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Dataset results
144 results for “Protein stability”
Data for: Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks
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Raw data for Jin et. al "Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks"
<h2><strong><span>Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks</span></strong></h2> <p><span> </span></p> <p><span>Meiyan Jin<sup>1,2*</sup>, Yuichiro Iwamoto<sup>1</sup>, Cyna Shirazinejad<sup>1</sup>, David G. Drubin<sup>1,3**</sup></span></p> <p><sup><span>1 </span></sup><span>Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA</span></p> <p><sup><span>2</span></sup><span> Current Address: Department of Biology, University of Florida, Gainesville, Fl 32611, USA</span></p> <p><sup><span>3</span></sup><span> Lead author</span></p> <p><sup><span>* </span></sup><span>Correspondence: meiyan.jin@ufl.edu</span></p> <p><sup><span>**</span></sup><span>Correspondence: </span><span>drubin@berkeley.edu</span></p>
Initial and final MD simulation coordinates for "Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization"
<p>Initial and final coordinates for all MD simulations performed for the manuscript: "Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization."</p> <p>File uploaded is a ZIP folder, containing sub-folders for each capsid construct (wild type and mutants). Additionally, a README file is given in the top-level folder, which contains a description of the file contents.</p>
Structure-based self-supervised learning enables ultrafast prediction of stability changes upon mutation at the protein universe scale
<p>Pythia computed all single mutations of <em>E.coli</em> proteome, high quality high quality of Swiss-Prot structures and thermophilic proteins used in analysis.</p>
ProtASR2: Ancestral Reconstruction of Protein Sequences accounting for Folding Stability
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Varibench Protein-stability Compilation
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Enzyme inhibitors employ different mechanisms to stabilize broad-spectrum antiviral ACE2-Fc fusion proteins
<p>Drugs effective for all variants of a virus are urgently needed to fight current and future pandemics. This can be achieved by creating fusion proteins between the extracellular domains of the virus docking sites on human cells and the Fc part from a human immunoglobulin. The angiotensin-converting enzyme 2 (ACE2) is a viral receptor used by sarbeco betacorona-viruses to infect cells. Fusion proteins comprising extracellular ACE2 domains exhibit high virus neutralization efficiency, but the structure and stability of these molecules are poorly understood. Here we analyzed the structure and stability of an ACE2-IgG4-Fc. We show that the hinge between the ACE2 region and the IgG4-FC is highly flexible, and the conformational dynamics of the fusion protein is restricted by the ACE2 domain[MS1] . Interestingly, chemical compounds inhibiting the enzymatic activity of ACE2 such as DX600 and MLN4760 employ different binding mechanisms to increase the thermal stability of the ACE2 by 8.8 and 14.3 °C, respectively. In particular, MLN4760 induced allosteric effects in the ACE2 domain consistent with structural rearrangements observed in the inhibitor-bound crystal structure. Thus, our findings reveal a general concept for stabilizing the labile receptor segment of therapeutic antiviral fusion proteins[MS2] .</p>
Data from: ProtASR: an evolutionary framework for ancestral protein reconstruction with selection on folding stability
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Breast tumor specific mutation in GATA3 impacts protein stability and genomic location
GEO Series GSE51274. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Fission yeast Cactin restricts telomere transcription and elongation by promoting Rap1 pre-mRNA splicing and protein stabilization
GEO Series GSE61792. Schizosaccharomyces pombe. 5 samples. Type: Expression profiling by genome tiling array.
The antiviral nuclear body protein SP140 represses Ifnb1 transcript stabilization by the novel regulator RESIST [RNA-seq]
GEO Series GSE269761. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Neural crest cells bulldoze through the microenvironment using water channel proteins to stabilize filopodia
GEO Series GSE121131. Gallus gallus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics
GEO Series GSE162983. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
IGF2BP proteins Enhance mRNA stability
GEO Series GSE90684. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Regulation of FOXA1 protein stability by Polycomb and BUB3/USP7 deubiquitin complexes in prostate cancer [ChIP-Seq]
GEO Series GSE161517. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture
GEO Series GSE181234. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
ATF7IP inhibits Sorafenib-induced ferroptosis in hepatocellular carcinoma cells by inhibiting CYB5R2 transcription and stabilizing PARK7 protein
GEO Series GSE294091. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Esophageal Squamous Cell Carcinoma tumors from Indian patients: nuclear-stabilized p53 (NS+) versus unstable p53 (NS-) protein
GEO Series GSE218109. Homo sapiens. 36 samples. Type: Expression profiling by array.
Protein-mediated stabilization and nicking of the nontemplate DNA strand dramatically affect R-loop formation in vitro
GEO Series GSE295014. synthetic construct. 65 samples. Type: Methylation profiling by high throughput sequencing; Other.
KIF15 promotes AR and AR-V7 protein stabilization in contribution to enzalutamide resistance of prostate cancers
GEO Series GSE150896. Homo sapiens. 8 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.