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Dataset results
75 results for “Plasma proteins”
Evaluation of a Plasma Protein Profile as a Predictive Biomarker for Metastatic Relapse in Triple Negative Breast Cancer Patients
ClinicalTrials.gov study NCT04438681. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients
ClinicalTrials.gov study NCT03557840. IPD Sharing: NO. Countries: 1. Publications: 21.
First-in-Human Study of an Oral Plasmodium Falciparum Plasma Membrane Protein Inhibitor
ClinicalTrials.gov study NCT02661373. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Dietary Fat Type in Combination With High Protein on Plasma Homocysteine Levels
ClinicalTrials.gov study NCT00941837. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Investigation of Plasma Proteins in Patients With Hereditary Haemorrhagic Telangiectasia and PAVMs
ClinicalTrials.gov study NCT00230672. IPD Sharing: NO. Countries: 1. Publications: 1.
Dietary Intervention Replacing Carbohydrate With Protein and Fat Has Greater Effect on Peripheral Blood Mononuclear Cell Metabolites Than on Plasma Metabolites in Patients With Prediabetes or Type-2 D
ClinicalTrials.gov study NCT02191644. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Changes in Plasma Amino Acid Appearance After Adding Bacillus Coagulans GBI-30, 6086 to Milk Protein Concentrate
ClinicalTrials.gov study NCT05313178. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
The central nervous system (CNS) insults may cause massive demyelination and lead to the release of myelin-associated proteins including its major component myelin basic protein (MBP). MBP is reported to induce glial activation but its effect on neurons is still little known. Here we found that MBP specifically bound to the extracellular surface of the neuronal plasma membrane and induced neurotoxicity in vitro. This effect of MBP on neurons was basicity-dependent because the binding was blocked by acidic lipids and competed by other basic proteins. Further studies revealed that MBP induced damage to neuronal membrane integrity and function by depolarizing the resting membrane potential, increasing the permeability to cations and other molecules, and decreasing the membrane fluidity. At last, artificial liposome vesicle assay showed that MBP directly disturbed acidic lipid bilayer and resulted in increased membrane permeability. These results revealed that MBP induces neurotoxicity through its direct interaction with acidic components on the extracellular surface of neuronal membrane, which may suggest a possible contribution of MBP to the pathogenesis in the CNS disorders with myelin damage.
Guo et al., Table S20 - Global analysis of the heparin-enriched plasma proteome captures matrisome-associated proteins in Alzheimer's disease
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Supplemental methods for: Circulating plasma proteins differentiate epileptic from psychogenic non-epileptic seizures
<p><b>Objective:</b> To develop a diagnostic test that stratifies epileptic seizure (ES) from psychogenic non-epileptic seizure (PNES) by developing a multimodal algorithm that integrates plasma concentrations of selected immune response associated proteins and patient clinical risk factors for seizure.</p> <p><b>Methods: </b>Daily blood samples were collected from patients evaluated in the epilepsy monitoring unit (EMU) within 24 hours after EEG confirmed ES or PNES and plasma was isolated. Levels of 51 candidate plasma proteins were quantified using an automated, multiplexed, sandwich ELISA and then integrated and analyzed using our diagnostic algorithm.</p> <p><b>Results: </b>A 51 protein multiplexed ELISA panel was used to determine the plasma concentrations of ES patients, PNES patients, and healthy controls. A combination of protein concentrations, TRAIL, ICAM-1, MCP-2 and TNF-R1 were identified that provided a probability that a patient recently experienced a seizure. The diagnostic algorithm yielded an AUC of 0.94 ± 0.07, sensitivity of 82.6% (95% CI: 62.9-93.0) and specificity of 91.6% (95% CI: 74.2-97.7). Further, expanding the diagnostic algorithm to include previously identified PNES risk factors enhanced diagnostic performance with AUC of 0.97 ± 0.05, sensitivity of 91.3%; (95% CI: 73.2-97.6), and specificity of 95.8%; (95% CI: 79.8-99.3).</p> <p><b>Conclusions: </b>We have identified four plasma proteins that could provide a rapid, cost-effective, and accurate blood-based diagnostic test to confirm recent ES or PNES.</p> <p><b>Classification of Evidence</b>: This study provides Class III evidence that variable levels of four plasma proteins, when analyzed by a diagnostic algorithm, can distinguish PNES from ES with sensitivity of 82.6% and specificity of 91.6%.</p>
Plasma Protein Binding Characteristics of Voriconazole
ClinicalTrials.gov study NCT01812473. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins
ClinicalTrials.gov study NCT03315702. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
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Supplemental methods for: Circulating plasma proteins differentiate epileptic from psychogenic non-epileptic seizures
Open the record for dataset details and reuse information.
An inter-chromosomal transcription hub activates the unfolded protein response in plasma cells
GEO Series GSE113014. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Morphological and genetic screens reveal mechanisms of BiDAC-induced plasma membrane protein degradation
GEO Series GSE291219. Homo sapiens. 4 samples. Type: Other.
Dynamic changes in E protein activity orchestrate germinal center and plasma cell development
GEO Series GSE72832. Homo sapiens; Mus musculus. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Plasma protein-profiling to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma (LA-NPC)
GEO Series GSE149587. Homo sapiens. 16 samples. Type: Protein profiling by protein array.
Dynamic changes in E protein activity orchestrate germinal center and plasma cell development [RNA-Seq]
GEO Series GSE72831. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Clinical significance of interferon signal based on mRNA-microRNA integration and plasma protein analyses in the critically ill patients with COVID19
GEO Series GSE182152. Homo sapiens. 62 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.