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630 results for “Mycobacterium tuberculosis”
Single Crystal X-ray diffraction data for Mycobacterium tuberculosis BioA
<p>Single crystal X-ray diffraction data for MtBioA related to PDBID: xxxx</p> <p>Data collected at Diamond Light Source, UK</p> <p>Beamline I03</p>
Simulation dataset for "Computational pan-genome mapping and pairwise SNP-distance improve detection of Mycobacterium tuberculosis transmission clusters"
<p>Simulated Illumina reads for SNP distance method evaluation and comparison used in the article "Computational pan-genome mapping and pairwise SNP-distance improve detection of Mycobacterium tuberculosis transmission clusters".</p> <p>Details for simulation can be found at https://gitlab.com/rki_bioinformatics/panpasco/tree/master/simulation_dataset.</p>
Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes
<p>The surface polysacharide arabinomannan (AM) and related glycolipid lipoarabinomannan (LAM) play critical roles in tuberculosis pathogenesis. Human antibody responses to AM/LAM are heterogenous and knowledge of reactivity to specific glycan epitopes at the monoclonal level is limited, especially in individuals who can control <i><span>M. tuberculosis</span></i> infection<span>. </span>We generated human IgG mAbs to AM/LAM from B cells of two asymptomatic individuals exposed to or latently infected with <i><span>M. tuberculosis</span></i>. We here show that two of these mAbs have high affinity to AM/LAM, are non-competing, and recognize different glycan epitopes <span>distinct from other anti-AM/LAM mAbs reported. Both mAbs recognize virulent </span><i><span>M. tuberculosis</span></i><span> and nontuberculous mycobacteria with marked differences, can be used for the detection of urinary LAM, and can detect </span><i><span>M. tuberculosis</span></i><span> and LAM in infected lungs. These mAbs enhance our understanding of the spectrum of antibodies to AM/LAM epitopes </span>in humans <span>and</span> are valuable for <span>tuberculosis</span> diagnostic and research applications.</p>
TMC207-TiDP13-C208: Anti-bacterial Activity, Safety, and Tolerability of TMC207 in Participants With Multi-drug Resistant Mycobacterium Tuberculosis (MDR-TB).
ClinicalTrials.gov study NCT00449644. IPD Sharing: Not stated. Countries: 8. Publications: 5.
Bacille Calmette Guerin (BCG) Revaccination of Healthy Adolescents for the Prevention of Mycobacterium Tuberculosis Sustained Infection
ClinicalTrials.gov study NCT04152161. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety and Immunogenicity of a Mycobacterium Tuberculosis Vaccine M72/AS01E in Participants With Well-controlled HIV
ClinicalTrials.gov study NCT04556981. IPD Sharing: YES. Countries: 1. Publications: 1.
<em>Mycobacterium tuberculosis</em> triggers reduced inflammatory cytokine responses and virulence in mice lacking Tax1bp1
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Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes
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Assessing the sociodemographic factors associated with Mycobacterium tuberculosis complex infection among free-ranging long-tailed Macaques in Thailand
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Dexamethasone inhibits Mycobacterium tuberculosis-induced glycolysis but preserves antimicrobial function in primary human macrophages.
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Antigen-specific CD4+ T cells promote monocyte recruitment and differentiation into glycolytic lung macrophages to control Mycobacterium tuberculosis
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Targeted metabolomics data for dimethyl-ribityl lumazine (DMRL) and riboflavin in Mycobacterium tuberculosis and Mycolicibacterium smegmatis mutants of the riboflavin biosynthetic pathway
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Mass spectrometry data from: Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens
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Large Scale Computational Analysis of Coding and Non-coding Element Expression in Mycobacterium tuberculosis Unannotated CDS
<p>Large Scale Computational Analysis of Coding and Non-coding Element Expression in Mycobacterium tuberculosis Unannotated CDS data for the Applied Medical Science MSci Research Project. </p>
Data for paper "Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors..."
