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83
datasets available to search
ShareScore release 0.9.0
Dataset results
83 results for “NMDA”
Study of NMDA Antagonists and Neuropathic Pain
ClinicalTrials.gov study NCT01602185. IPD Sharing: Not stated. Countries: 1. Publications: 1.
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
ClinicalTrials.gov study NCT02994433. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Preventing pAIn With NMDA Antagonists - Steroids in Thoracoscopic lObectomy Procedures (PAIN-STOP) Pilot Trial
ClinicalTrials.gov study NCT02950233. IPD Sharing: NO. Countries: 2. Publications: 1.
Antibody-mediated NMDA Receptor Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Prolonged Recovery Stage
ClinicalTrials.gov study NCT06183788. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Data from: A circuit mechanism for decision making biases and NMDA receptor hypofunction
Open the record for dataset details and reuse information.
Data from: NMDA receptor antagonists and pain relief: a meta-analysis of experimental trials
OBJECTIVES: We conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of N-methyl-D-aspartate receptor (NMDAR) antagonists. METHODS: Six major databases were systematically searched (to 03/2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis. RESULTS: Searches identified 70 eligible trials (N=1069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease in the size of hyperalgesic area (Standardized Mean Difference=0.54, CI95[0.34, 0.74], p<.001), and a 1.2-point decrease (CI95[0.88, 1.44], p<.001) in pain ratings from 4.6 to 3.4 on a 0-10 scale (a 26% reduction). Similar analgesia was observed for acute and hyperalgesic models and was constant across the dosing range (0.03-1.00 mg/kg). Moderate-high variability in effect size was observed and mild side effects (e.g. sedation, sensory disturbance) were common. No effects of dextromethorphan were found. CONCLUSIONS: Findings provide robust evidence for analgesic and anti-hyperalgesic effects of ketamine, supporting its utility for acute and chronic pain management. However, pain relief was modest, suggesting ketamine may potentially be most useful when opioids are contraindicated, rapid analgesia is required or for pain resistant to conventional medication.
Structural Insights into binding of therapeutic channel blockers in NMDA receptors
<p>MD simulation data and associated python analysis scripts.</p>
Facilitation of NMDA Receptor Function in Patients With Schizophrenia and Co-morbid Alcoholism
ClinicalTrials.gov study NCT00338598. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
ClinicalTrials.gov study NCT00205712. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus
ClinicalTrials.gov study NCT03336398. IPD Sharing: Not stated. Countries: 1. Publications: 0.
N-acetylcysteine and NMDA Antagonist Interactions
ClinicalTrials.gov study NCT00611897. IPD Sharing: Not stated. Countries: 1. Publications: 0.
NMDA Antagonists in Bipolar Depression
ClinicalTrials.gov study NCT01833897. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking
ClinicalTrials.gov study NCT00218465. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: NMDA receptor antagonists and pain relief: a meta-analysis of experimental trials
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Identification of synaptoneurosomal transcriptome engaged into translation in response to NMDA-R stimulation
GEO Series GSE122724. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for Histone Deacetylase 4
GEO Series GSE54708. Mus musculus. 19 samples. Type: Expression profiling by array.
Epileptic phenotypes in slc13a5 loss-of-function zebrafish are rescued by blocking NMDA receptor signaling
GEO Series GSE275235. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
HDAC2 in primary sensory neurons constitutively restrains chronic pain by repressing α2δ-1 expression and associated NMDA receptor activity
GEO Series GSE145125. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
NMDA receptor positive allosteric modulator induced genome wide gene expression changes in neuronal cultures
GEO Series GSE139080. Rattus norvegicus. 8 samples. Type: Expression profiling by high throughput sequencing.
GLP-1 directed NMDA receptor antagonism for obesity treatment [II]
GEO Series GSE245727. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.