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274 results for “Spheroid”
Fig. 3. A in Silicified and phosphatized Tianzhushania, spheroidal microfossils of possible animal origin from the Neoproterozoic of South China
Fig. 3. A. Tianzhushania sp. with possible two−cell stage cleavage from thin sections of chert in the Weng'an area, MESIG 10003 (44/89.6); A1, general view, showing the wall and internal structures; note that the internal body is cleaved into two; arrow shows position of A2; A2, enlarged view of A1, showing details of the structure of the envelope. B. Typical Tianzhushania spinosa Yin and Li, 1978, found in a chert nodule from eastern Yangtze Gorges, MESIG 10006 (40.1/94.2); B1, general view, for comparison with the specimen (Fig. 2A) found in the Weng'an area (arrow shows position of B2); B2, enlarged view of B1, showing details of the structure of the wall (arrow points to external membrane between two bundles of processes).
Fig. 6 in Silicified and phosphatized Tianzhushania, spheroidal microfossils of possible animal origin from the Neoproterozoic of South China
Fig. 6. Phosphatized Tianzhushania ornata (Xiao and Knoll, 2000) comb. nov. in Doushantuo phosphorites at Weng'an. A. MESIG 21042; A2, detail of A1, showing a part of outer covering surrounding the envelope with tubercles. B. MESIG 21045, specimen preserving part of outer covering. C. MESIG 21064; note the internal membrane. D. MESIG 20303, showing shrunken internal body with membrane and secondary overgrowth on internal body. E. MESIG 20190, polygons with fractal branching; note numerous dimples at top. F. MESIG 21076; F2, detail of F1, showing details of irregularly distributed dimples. G. MESIG 21078, polygonal envelope ornamentation; note that dimples also occur on arches. H. MESIG 21009; H2, detail of H1, showing deflated envelope and details of envelope ornamentation. I. MESIG 21026, deflated envelope with envelope ornamentation.
Prediction of Spheroid Cell Death using Fluorescence Staining and Convolutional Neural Networks
<p>This repository contains training, validation, and testing of fluorescence image data sets with their label for spheroid cell death classification. These data are intended to be used in the paper <strong>"Prediction of Spheroid Cell Death using Fluorescence Staining and Convolutional Neural Networks" currently submitted </strong></p>
Spheroids workflow: KapoorLabs
<p>Presentation material for workflow developed for cell segmentation, cell action type classification, tracking and auto track correction with track analysis and track classification for the group of Prof. Chris Bakal at ICR, London.</p>
Stellar Density Profiles of Dwarf Spheroidal Galaxies - Posterior Distributions
<p>This archive contains samples from the posterior distributions of our 3-plummer, 1-plummer, 3-steeper and 1-steeper fits for 40 dwarf spheroidal galaxies as described in "Stellar Density Profiles of Dwarf Spheroidal Galaxies" (<a href="https://arxiv.org/abs/1910.10134">https://arxiv.org/abs/1910.10134</a>)</p>
Well overviews of A549 spheroids at varying cell plating density and Matrigel concentrations
<p>Above images depict well overviews of 5-day old A549 spheroid culture at varied cell plating density (1000,2000 and 3000 cells per well) and Matrigel density (10, 20 and 25 microliters). These were imaged using Perkin Elmer Opera Phenix High Content Screening System and were stained with a nuclear marker (Hoescht 33342) and an actin marker phalloidin/Alexa568.</p>
Well overviews of A549 spheroids at varying cell plating density and Matrigel concentrations
<p>Above images depict well overviews of 5-day old A549 spheroid culture at varied cell plating density (1000,2000 and 3000 cells per well) and Matrigel density (10, 20 and 25 microliters). These were imaged using Perkin Elmer Opera Phenix High Content Screening System and were stained with a nuclear marker (Hoescht 33342) and an actin marker phalloidin/Alexa568.</p>
Involvement of the optic nerve in mutated CSF1R-induced hereditary diffuse leukoencephalopathy with axonal spheroids
<p><strong>Figure 1:</strong> Family pedigree. The arrow indicates the proband (present patient). Her mother developed a motor disorder at 40 years of age and died at 60 years of age. Her grandparents, father, brothers, sisters, and daughters were not affected.</p> <p><strong>Figure 2: Brain MRI, DWI, DTI, and MRS images. T2/Flair showed multifocal periventricular white matter lesions (A, B, and C), without enhancement (D). DWI shows high-signal intensities in periventricular white matters and corpus callosum (E, F). DTI shows decreased numbers of corpus callosum fibers, while subcortical arcuate fibers are spared (G). MRS shows increased Cho levels, while NAA levels are decreased in the white matter lesions (H, I).