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107 results for “Trypanosoma brucei”
IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
<p>In the skin, <em>Trypanosoma brucei </em>colonises the subcutaneous white adipose tissue (WAT) and harbours a pool of parasites competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune system is likely to drive adipose tissue wasting and weight loss observed in cattle and humans infected with <em>T. brucei</em>. However, mechanistically, this process is not fully understood. Here, using several complementary approaches including mass cytometry by time of flight, bulk and single cell transcriptomics, we found that <em>T. brucei</em> infection drives a local expansion of several IL-17A-producing cells in the murine WAT, including T<sub>H</sub>17 and Vg6<sup>+</sup> T cells. We also found that global IL-17 deficiency, or mice lacking IL-17 receptor expression specifically on adipocytes, were protected from infection-induced WAT wasting and weight loss. Unexpectedly, we found that abrogation of IL-17 signalling on adipocytes results in higher burden of extravascular parasites in the WAT. Taken together, our study highlights the central role of IL-17 signalling on adipocytes in controlling WAT responses to infection, suggesting that adipocytes are a critical coordinator of the tissue immune response to <em>T. brucei</em> infection. </p>
Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in
ClinicalTrials.gov study NCT00906880. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Impact of the Ebola outbreak on Trypanosoma brucei gambiense infection medical activities in coastal Guinea, 2014-2015: a retrospective analysis from the Guinean national Human African Trypanosomiasis control program
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Data from: Genetic diversity and population structure of Trypanosoma brucei in Uganda: implications for the epidemiology of sleeping sickness and Nagana
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Trypanosoma brucei L-threonine dehydrogenase high resolution diffraction images.
<p>Diffraction images obtained in the high resolution pass for apo-L-threonine dehydrogenase from <em>T. brucei</em>. </p>
Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of Trypanosoma brucei
<p>Raw ChIP-chip and MFA-seq data from the paper listed above.</p>
Data from: Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation
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Identification of mRNAs associated with the protein complex ZC3H41/Z41AP (Tb927.11.1980/Tb927.7.7460) in Trypanosoma brucei
GEO Series GSE212920. Trypanosoma brucei brucei. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei
GEO Series GSE18049. Trypanosoma brucei brucei TREU927. 15 samples. Type: Expression profiling by genome tiling array.
Mono-allelic epigenetic regulation of bi-directional polycistronic transcription initiation by RNA Polymerase II in Trypanosoma brucei.
GEO Series GSE273238. Trypanosoma brucei. 9 samples. Type: Expression profiling by high throughput sequencing.
Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection
GEO Series GSE200642. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host
GEO Series GSE46388. Trypanosoma brucei brucei. 9 samples. Type: Expression profiling by high throughput sequencing.
Dynamic mRNA Expression analysis of cells undergoing synchronous life-cycle differentiation in Trypanosoma brucei
GEO Series GSE17026. Trypanosoma brucei. 25 samples. Type: Expression profiling by array.
Characterization of the regulatory programs governed by ELAV-like proteins in Trypanosoma brucei
GEO Series GSE46162. Trypanosoma brucei brucei TREU927; Trypanosoma brucei. 24 samples. Type: Expression profiling by high throughput sequencing; Expression profiling by array.
Effect of the depletion of PuREBP1 (Tb927.4.4550) on the transcriptome of Trypanosoma brucei [RNAi]
GEO Series GSE145468. Trypanosoma brucei brucei. 4 samples. Type: Expression profiling by high throughput sequencing.
Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections.
GEO Series GSE114843. Trypanosoma brucei brucei. 20 samples. Type: Other.
iCLIP and NGS to map protein-RNA interactions for U1-snRNP proteins in Trypanosoma brucei
GEO Series GSE43848. Trypanosoma brucei. 5 samples. Type: Other.
Comparative RNAseq analysis of Trypanosoma brucei and T. congolense
GEO Series GSE165290. Trypanosoma congolense; Trypanosoma brucei. 16 samples. Type: Expression profiling by high throughput sequencing.
Life stage specific poly(A) site selection regulated by Trypanosoma brucei DRBD18
GEO Series GSE255758. Trypanosoma brucei. 4 samples. Type: Expression profiling by high throughput sequencing.
RIP-Seq analysis of Trypanosoma brucei ELAV-like protein Tb927.8.6650
GEO Series GSE46160. Trypanosoma brucei. 2 samples. Type: Expression profiling by high throughput sequencing.
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