Find research datasets worth reusing

Study in Primary Care Evaluating Inclisiran Delivery Implementation + Enhanced Support

ClinicalTrials.gov study NCT04807400. IPD Sharing: YES. Countries: 1. Publications: 2.

Collaborating to Heal Addiction and Mental Health in Primary Care

ClinicalTrials.gov study NCT04600414. IPD Sharing: YES. Countries: 1. Publications: 1.

closedIPD-NOFeb 2026View details →

Digital Treatments for Opioids and Other Substance Use Disorders in Primary Care

ClinicalTrials.gov study NCT05160233. IPD Sharing: NO. Countries: 1. Publications: 2.

closedIPD-NOFeb 2026View details →

A Transdiagnostic Course for Common Mental Health Problems in Primary Care

ClinicalTrials.gov study NCT04522713. IPD Sharing: NO. Countries: 1. Publications: 1.

Implementing Evidence-Based Mental Health Practices in Primary Care

ClinicalTrials.gov study NCT00996775. IPD Sharing: YES. Countries: 1. Publications: 3.

PRimary Care Opioid Use Disorders Treatment (PROUD) Trial

ClinicalTrials.gov study NCT03407638. IPD Sharing: YES. Countries: 1. Publications: 7.

opencc-zeroAug 2020View details →

Data from: Evaluation of a pharmacist-led actionable audit and feedback intervention for improving medication safety in primary care: an interrupted time series analysis

Background. We evaluated the impact of a pharmacist-led Safety Medication dASHboard (SMASH) intervention on medication safety in primary care. Methods and findings. SMASH comprised: (1) training of clinical pharmacists to deliver the intervention; (2) a web-based dashboard providing actionable, patient-level feedback; and (3) pharmacists reviewing individual at-risk patients, and initiating remedial actions or advising general practitioners on doing so. It was implemented in forty-three general practices covering a population of 235,595 people in Salford (Greater Manchester), UK. All practices started receiving the intervention between 18 April 2016 and 26 September 2017. We used an interrupted time series analysis of rates of potentially hazardous prescribing and inadequate blood-test monitoring, comparing observed rates post-intervention to extrapolations from a 24-month pre-intervention trend. The number of people registered to participating practices and having one or more risk factors for being exposed to hazardous prescribing or inadequate blood-test monitoring at the start of the intervention was 47,413 (males: 23,073 [48.7%]; mean age: 60 [standard deviation: 21]). At baseline, 95% of practices had rates of potentially hazardous prescribing (composite of 10 indicators) between 0.88% and 6.19%. The prevalence of potentially hazardous prescribing reduced by 27.9% (95% confidence interval [CI], 20.3% to 36.8%) at 24 weeks and by 40.7% (95% CI, 29.1% to 54.2%) at twelve months after introduction of SMASH. The rate of inadequate blood-test monitoring (composite of 2 indicators) reduced by 22.0% (95% CI, 0.2% to 50.7%) at 24 weeks and by 23.5% (95% CI, -4.5% to 61.6%) at 12 months. After 12 months, 95% of practices had rates of potentially hazardous prescribing between 0.74% and 3.02%. We did not randomise practices but enrolled them in a naturalistic fashion. All our measurements were based on routinely kept electronic health records. Conclusions. The SMASH intervention was associated with reduced rates of potentially hazardous prescribing and inadequate blood-test monitoring in general practices. This reduction was sustained over 12 months after start of the intervention for prescribing but not for monitoring of medication. There was a marked reduction in the variation in rates of high-risk prescribing between practices.

opencc-zeroNov 2020View details →

Data from: Models of community-based primary care for epilepsy in low and middle income countries

Objective: To review systematically community-based primary care interventions for epilepsy in low and middle income countries to rationalize approaches and outcome parameters in relation to epilepsy care in these countries. Methods: A systematic search of PubMed, EMBASE, Global Index Medicus, CINAHL and Web of Science was undertaken to identify trials and implementation of provision of anti-seizure medications, adherence reinforcement and/or healthcare provider or community education in community-based samples of epilepsy. Data on populations addressed, interventions and outcomes were extracted from eligible articles. Results: Twenty-four reports were identified, mostly care programs addressing active convulsive epilepsy. Phenobarbital has been used most frequently though other conventional antiseizure medications have also been used but none of the newer. Tolerability rates in these studies are high but overall, attrition is considerable. Other approaches have included updating primary health care providers, reinforcing treatment adherence in clinics and raising community awareness. The coverage of existing treatment gap in the community, epilepsy-related mortality and comorbidity burden are fleetingly addressed in these programs. Conclusions: The cost-free provision, mostly of phenobarbital has resulted in short-term seizure freedom in roughly half of the people with epilepsy in LMICs. Future programs should include a range of antiseizure medications. These should cover apart from seizure control and treatment adherence, primary healthcare provider education, raising community awareness and referral protocols for specialist care. The programs should ensure sustainability and impact assessment at a community level.