</strong></p> <p><strong>Figure 3: </strong>Optic nerves on MRI, showing that bilateral optic nerves are injured (red arrows). </p> <p><strong>Figure 4: </strong>OCT shows that the right peripapillary retinal nerve fiber layer (pRNFL) is atrophic in the temporal quadrant, and the left pRNFL is thinning in the temporal superior quadrants. Green represents pRNFL thickness, which is within normal limits; yellow represents pRNFL thickness, which is below borderline; red represents pRNFL thickness, which is below normal limits.</p> <p><strong>Figure 5:</strong> VEP shows reduced bilateral P100 amplitudes, although P100 latencies are normal in both eyes.</p> <p><strong>Figure 6:</strong> Visual fields in the right eye are partially missing in the upper right, lower right, and lower left quadrants, especially in the lower right quadrant. Visual fields in the left eye are partially missing in the four quadrants, especially in the upper left and lower right quadrants.</p> <p><strong>Figure 7:</strong> Gene analysis of <em>CSF1R</em>. The sequencing result from exon 18 of <em>CSF1R</em> (NM_005211.3) indicates a heterozygous c.2345 G>A (p.782Arg>His) substitution in the patient.</p>
Tomography data for interparticle contact detection analysis in spheroidal granular packings
<p>This collection contains a series of synchrotron XCT scans on a hexagonal close-packed arrangement of soda-glass pellets. The field of view (FOV) diameter is 68.9 mm in diameter, approximately, and the nominal individual pellet diameter is 10 mm. The detector pixel size is 21 microns for all scans. The pellets were arranged in three horizontal lattices (layers). The middle and top lattices were separated by a layer of polyethylene film (cling film), while the bottom and middle layer were fully-contacting. Each file corresponds to a scan of either the bottom contacting or top non-contacting lattice pair. Thus, each filename includes a 'top' and 'bot' identifier. </p> <p>Acquisition parameters (number of projections, exposure time per projection, rotation range and sample position) were varied to achieve different image qualities and are included in 'README.txt'. All but scan A5 were local scans; scan A5 is a full-field scan acquired using the 'half-acquisition' method. </p> <p>Tomographic reconstruction was carried out using filtered back-projection in Savu. After reconstruction, a 3D median filter (kernel size = 2) and an anisotropic diffusion filter (diffusion threshold = 100; iterations = 2) were used to reduce noise.</p> <p>Data was acquired using Beamline I12-JEEP at Diamond Light Source (proposal NT26307-1).</p> <p>Please read README.txt</p> <p>Copyright 2021 Diamond Light Source Ltd. Licensed under the Apache License, Version 2.0.</p>
Gene expression of PFAS exposed human liver spheroids and quality control
<p>Per- and polyfluoroalkyl substances (PFAS) are a wide range of chemicals that are used in a variety of consumer and industrial products leading to direct human exposure. Many PFAS are chemically non-reactive and persistent in the environment, resulting in additional exposure from water, soil, and dietary intake. While some PFAS have documented negative health effects, data on simultaneous exposures to multiple PFAS (PFAS mixtures) are inadequate for making informed decisions for risk assessment. The current study leverages data from previous work in our group using Templated Oligo-Sequencing (TempO-Seq™) for high-throughput transcriptomic analysis of PFAS-exposed primary human liver cell spheroids; herein, we determine the transcriptomic potency of PFAS in mixtures. Gene expression data from single PFAS and mixture exposures of liver cell spheroids were subject to benchmark concentration (BMC) analysis. We used the 25<sup>th</sup> lowest gene BMC as the point of departure to compare the potencies of single PFAS to PFAS mixtures of varying complexity and composure. Specifically, the empirical potency of eight PFAS mixtures were compared to predicted mixture potencies calculated using the principal of concentration addition (i.e., dose addition) in which mixture component potencies are summed by proportion to predict mixture potency. In this study, for most mixtures, empirical mixture potencies were comparable to potencies calculated through concentration addition. This work supports that the effects of PFAS mixtures on gene expression largely follow the concentration addition predicted response and suggests that effects of these individual PFAS in mixtures are not strongly synergistic or antagonistic.</p>
Stellar Density Profiles of Dwarf Spheroidal Galaxies: Posterior Distributions
<p>This archive contains samples from the posterior distributions of our 3-plummer, 1-plummer, 3-steeper and 1-steeper fits for 38 dwarf spheroidal galaxies.</p>
Collected Colorimetric Microscopy (C-Microscopy) Images of Melanocytes and Melanoma 3D Spheroids Irradiated with Different Type of Proton Beam as Used in Proton Radiotherapy
