammation, oxidative stress and mitochondrial dysfunction by activating SIRT1 pathway
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Evaluating Mitochondrial Dysfunction in Patients With Neurofibromatosis Type 1
ClinicalTrials.gov study NCT05912400. IPD Sharing: NO. Countries: 1. Publications: 0.
Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction
ClinicalTrials.gov study NCT06433427. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Mitochondrial dysfUnction: a Key Player in Doxorubicin-induced Skeletal and Cardiac muscLE Damage
ClinicalTrials.gov study NCT05731375. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.