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784 results for “Tregs”
Clinical Relationship Between Vitamin D-mediated Th17 and Treg Cells and Parkinson's Disease
ClinicalTrials.gov study NCT06539260. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of High Cut-off (HCO) Hemodialysis on Central Memory CD4+ T and Treg Cells in Patients With End-stage Kidney Disease
ClinicalTrials.gov study NCT01103076. IPD Sharing: Not stated. Countries: 1. Publications: 2.
T1DM Immunotherapy Using Polyclonal Tregs + IL-2
ClinicalTrials.gov study NCT02772679. IPD Sharing: NO. Countries: 1. Publications: 35.
Treg Effector Function and Th2/Treg Ratio in Allergic Conjunctivitis: Effect of Desensitization Therapy
ClinicalTrials.gov study NCT07171307. IPD Sharing: NO. Countries: 1. Publications: 2.
TREg Activation in the Treatment of the PELADE (Alopecia Areata)
ClinicalTrials.gov study NCT02557074. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treg Adoptive Therapy for Subclinical Inflammation in Kidney Transplantation
ClinicalTrials.gov study NCT02088931. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The Effects of Nanocurcumin on Treg Cells and Th17 Cells Responses in Ankylosing Spondylitis Patients
ClinicalTrials.gov study NCT03140657. IPD Sharing: NO. Countries: 1. Publications: 7.
Safety Study and Therapeutic Effects of Umbilical Cord Blood Treg on Autoimmune Diabetes
ClinicalTrials.gov study NCT02932826. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Combination With Treg Levels and CMR to Assess the Severity and Prognosis of Reperfusion Injury After PPCI in STEMI Patients
ClinicalTrials.gov study NCT03939338. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treg Immunotherapy in Crohn's Disease
ClinicalTrials.gov study NCT03185000. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism
<p>Human plasma metabolomics dataset generated from controlled human hookworm infection study. <br><br><span>Infecting humans with controlled doses of helminths, such as human hookworm (termed hookworm therapy), is proposed to prevent or treat various intestinal and extraintestinal disease. However, full-scale clinical trials examining hookworm therapy are limited by the inability to scale-up the production of hookworm larvae to infect sufficient numbers of patients. With the aim of overcoming this challenge, this study infected four healthy individuals with hookworm larvae that had been reanimated from cryopreserved eggs, to examine their viability and immunogenicity. We</span><span> demonstrate that reanimated cryopreserved hookworm larvae establish a viable hookworm infection and elicit a similar immune response to larvae cultured from fresh stool. Furthermore, </span><span>a refined understanding of the therapeutic mechanisms of hookworm is imperative to determine which diseases to target with hookworm therapy. To investigate potential therapeutic mechanisms, this study infected 13 healthy individuals with hookworm and assessed changes in the immune cells, microbiome, and metabolome.</span><span> <span>We identified potential immunoregulatory mechanisms by which hookworm may provide a beneficial </span></span><span>effect on its host, including increased expression of CTLA-4 on regulatory T cells (Tregs) and upregulation of tryptophan metabolism. In summary, our findings demonstrate the feasibility of full-scale clinical trials examining hookworm therapy by minimising the reliance on human donors and optimising the culturing process, thereby enabling viable hookworm larvae to be mass-produced and enabling on-demand inoculation of patients. Furthermore, this study provides insights into the complex interactions between helminths and their host, which could inform the development of novel therapeutic strategies.</span></p>
Tregs CD25 CXCL9 in Vitiligo
ClinicalTrials.gov study NCT05569096. IPD Sharing: Not stated. Countries: 0. Publications: 6.
The Effect of Oral Nanocurcumin as an Adjuvant Therapy for Anogenital Warts: Evaluation of Clinical Improvement, NFĸB, IFN-γ, and FOXP3+TReg From Lesions Tissue
ClinicalTrials.gov study NCT06281353. IPD Sharing: NO. Countries: 1. Publications: 0.
IS-free Treg HaploHCT
ClinicalTrials.gov study NCT04678401. IPD Sharing: YES. Countries: 1. Publications: 0.
Treg Therapy in Subclinical Inflammation in Kidney Transplantation
ClinicalTrials.gov study NCT02711826. IPD Sharing: YES. Countries: 1. Publications: 0.
Treg Modulation With CD28 and IL-6 Receptor Antagonists
ClinicalTrials.gov study NCT04066114. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Tregs for the Treatment of Acute Respiratory Distress Syndrome (ARDS) Associated With COVID-19 (regARDS)
ClinicalTrials.gov study NCT05027815. IPD Sharing: NO. Countries: 1. Publications: 0.
Liver Transplantation With Tregs at UCSF
ClinicalTrials.gov study NCT03654040. IPD Sharing: YES. Countries: 1. Publications: 0.
Adoptive TReg Cell for Suppression of aGVHD After UCB HSCT for Heme Malignancies
ClinicalTrials.gov study NCT02991898. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autologous Polyclonal Tregs for Lupus
ClinicalTrials.gov study NCT02428309. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.