<p>Collected Colorimetric Microscopy (C-Microscopy) images, color calibrated (D65 illuminant), of melanocytes and melanoma 3D spheroids, irradiated with different type of proton beam as used in proton radiotherapy.<br> <br>The data are supplement to:</p> <p>Martyna Durak-Kozica, Ewa Stępień, Jan Swakoń, Benedykt R. Jany, Kamil Kawoń, Damian Wróbel, Sebastian Kusyk, Małgorzata Grzesiak, Katarzyna Knapczyk-Stwora, Andrzej Wróbel, Joanna Chwiejand Paweł Moskal, Short-term response of melanoma spheroids and melanocytes to FLASH proton therapy - colorimetric and FTIR microscopy study, Pol J Med Phys Eng 2024;30(4):263-268 (2024) <a href="https://doi.org/10.2478/pjmpe-2024-0031">https://doi.org/10.2478/pjmpe-2024-0031</a></p> <p> </p> <p><br>HEMA-Spheroids-C-Microscopy.zip - melanocytes 3D spheroids, (C-Microscopy) images, color calibrated (D65 illuminant), image width 435.87 microns</p> <p><br>WM-Spheroids-C-Microscopy.zip - melanoma 3D spheroids, (C-Microscopy) images, color calibrated (D65 illuminant), image width 1089.68 microns</p> <p><br>WM-Spheroids-Texture-C-Microscopy.zip - surface texture of melanoma 3D spheroids, (C-Microscopy) images, color calibrated (D65 illuminant), image width 108.97 microns</p> <p> </p> <p>Proton Beam Radiotherapy Irradiation Conditions:</p> <p>C - Control</p> <p>CC - Control minus 7days</p> <p>LP - conventional proton radiotherapy (CONV) final dose 3Gy (dose rate about 0.140 Gy/s)</p> <p>F - FLASH proton radiotherapy final dose 3Gy (dose rate >60 Gy/s)</p> <p>F20 - FLASH proton radiotherapy final dose 20Gy (dose rate >60 Gy/s)</p> <p>F40 - FLASH proton radiotherapy final dose 40Gy (dose rate >60 Gy/s)</p> <p> </p> <p><br>The details about Colorimetric Microscopy (C-Microscopy) approach could be found in:</p> <p>Benedykt R. Jany, Quantifying Colors at Micrometer Scale by Colorimetric Microscopy (C-Microscopy) Approach, Micron 176, 103557 (2024) <a href="https://doi.org/10.1016/j.micron.2023.103557">https://doi.org/10.1016/j.micron.2023.103557</a></p>
Segmenting cells in a spheroid in 3D using 2D StarDist within TrackMate
<p>3D image of cells in a spheroid, imaged on a confocal microscope, used in a tutorial to demonstrate how to hack TrackMate to segment cells in 3D using the 2D segmentation algorithms it ships.</p> <p>Image by Guillaume Jacquemet.</p> <p>For more details see https://imagej.net/plugins/trackmate/trackmate-stardist#generation-of-3d-labels-by-tracking-2d-labels-using-trackmate</p> <p> </p>
3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction
<p>Datasets for Roche et al (2023), '3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction'.</p>
Limestone spheroid 3D models for: The limestone spheroids of 'Ubeidiya: Intentional imposition of symmetric geometry by early hominins?
<p><span>Spheroids are one of the least understood lithic items yet are one of the most enduring, spanning from the Oldowan to the Middle Palaeolithic. Why and how they were made remains highly debated. We seek to address whether spheroids represent unintentional by-products of percussive tasks or if they were intentionally knapped tools with specific manufacturing goals. We apply novel 3D analysis methods, including spherical harmonics and surface curvature, to 150 limestone spheroids from 'Ubeidiya (c.1.4Ma), presently the earliest Acheulean occurrence outside of Africa, to bring a new perspective to these enigmatic artefacts. We reconstruct the spheroid reduction sequence based on trends in their scar facets and geometry, finding that the spheroid makers at 'Ubeidiya followed a premeditated reduction strategy. During their manufacture, the spheroids do not become smoother, but they become markedly more spherical. They approach an ideal sphere, a feat that likely required a mental template and skilful knapping. Acheulean bifaces are currently thought to represent the earliest evidence of hominins imposing a premeditated, symmetrical shape on stone. With evidence of spheroids occurring before the Acheulean, the intentional production of a sphere-like object now represents the oldest evidence of hominins desiring and achieving intentional geometry and symmetry in stone. </span></p>
Study Evaluating Pantoprazole Sodium Enteric-Coated Spheroid Suspension In Infants With Presumed GERD
ClinicalTrials.gov study NCT00259012. IPD Sharing: Not stated. Countries: 8. Publications: 1.
Limestone spheroid 3D models for: The limestone spheroids of ‘Ubeidiya: Intentional imposition of symmetric geometry by early hominins?
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Models from: Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process
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Gene expression of PFAS exposed human liver spheroids and quality control
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Capability of super-spheroids for modeling PARASOL observations under dusty-sky conditions
<p>Data and Figure for paper 'Capability of super-spheroids for modeling PARASOL observations under dusty-sky conditions'</p>
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.