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729
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ShareScore release 0.7.1
Dataset results
729 results for “Streptococcus”
Group B Streptococcus Response After Probiotic Exposure
ClinicalTrials.gov study NCT04721912. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 1/2, Randomized, Placebo-controlled, Observer-blinded Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Adults 18 To 49 Y
ClinicalTrials.gov study NCT03170609. IPD Sharing: YES. Countries: 1. Publications: 1.
Triphala Tooth Wipes in Reduction of Streptococcus Mutans Colonies
ClinicalTrials.gov study NCT06575335. IPD Sharing: NO. Countries: 1. Publications: 43.
Study of a Group B Streptococcus Vaccine in Pregnant Women Living With HIV and in Pregnant Women Who do Not Have HIV
ClinicalTrials.gov study NCT04596878. IPD Sharing: NO. Countries: 2. Publications: 1.
Immune Response Induced by a Vaccine Against Group B Streptococcus and Safety in Pregnant Women and Their Offsprings
ClinicalTrials.gov study NCT01446289. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Safety and Immunogenicity of the Liquid Formulation of Group B Streptococcus Trivalent Vaccine and of the Lyophilized Formulation of Group B Streptococcus Trivalent Vaccine
ClinicalTrials.gov study NCT02270944. IPD Sharing: YES. Countries: 3. Publications: 1.
Phase I Safety Trial of Streptococcus Pneumoniae Whole Cell Vaccine (SPWCV) + Alum in Healthy Adults
ClinicalTrials.gov study NCT01537185. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety and Immunogenicity of a Group B Streptococcus Vaccine in Non-pregnant Women 18-40 Years of Age.
ClinicalTrials.gov study NCT02459262. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A BOOSTER DOSE OF A GROUP B STREPTOCOCCUS 6 VALENT POLYSACCHARIDE CONJUGATE VACCINE (GBS6) IN HEALTHY ADULTS
ClinicalTrials.gov study NCT04258995. IPD Sharing: YES. Countries: 1. Publications: 1.
Trial to Evaluate the Safety, Tolerability, and Immunogenicity of A Multivalent Group B Streptococcus Vaccine When Administered Concomitantly With Tdap in Healthy Nonpregnant Women
ClinicalTrials.gov study NCT04766086. IPD Sharing: YES. Countries: 1. Publications: 1.
Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Nonpregnant Women And Pregnant Women And Their Infants
ClinicalTrials.gov study NCT03765073. IPD Sharing: YES. Countries: 3. Publications: 2.
Safety and Immunogenicity of a Trivalent Group B Streptococcus Vaccine in Healthy Pregnant Women
ClinicalTrials.gov study NCT02046148. IPD Sharing: YES. Countries: 1. Publications: 1.
Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics
ClinicalTrials.gov study NCT07244991. IPD Sharing: NO. Countries: 1. Publications: 3.
The Efficacy of Probiotics to Reduce Antepartum Group B Streptococcus Colonization.
ClinicalTrials.gov study NCT03696953. IPD Sharing: NO. Countries: 1. Publications: 9.
Dual randomly barcoded transposon sequencing (Dual Tn-seq) data for <em>Streptococcus pneumoniae</em> D39
Open the record for dataset details and reuse information.
Taxonomic reassessment of genomes from a divergent population of Streptococcus suis by average nucleotide identity analysis
Open the record for dataset details and reuse information.