opencc-by-4.0May 2021View details →

Study protocol and data dictionary: Effectiveness of a GP delivered medication review in reducing polypharmacy and potentially inappropriate prescribing in older patients with multimorbidity in Irish primary care: a cluster randomised controlled trial (SPPiRE study)

Methods Study design and participants The methods for the SPPiRE cluster RCT have been described in the trial protocol (21). This study is reported in line with the CONSORT 2010 cluster RCT checklist (22), see Appendix 1, and was approved by the Irish College of General Practitioners Research Ethics Committee. In brief, SPPiRE was a pragmatic two arm cluster RCT, with the intervention delivered to GP clusters and analysis of outcomes at the patient level. Information about the trial was publicised through a variety of GP research, teaching and training networks throughout Ireland. Eligible practices expressing an interest were formally invited. Practices were eligible to participate if they had at least 300 registered patients aged ≥65 years (based on the need to identify a sufficient number of eligible participants) and used either of the two Irish GP practice management systems (PMS) with over 80% national cover; this enabled use of a SPPiRE patient finder tool which was developed and embedded into these systems. Practices were excluded if they were currently involved in a medication management or prescribing trial or if they were unable to recruit at least five participants. Eligible patients were aged ≥65 years and prescribed ≥15 repeat medicines. A repeat medicine was defined as any unique item with a World Health Organisation Anatomical Therapeutic Chemical code on the patient’s current repeat prescription. Patients were excluded if they had been recruited into a practice that was unable to recruit at least four other participants, they were judged by their GP as unable to give informed consent or they were unable to attend the practice for a face to face medication review, (e.g. nursing home residents and house bound patients).  Recruited GPs ran the SPPiRE patient finder tool and screened the generated list to ensure only eligible patients were invited. Practices who identified more than 40 eligible patients were supported in selecting a random sample of 30 patients to invite. All recruited practices and patients gave fully informed consent and baseline data was collected prior to practice allocation, to reduce the likelihood of selection bias. Randomisation and masking Recruited practices were allocated to intervention or control groups by minimisation using Minimpy software (23) by the trial statistician (FB) who had no knowledge of participating practices. Minimisation variables included practice size (number of GP sessions per week, 0-14, 14-28 and 28 or more) and location (urban, rural or mixed). Considering the nature of the intervention, it was not possible to blind GPs or patients to the intervention, however to reduce the risk of detection bias the two primary outcome measures; the number of repeat medicines and whether a PIP was present were assessed by an independent blinded pharmacist (MF). Procedures Intervention GPs received unique login details to the SPPiRE website where they had access to five training videos and a template for performing the SPPiRE medication review. The training videos provided background information on multimorbidity and polypharmacy, PIP, eliciting patient treatment priorities and conducting a brown bag medication review. GPs were instructed to book a double appointment and to ask their patients to bring all their medicines in to the medication review visit with them. The SPPiRE medication review process had two main components; gather and record information and then to discuss and agree changes with their patient based on the recorded information, with a focus on deprescribing medicines that were potentially inappropriate, figure 1. The website provided suggested treatment alternatives for identified PIP but all treatment decisions were ultimately at the discretion of the individual GP, based on their clinical judgement and their patients’ individual priorities. Control GPs delivered usual care during the six to twelve month study period. At the time of intervention delivery there was no structured chronic disease management programme in Irish primary care and many patients with multimorbidity attended multiple hospital specialists. In Ireland, the majority of people aged ≥70 years of age have access to free GP visits and medicines with some prescription charge co-payments. In the 65 – 69 year old age category a lower proportion have access to both free GP visits and prescription medicines. Access to specialists and diagnostics in secondary care is free for the entire population. Outcomes The two primary outcomes were the number of repeat medicines and the proportion of patients with any PIP, from a list of 34 pre-specified indicators (see Appendix 2). A series of secondary prescribing related outcome measure were pre-specified to allow a more in depth analysis of the effect of the intervention on prescribing. These were: <ul> <li>The number of medicines stopped and started</li> <li>The proportion of patients