<p>FILES containd dataset for paper:</p> <p><strong>Characterization of new, efficient <em>Mycobacterium tuberculosis</em> topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters</strong></p> <p> </p> <p>Csilla Temesszentandrási-Ambrus<sup>1,2</sup>, Balázs Sarkadi<sup>1</sup>, Gergely Szakács<sup>1</sup>, Szilárd Tóth<sup>1</sup>, László Őrfi<sup>3,4</sup>, Csaba Szántai-Kis<sup>3</sup>, Péter Bánhegyi<sup>3</sup>, István Szabadkai<sup>3</sup>, Ferenc Baska<sup>3</sup>, Ruben C. Hartkoorn<sup>5</sup>, Rinkee Verma<sup>6</sup>, Valakunja Nagaraja<sup>6</sup>, Mary A Lingerfelt <sup>7</sup>, Sean Ekins<sup>7</sup> and Ágnes Telbisz<sup>1,*</sup></p> <p> </p> <p>This work is dedicated to late Prof. György Kéri, founder and CEO of Vichem Ltd.</p> <p> </p> <p><sup>1</sup> Institute of Enzymology, RCNS-HAS, Budapest, Hungary</p> <p><sup>2</sup> Molecular Medicine Doctoral School, Semmelweis University, Budapest, Hungary</p> <p><sup>3</sup> Vichem Chemie Research Ltd., Budapest, Hungary.</p> <p><sup>4 </sup>Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary</p> <p><sup>5</sup> Chemical Biology of Antibiotics, Center for Infection and Immunity, Inserm, CNRS, Institut Pasteur de Lille, Université de Lille, Lille, France</p> <p><sup>6</sup> Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India</p> <p><sup>7</sup> Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, USA</p> <p> </p> <p> </p> <p>*Corresponding author:</p> <p>e-mail: telbisz.agnes@ttk.mta.hu<br> </p>
Evaluating the contributions of purifying selection and progeny-skew in dictating within-host Mycobacterium tuberculosis evolution
<p class="BodyA"><span><span><span><span><span><span><span><span><span><span>The within-host evolutionary dynamics of TB remain unclear, and underlying biological characteristics render standard population genetic approaches based upon the Wright-Fisher model largely inappropriate. In addition, the compact genome combined with an absence of recombination is expected to result in strong purifying selection effects. Thus, it is imperative to establish a biologically-relevant evolutionary framework incorporating these factors in order to enable an accurate study of this important human pathogen. Further, such a model is critical for inferring fundamental evolutionary parameters related to patient treatment, including mutation rates and the severity of infection bottlenecks. We here implement such a model and infer the underlying evolutionary parameters governing within-patient evolutionary dynamics. Results demonstrate that the progeny skew associated with the clonal nature of TB severely reduces genetic diversity and that the neglect of this parameter in previous studies has led to significant mis-inference of mutation rates. As such, our results suggest an underlying <i>de novo</i> mutation rate that is considerably faster than previously inferred, and a progeny distribution differing significantly from Wright-Fisher assumptions. This inference represents a more appropriate evolutionary null model, against which the periodic effects of positive selection, associated with drug-resistance for example, may be better assessed.</span></span></span></span></span></span></span></span></span></span></p>
Mycobacterium tuberculosis FtsB and PerM interact via a C-terminal helix: MD trajectories and microscopy data
<p>Data accompanying the manuscript "Mycobacterium tuberculosis FtsB and PerM interact via a C-terminal helix in FtsB to modulate cell division" currently published at bioRxiv at https://doi.org/10.1101/2024.03.11.584518</p> <p>Molecular dynamics trajectories (only protein atoms to limit size) are provided to reproduce analysis in the paper.<br><br>Raw microscope image data is provided to reproduce analysis and figures in the paper.</p> <p>Other files and scripts required to reproduce the paper are available at https://github.com/smmlab/mtb-perm-ftsb</p>
Data and Scripts for "Timing matters in Macrophage / CD4+ T cell interactions: An agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals"
<p>This contains the data and graphing scripts necessary to recreate all figures in the paper "Timing matters in Macrophage / CD4+ T cell interactions: An agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals". Supplemental Material for the paper is also provided here. Please refer to the README.md for instructions on how to use. The model can be found at: https://github.itap.purdue.edu/ElsjePienaarGroup/LTBINaiveinvitroModel/ along with the uncalibrated parameter files and scripts to run on HPCs.</p>
Data from: Risk factors associated to a high Mycobacterium tuberculosis complex seroprevalence in wild boar (Sus scrofa) from a low bovine tuberculosis prevalence area
<p>Animal tuberculosis is a worldwide zoonotic disease caused principally by <i>Mycobacterium bovis,</i> a member of the <i>Mycobacterium tuberculosis complex </i>(MTC). In southern Iberian peninsula, wild reservoirs such as the wild boar, among other factors, have prevented the eradication of bovine tuberculosis. However, most of the studies have been focused on south-central Spain, where the prevalence of tuberculosis is high among wild ungulates and cattle herds. In northern regions, where wild boar density and bovine tuberculosis prevalence are lower, fewer studies have been carried out and the role of this species is still under debate. The aim of this study was to describe the temporal and spatial distribution of antibodies against MTC in wild boar from the Basque Country, northern Spain. Sera from 1902 animals were collected between 2010 and 2016. The seroprevalence was determined with an in house enzyme-linked immunosorbent assay and the search of risk factors was assessed by Generalized Linear Models. Overall, 17% of wild boars (326/1902; 95%CI, [15.5%–18.9%]) showed antibodies against MTC. Risk factors associated with seropositivity were the year and location of sampling, the number of MTC positive cattle, the distance to positive farms and the percentage of shrub cover. Age was associated with increased antibody titres among seropositive individuals. The seroprevalence detected was higher than those previously reported in neighbouring regions. Hence, further studies are needed to better understand the role of wild boar in the epidemiology of tuberculosis in low tuberculosis prevalence areas and consequently, its relevance when developing control strategies.</p>
Lipidomic profiling of Mycobacterium tuberculosis treated with JCP276, BMB034, or THL
<p><span><span><span><span><span><span><span><span><span><span><span>The increasing incidence of antibiotic-resistant <i>Mycobacterium tuberculosis </i>infections is a growing global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis of the mycobacterial cell envelope. We screened a library of small molecules containing serine-reactive electrophiles and identified a series of narrow spectrum inhibitors of <i>M. tuberculous </i>growth. Using these lead molecules we performed competitive activity-based protein profiling and identified SH targets, including enzymes with uncharacterized functions. Lipidomic analyses of compound-treated cultures revealed an accumulation of free lipids and a substantial decrease in lipooligosaccharides, linking SH inhibition to defects in cell envelope biogenesis. Mutant analysis revealed a path to resistance via the synthesis of mycocerates, but not through mutations to target enzymes. We conclude that simultaneous inhibition of multiple SH enzymes is likely to be an effective therapeutic strategy.</span></span></span></span></span></span></span></span></span></span></span></p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.