Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
159
datasets available to search
ShareScore release 0.9.0
Dataset results
159 results for “Nucleus accumbens”
Data from: Sex-specific gene expression in the mouse nucleus accumbens before and after cocaine exposure
Females are more sensitive than males to the addictive effects of cocaine and are more likely to relapse. The nucleus accumbens has a well-established major role in the response to cocaine, and sex-specific differential expression of key transcripts at baseline and after cocaine withdrawal could underlie some of these differences. To address this hypothesis, four groups of mice (cycling females, ovariectomized females treated with estradiol or placebo and males) were evaluated for open field activity following 7 daily injections of saline or cocaine. Sensitization to the locomotor effects of cocaine was most pronounced in ovariectomized mice receiving estradiol, was greater in cycling females than in males, and failed to occur in ovariectomized/placebo mice. After a 28-day period of withdrawal, RNA prepared from the nucleus accumbens of individual cocaine or saline injected mice was subjected to RNASeq analysis. Expression of a substantial fraction of the transcripts expressed in the nucleus accumbens (~3%) differed in cycling female mice when compared to male mice, was altered by ovariectomy or was responsive to estradiol treatment. The transcripts differentially expressed in the nucleus accumbens of cycling female mice withdrawn from cocaine for 28-days exhibited substantial overlap with those differentially expressed in the nucleus accumbens of male mice withdrawn for 7-days. A small set of transcripts were similarly affected by cocaine in placebo or estradiol treated ovariectomized mice. Transcripts differentially expressed after 28-days of withdrawal encoded neprilysin, which degrades enkephalin and other neuropeptides, G protein coupled receptors and secreted proteins such as Wnt2, Fst and Igfbp4.
Imaging the Nucleus Accumbens in Major Depressed Patients 'Treated With Pramipexole
ClinicalTrials.gov study NCT01066897. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Infection of male rats with Toxoplasma gondii results in enhanced delay aversion and neural changes in the nucleus accumbens core
Open the record for dataset details and reuse information.
Data from: Sex-specific gene expression in the mouse nucleus accumbens before and after cocaine exposure
Open the record for dataset details and reuse information.
Chromatin accessibility underlies cell-type specific programs of amphetamine-regulated gene expression in Nucleus Accumbens interneurons [Nuclear and Ribo-tag RNA-seq]
GEO Series GSE181419. Mus musculus. 90 samples. Type: Expression profiling by high throughput sequencing.
Next-generation sequencing of cholinergic interneurons in the nucleus accumbens of cocaine-addicted and non-addicted mice
GEO Series GSE130376. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Cocaine-context memories are transcriptionally encoded in nucleus accumbens Arc ensembles
GEO Series GSE289612. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens [snRNA-seq]
GEO Series GSE307587. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Enhanced upregulation of CRH mRNA expression in the rat nucleus accumbens after a delayed second injection of methamphetamine
GEO Series GSE46717. Rattus norvegicus. 24 samples. Type: Expression profiling by array.
Distinct reward processing by subregions of the nucleus accumbens
GEO Series GSE222274. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
circRNAs in the mouse nucleus accumbens (ventral striatum) after cocaine conditioned place preference (CPP)
GEO Series GSE153377. Mus musculus. 6 samples. Type: Non-coding RNA profiling by array.
Genome-wide RNA-sequencing differences in nucleus accumbens of smokers vs. nonsmokers
GEO Series GSE171936. Homo sapiens. 223 samples. Type: Expression profiling by high throughput sequencing.
Translational profiling of hypothalamic and midbrain neurons that project to the nucleus accumbens.
GEO Series GSE55800. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder
GEO Series GSE174409. Homo sapiens. 80 samples. Type: Expression profiling by high throughput sequencing.
Early-life stress and ovarian hormones alter transcriptional regulation in the nucleus accumbens resulting in sex-specific responses to cocaine [RNA-Seq]
GEO Series GSE229695. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Integrative analysis of sex-specific microRNA networks following stress in mouse nucleus accumbens
GEO Series GSE90962. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens [Spatial Transcriptomics]
GEO Series GSE307586. Homo sapiens. 38 samples. Type: Other.
Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers
GEO Series GSE147040. Homo sapiens. 221 samples. Type: Methylation profiling by genome tiling array.
Genes associated with alcohol abuse and nicotine addiction in the human nucleus accumbens
GEO Series GSE20568. Homo sapiens. 20 samples. Type: Expression profiling by array.
Male specific impact of parental care on gene expression in nucleus accumbens
GEO Series GSE229256. Microtus ochrogaster. 25 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.