with a reduction in significant polypharmacy (defined as ≥15 repeat medicines)</li> <li>The number of PIP</li> <li>The proportion of patients with a high risk PIP (see Appendix 2)</li> <li>The proportion of patients with any reduction in PIP</li> </ul> Secondary patient reported outcomes measures were included to capture the effectiveness of the intervention from the patients’ perspective. These were: <ul> <li>Health related Quality of life (EQ5D-5L)(24)</li> <li>Revised Patients' attitudes towards deprescribing (rPATD)  (25)</li> <li>Multimorbidity Treatment Burden Questionnaire (MTBQ) (26)</li> </ul> Health care utilisation data was collected to assess the effect of the intervention on health care usage and for the trial’s economic evaluation. Outcomes were collected at baseline and at six months after intervention delivery. Patient reported measures were collected by postal questionnaires. Data for all other measures including prescribed medicines, medical and investigations history and healthcare utilisation were collected by participating GPs and submitted to the study manager (CMC). This was a deviation from the original protocol, which indicated this data would be collected by the research team. This deviation related to changes in data protection and national health research regulations during the study period, which precluded research team access to the patients’ full clinical record. Adverse events Information on adverse events such as mortality, ED presentations and hospital admissions was collected at follow up. Given the deprescribing approach of the intervention a safety protocol for identifying and reporting any suspected adverse drug withdrawal events (ADWEs) was developed. An ADWE is defined as either recurrence of the condition for which the drug was prescribed (e.g. recurrence of angina after stopping a beta blocker) or a physiologic reaction to drug withdrawal (e.g. SSRI withdrawal syndrome)  (27, 28). Although discontinuing medicines in older people has been demonstrated to be safe (29), given the paramount importance of the principle of “do no harm” in research ethics a vigorous and detailed method was established to ensure that any potential ADWEs precipitated by deprescribing in a SPPiRE medication review were captured. Intervention GPs were asked to report any possible ADWE following the SPPiRE medication review. The Naranjo ADR probability scale (30) has been adapted in other studies to assess the likelihood a reaction is related to drug withdrawal  (27, 28). This tool was further adapted for SPPiRE and used to make an assessment on the causality of the ADWE. To ensure the patient perspective was included, self-reported possible ADWEs were also collected from patient follow up questionnaires.     Sample size As outlined in the trial protocol (21), the study was designed with 90% power to detect a 20% reduction in the proportion with PIP and a mean difference of one medicine between intervention and control groups (based on a mean of 17.4 medicines SD (2.6)) and the sample size inflated to incorporate the effects of clustering (using an ICC of 0.025). The sample size was recalculated when it became apparent during early recruitment that it would not be possible to recruit clusters with an average of 15 participants, as was initially planned in the protocol. An average cluster size of eight was anticipated which inflated the original sample size from 30 practices (450 patients) to 50 practices (400 patients). Statistical analysis Descriptive statistics were used to describe baseline characteristics of recruited practices and participants. All analyses were conducted under the intention-to-treat principle and those lost to follow up had their baseline data carried forward. The primary analysis was carried out using multi-level modelling. The first primary outcome measure, number of repeat medications, was assessed using mixed effects Poisson regression with the individual as the unit of analysis and the practice included as the random effect to control for the effects of clustering and results presented using incidence rate ratios (IRR) and 95% confidence intervals (CI). The baseline number of medicines, GP size (number of GP sessions per week) and GP location (urban/rural) were included in the analysis as fixed effects. The second outcome measure, proportion of patients with a PIP, was analysed in a similar manner using mixed effects logistic regression, including PIP at baseline, GP size and location, and results presented using odd ratios (OR) and 95% CIs. A number of pre-specified sensitivity analyses were conducted; complete case analysis, per protocol analysis and including “presence of a repeat prescribing policy” as a covariate. All secondary outcomes were analysed in a similar manner to the primary outcomes, using appropriate mixed effects regression methods (i.e. linear, logistic, Poisson).   Note: Version 3 (published 28 April 2025) updates Version 2 by removing Participant GP1P4 following consent withdrawal. This version should be used for all future analyses.

opencc-by-4.0Dec 2023View details →

Knowledge of Primary Health Care Nurses at Selected Public Institutions Regarding Prescription of Antihypertensive Drugs