Data from: Oxidative killing of encapsulated and nonencapsulated Streptococcus pneumoniae by lactoperoxidase-generated hypothiocyanite
<p class="CxSpFirst"><i>Streptococcus pneumoniae</i> (Pneumococcus) infections affect millions of people worldwide, cause serious mortality and represent a major economic burden. Despite recent successes due to pneumococcal vaccination and antibiotic use, Pneumococcus remains a significant medical problem. Airway epithelial cells, the primary responders to pneumococcal infection, orchestrate an extracellular antimicrobial system consisting of lactoperoxidase (LPO), thiocyanate anion and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). LPO oxidizes thiocyanate using H<sub>2</sub>O<sub>2</sub> into the final product hypothiocyanite that has antimicrobial effects against a wide range of microorganisms. However, hypothiocyanite's effect on Pneumococcus has never been studied. Our aim was to determine whether hypothiocyanite can kill <i>S. pneumoniae.</i> Bactericidal activity was measured in a cell-free <i>in vitro </i>system by determining the number of surviving pneumococci via colony forming units on agar plates, while bacteriostatic activity was assessed by measuring optical density of bacteria in liquid cultures. Our results indicate that hypothiocyanite<sup> </sup>generated by LPO exerted robust killing of both encapsulated and nonencapsulated pneumococcal strains. Killing of <i>S. pneumoniae</i> by a commercially available hypothiocyanite-generating product was even more pronounced than that achieved with laboratory reagents. Catalase, an H<sub>2</sub>O<sub>2</sub> scavenger, inhibited killing of pneumococcal by hypothiocyanite under all circumstances. Furthermore, the presence of the bacterial capsule or lytA-dependent autolysis had no effect on hypothiocyanite-mediated killing of pneumococci. On the contrary, a pneumococcal mutant deficient in pyruvate oxidase (main bacterial H<sub>2</sub>O<sub>2</sub> source) had enhanced susceptibility to hypothiocyanite compared o its wild-type strain. Overall, results shown here indicate that numerous pneumococcal strains are susceptible to LPO-generated hypothiocyanite.</p>
Isolation and identification of Streptococcus suis from sick pigs in Bali, Indonesia
<p><b>Objective </b></p> <p><i>Streptococcus suis</i> (<i>S. suis</i>) is a causative agent for various syndromes in pigs. It can be transmitted to humans with typical symptoms of meningitis and death. Although human infections have been confirmed at Bali Referral Hospital, Indonesia, since 2014, the bacteria have not been isolated from pigs. Here, we provide confirmation of the presence of the bacteria in sick pigs in the province.</p> <p><b>Results</b></p> <p><i>S. suis</i> was confirmed in 8 of 30 cases. <a name="_Hlk21025505">The final confirmation was made using PCR and sequencing of the glutamate dehydrogenase (GDH) and recombination/repair protein (recN) gene fragments. Upon PCR serotyping, two were confirmed to be serotype 2 or 1/2</a>. Prominent histopathological lesions of confirmed cases were meningitis, endocarditis, pericarditis, bronchopneumonia, enteritis and glomerulonephritis. The dominant inflammatory cells were neutrophils and macrophages. Further research is needed to understand the risk factors for human infection. Community awareness on the risk of contracting <i>S. suis</i> and vaccine development are needed to prevent human infections.</p>
Data from: Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae
Streptococcus pneumoniae is common nasopharyngeal commensal bacterium and important human pathogen. Vaccines against a subset of pneumococcal antigenic diversity have reduced rates of disease, without changing the frequency of asymptomatic carriage, through altering the bacterial population structure. These changes can be studied in detail through using genome sequencing to characterise systematically-sampled collections of carried S. pneumoniae. This dataset consists of 616 annotated draft genomes of isolates collected from children during routine visits to primary care physicians in Massachusetts between 2001, shortly after the seven valent polysaccharide conjugate vaccine was introduced, and 2007. Also made available are a core genome alignment and phylogeny describing the overall population structure, clusters of orthologous protein sequences, software for inferring serotype from Illumina reads, and whole genome alignments for the analysis of closely-related sets of pneumococci. These data can be used to study both bacterial evolution and the epidemiology of a pathogen population under selection from vaccine-induced immunity.
Streptococcus Pneumoniae ST556 Vs Mycoplasma Pneumoniae M129 genome by Blastn analysis
<p><strong>Introduction:</strong> The overlap between Streptococcus pneumoniae and Mycoplasma pneumoniae genome was studied by Blastn analysis. Mycoplasma is an intracellular pathogen causing pneumonia with staccato cough, predominantly handled by T cell immunity. </p><p><strong>Methods:</strong> Through the NCBI website, the overlap of genome sequences of Streptococcus pneumoniae Taiwan (PT 306), and mycoplasma pneumoniae were studied using Blastn. The accession number for the Streptococcus pneumoniae ST556 was CP003357, and the Mycoplasma pneumoniae strain M129 was U00089, respectively. DNA alignments and nucleotide overlapping alignment sequences were studied.</p><p><strong>Results:</strong> There were significant overlaps between the genome sequences of these two organisms by blastn. The overlapping sequences and dot analysis are shown in the files attached in this accompanying document. The overlapping nucleotides involved with high significance (expect values = 0.0).</p><p><strong>Conclusion:</strong> There are overlaps in genome sequences between Streptococcus pneumoniae and mycoplasma genomes. Further studies are required to study the significance of the COVID-19 context and the recent outbreak of mycoplasma in the community across various countries. The overlap can throw some ideas of the use of the potential of streptococcus pneumoniae vaccines for prevention. If not a prevention Streptococcus pneumonia vaccinations can facilitate a deceleration in the spread of mycoplasma infections.</p><p> </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.