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ShareScore release 0.9.0
Dataset results
29 results for “Prevention of Mother to Child Transmission of HIV”
Routine Use of Antiretroviral Therapy to Prevent Mother-to-Child HIV Transmission in the Kafue District of Zambia
ClinicalTrials.gov study NCT00753324. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Optimizing prevention of HIV mother to child transmission: duration of antiretroviral therapy and viral suppression at delivery among pregnant Malawian women
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Data from: National-level effectiveness of ART to prevent early mother to child transmission of HIV in Namibia
<p><strong>Background:</strong> Namibia introduced the prevention of mother to child HIV transmission (MTCT) program in 2002 and lifelong antiretroviral therapy (ART) for pregnant women (option B-plus) in 2013. We sought to quantify MTCT measured at 4-12 weeks post-delivery.</p> <p><strong>Methods:</strong> During Aug 2014-Feb 2015, we recruited a nationally representative sample of 1040 pairs of mother and infant aged 4-12 weeks at routine immunizations in 60 public health clinics using two stage sampling approach. Of these, 864 HIV exposed infants had DNA-PCR HIV test results available. We defined an HIV exposed infant if born to an HIV-positive mother with documented status or diagnosed at enrollment using rapid HIV tests. Dried Blood Spots samples from HIV exposed infants were tested for HIV. Interview data and laboratory results were collected on smartphones and uploaded to a central database. We measured MTCT prevalence at 4-12 weeks post-delivery and evaluated associations between infant HIV infection and maternal and infant characteristics including maternal treatment and infant prophylaxis. All statistical analyses accounted for the survey design.</p> <p><strong>Results:</strong> Based on the 864 HIV exposed infants with test results available, nationally weighted early MTCT measured at 4-12 weeks post-delivery was 1.74% (95% confidence interval (CI): 1.00%-3.01%). Overall, 62% of mothers started ART pre-conception, 33.6% during pregnancy, 1.2% post-delivery and 3.2% never received ART. Mothers who started ART before pregnancy and during pregnancy had low MTCT prevalence, 0.78% (95% CI: 0.31%-1.96%) and 0.98% (95% CI: 0.33%-2.91%), respectively. MTCT rose to 4.13% (95% CI: 0.54%-25.68%) when the mother started ART after delivery and to 11.62% (95% CI: 4.07%-28.96%) when she never received ART. The lowest MTCT of 0.76% (95% CI: 0.36% - 1.61%) was achieved when mother received ART and ARV prophylaxis within 72hrs for infant and highest 22.32% (95%CI: 2.78% -74.25%) when neither mother nor infant received ARVs. After adjusting for mother's age, maternal ART (Prevalence Ratio (PR)=0.10, 95% CI: 0.03 – 0.29) and infant ARV prophylaxis (PR=0.32, 95% CI: 0.10 – 0.998) remained strong predictors of HIV transmission.</p> <p><strong>Conclusion:</strong> As of 2015, Namibia achieved MTCT of 1.74%, measured at 4-12 weeks post-delivery. Women already on ART pre-conception had the lowest prevalence of MTCT emphasizing the importance of early HIV diagnosis and treatment initiation before pregnancy. Studies are needed to measure MTCT and maternal HIV seroconversion during breastfeeding.</p>
Community Health Workers and Prevention of Mother-to-Child HIV Transmission in Tanzania
ClinicalTrials.gov study NCT03058484. IPD Sharing: UNDECIDED. Countries: 0. Publications: 6.
Data from: National-level effectiveness of ART to prevent early mother to child transmission of HIV in Namibia
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Clinical Study of an Aluvia-based HAART Regimen for Prevention of Mother-to-child HIV Transmission in Africa
ClinicalTrials.gov study NCT01088516. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nevirapine Clearance After Short-term Highly Active Antiretroviral Therapy (HAART) for Prevention of Mother to Child Transmission of HIV (PMTCT)
ClinicalTrials.gov study NCT00872872. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Retention of Women in the PMTCT (Prevention of Mother-to-child Transmission of HIV)
ClinicalTrials.gov study NCT03213223. IPD Sharing: NO. Countries: 1. Publications: 0.
The Thai Red Cross Society Prevention of Mother-To-Child Transmission of HIV (TRCS PMTCT) Program
ClinicalTrials.gov study NCT02151838. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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