Hypertension has been among the most studied topics of the previous century and has been one of the most significant comorbidities contributing to the development of stroke, myocardial infarction, heart failure, and renal failure. In the mist of that, there is limited data on nurses’ knowledge regarding prescription of antihypertensive drugs in Lesotho. The aim of this study was to assess primary health care nurses’ knowledge regarding prescription of antihypertensive drugs. Quantitative descriptive cross-sectional study of primary health care nurses recruited by purposive sampling was conducted. An electronic questionnaire was used to collect data and data were analyzed using descriptive statistics. Most participants were females and had attained diploma in general nursing and midwifery. A proportion of 26% fully knew the steps to be followed for diagnosing hypertension and only 23% felt highly confident to initiate patients on antihypertensive drugs. Moreover, knowledge on mechanism of action of antihypertensive drugs was poor and less than half only knew antihypertensive drug of choice when there is comorbidity. The study identified that nurses have knowledge deficit regarding prescription of antihypertensive drugs. There is a need for interventions to improve nurses’ knowledge so as to curb hypertension burden.

opencc-by-sa-4.0Oct 2017View details →

"Abdominal pain in emergency departments in a well-developed primary care system, a retrospective observational study"

This is the dataset that is used for the original article: “Abdominal pain in emergency departments in a well-developed primary care system, a retrospective observational study”

opencc-zeroJun 2024View details →

Doubts about the diagnosis and treatment of syphilis in pregnancy among primary care professionals in a telehealth service

<div> <div> <div> <div>This cross-sectional study aims to describe doubts regarding the diagnosis and treatment of syphilis in pregnancy among primary care professionals in a telehealth service. All teleconsultations (TCs) offered through TelessaúdeRS-UFRGS to primary health care (PHC) services in a state in southern Brazil involving syphilis in pregnancy were included. A total of 356 (TCs) were analyzed.</div> <div> </div> </div> </div> </div> <div> <div> <div> <div>The main doubts about syphilis during pregnancy raised by primary care professionals were related to the need for retreatment (35%), diagnostic definition (23%), and initial treatment (16%). In addition, 95% of TCs were suitable for diagnosing and treating syphilis based on the Brazilian Ministry of Health guidelines. This study suggests that TCs can identify failures in the diagnosis and treatment of public health problems and support decision-making in PHC involving syphilis in pregnancy.</div> </div> </div> </div>

opencc-by-4.0Dec 2017View details →

Isoniazid Preventive Therapy (IPT) uptake and Tuberculin Skin Test (TST) uptake among adults receiving primary HIV care in South Africa .

We aimed to evaluate Isoniazid Preventive Therapy (IPT) and tuberculin skin testing (TST) uptake under primary care clinic conditions, and determine health care worker (HCW) fidelity to the 2014 South African IPT guidelines. Following training on IPT guidelines and tuberculin skin testing (TST), 3 primary care clinics identified their IPT implementation strategy in a participatory manner. Using routine register data, TST uptake was determined 3 months before and 5 months after the intervention. Records were reviewed to identify IPT/TST uptake and factors associated with IPT initiation among adults living with HIV.

opencc-by-4.0Oct 2024View details →

Supporting information for: The Time Requirements for Primary Care Consultations: Initial Sick Child Visits in Low- and Middle-income Countries Using the Integrated Management of Childhood Illness (IMCI) Clinical Algorithm

Few studies have examined the time required for primary care consultations; none have focused on sick child visits in low- and middle-income countries (LMICs). This project begins to fill that gap by providing evidence-based estimates of the time needed for initial visits with under-five infants and children at public or not-for-profit facilities in countries using the Integrated Management of Childhood Illness (IMCI) clinical algorithm. Estimates of the mean expected duration of IMCI consultations require (a) classification profiles, i.e., tabulations of the gold standard health issues presented by patients less than 5 years old; (b) lists of the tasks included in applicable versions of the IMCI algorithm and the conditions that elicit them, and (c) an estimate of the time needed to perform tasks with no pre-defined minimum duration. The latter requires, in addition to classification profiles, information on rates of task performance and the mean observed duration of consultations. The IMCI clinical algorithm and the research surrounding it provide unusually rich sources of such information. Developed in the mid 1990s by the World Health Organization and the United Nations Children’s Fund, the IMCI algorithm seeks to reduce child mortality in LMICs by improving the technical quality of primary care services. For infants less than 2 months old, the algorithm focuses on bacterial infections, feeding problems, low weight, and, in some versions, jaundice. For children 2-59 months old, the foci include acute respiratory infections, especially pneumonia; diarrhea; fevers, especially malaria and measles; malnutrition, and anemia. Immunization status is a concern for both age groups. The algorithm provides a scheme to classify the health issues with which infants and children present, an array of tasks providers may be expected perform, and criteria by which tasks are elicited. Research on the design and utility of the algorithm, its effects on provider performance, and related topics furnishes data on the prevalence of gold standard IMCI classifications in a variety of patient populations. In some cases, it also enables one to calculate the time required to perform tasks. I found such information by searching MEDLINE, the database of the International Network for Rational Use of Medicines, the websites of the WHO and its regional offices, GOOGLE, and GOOGLE SCHOLAR using search terms such as ‘Integrated Management of Childhood Illness’, ‘observational’, ‘prospective’, ‘classification’, ‘clinical signs’, ‘health facility survey’, and ‘validity’. I also reviewed studies that cited a qualified study and, conversely, material included in the bibliographies of qualified studies. The supplemental information files contain the following: WORKBOOK S1_STUDIES USED Lists features of, and sources for, the studies used to construct classification profiles and to estimate the time required to perform the average task with no predefined minimum duration. With 2 exceptions (see below, DATA S1 and DATA S2), all the studies have been published or are readily available on the internet. None of the data can be used to identify individuals. DATA S1_REPORT OF THE HEALTH FACILITY SURVEY IN BOTSWANA, 2007-08 and DATA S2_REPORT OF THE HEALTH FACILITY SURVEY IN TANZANIA, 2003 PDF files of Health Facility Survey reports that were found on the internet but have since been taken down. DATA S3_BURKINA FASO CHART BOOKLET, 2015 PDF provided Drs. Sophie Sarrassat (London School of Hygiene and Tropical Medicine) and Serge M. A. Somda (Université Nazi BONI). WORKBOOK S2_CLASSIFICATION PROFILES: INFANTS; WORKBOOK S3_CLASSIFICATION PROFILES: CHILDREN IN UPPER MIDDLE-INCOME COUNTRIES; WORKBOOK S4_CLASSIFICATION PROFILES: CHILDREN IN LOWER MIDDLE-INCOME COUNTRIES (I); WORKBOOK S5_CLASSIFICATION PROFILES: CHILDREN IN LOWER MIDDLE-INCOME COUNTRIES (II), and WORKBOOK S6_CLASSIFICATION PROFILES: CHILDREN IN LOW INCOME COUNTRIES                                                                                                           The design of the worksheets in these workbooks is described in TEXT S1_NOTES OF THE CONSTRUCTION OF CLASSIFICATION PROFILES (see below). WORKBOOK S7_IMCI CLINICAL TASKS Lists the clinical tasks provided by relevant IMCI algorithms for the care of infants and children. Consists of 6 worksheets covering mandatory tasks, conditional assessments, and treatment and counseling tasks for infants and children. WORKBOOK S8_MINUTES PER TASK WITH NO MINIMUM DURATION Provides estimate of the mean time required to perform a task with no minimum duration for each of 7 populations for which the required data are available, corrected, where necessary, for the effect of an observer on the rate and pace of task performance. Also provides a geometric mean for all 7 populations. TEXT S1_NOTES ON METHODOLOGY WORD document describing the steps involved in estimating the expected durations of consultations. TEXT S2_NOTES OF THE CONSTRUCTION OF CLASSIFICATION PROFILES WORD document describing the steps involved in constructing each profile, problems encountered, and how they were solved. TEXT S3_NOTES ON THE IDENTIFICATION OF IMCI CLINICAL TASKS WORD document describing the standards used in identifying clinical tasks in IMCI algorithms. TEXT S4_NOTES ON THE ESTIMATION OF MINUTES PER TASK WITH NO MINIMUM DURATION WORD document describing the steps involved in estimating the mean time required to perform a task with no predefined minimum duration, problems encountered, and how they were solved.

opencc-by-4.0Oct 2024View details →

Assessing the feasibility and acceptability of a pre-clinic vital signs assessment in primary care: a pilot study.

Open the record for dataset details and reuse information.

opencc-by-4.0Jun 2021View details →

Primary-level worker interventions for the care of mental disorders and distress in low- and middle-income countries - GRADE evidence profiles

This file includes all GRADE evidence profiles for the following Cochrane review: van Ginneken N, Chin WY, Lim YC, Ussif A, Singh R, Shahmalak U, Purgato M, Rojas-García A, Uphoff E, McMullen S, Foss HS, Thapa Pachya A, Rashidian L, Borghesani A, Henschke N, Chong L-Y, Lewin S. Primary-level worker interventions for the care of mental disorders and distress in low- and middle-income countries. Cochrane Database of Systematic Reviews. In press