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40 results for “Tyrosinase”
Observation of the Effect of Chemotherapy Combined With Tyrosinase Inhibitor on the Reactivation of CMV and EBV in Patients With Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT03331211. IPD Sharing: NO. Countries: 1. Publications: 1.
Molecular simulation and tyrosinase inhibitory studies of arbutin-6′-undecenoate
<p>Arbutin is frequently used as an inhibitor of tyrosinase, a key enzyme in the biosynthesis of melanin. Tyrosinase inhibitors are highly sought after by the pharmaceutical and cosmetic industries. Given the increasing interest in such products, we performed a one-step synthesis of acylated arbutin by protease-catalysed transesterification using undecylenic acid ester as acyl donor. We simulated the docking of tyrosinase with the product using AutoDock Vina and identified its activity as a tyrosinase inhibitor by in vitro assay against mushroom tyrosinase. We successfully synthesized arbutin-6′-undecenoate by the formation of an ester linkage between the carboxyl residue (C1″) of undecylenic acid ester and the C6′ glucose moiety of arbutin. Results showed that the binding affinity of arbutin-6′-undecenoate with tyrosinase was higher than that of arbutin. In addition, arbutin-6′-undecenoate inhibits tyrosinase activity effectively (IC50 = 0.16 mM). The results of this study strongly suggest that arbutin-6′-undecenoate is a promising candidate as tyrosinase inhibitor.</p>
Figure 3 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 3 The interaction of hydrogen bonds between the target protein of the tyrosinase with kojic acid. a: docking conformation kojic acid to tyrosinase, b: 3D interaction visualization of tyrosinase amino acid residues with kojic acid, c: 2D interaction visualization of tyrosinase amino acid residues with kojic acid.
Figure 5 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 5 TLC-chromatogram of Moringa Leaves extract at UV 254 nm (A) and UV 366 nm (B). Quercetin standard 100, 200, 400, 800, 1600 and 3200 ng (1–6); Moringa Leaves Maceration extract (7); reflux extract (8), soxhlation extract (9); quercetin standard 800 ng (10–11); UV spectrum of spot with Rf 0.4 from quercetin standard (C); UV spectrum of spot with Rf 0.4 from maceration extract of Moringa Leaves (D); UV spectrum of spot with Rf 0.4 from soxhlation extract of Moringa Leaves (E).
Figure 1 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 1 Redocking visualization between tyrosinase enzyme and native ligand. 1: The structure of the tyrosinase enzyme (PDB ID: 2Y9X), 2a: tyrosinase enzyme structure without native ligand, 2b: native ligand (tropolone) structure, 3a: redocking conformation, 3b: 3D interaction of amino acid residues from tyrosinase enzyme with native ligand, 3c: 2D interaction of amino acid residues from tyrosinase enzyme with native ligand.
Figure 4 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 4 The interaction of hydrogen bonds between the target protein of the tyrosinase with quercetin. a: docking conformation between quercetin and tyrosinase, b: 3D interaction visualization of tyrosinase amino acid residues with quercetin, c: 2D interaction visualization of tyrosinase amino acid residues with quercetin.
Figure 6 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 6 The regression curve of the relationship between AUC and series concentration of quercetin standard.
Fig. 3 in Neuropyrones A-E, five undescribed α-pyrone derivatives with tyrosinase inhibitory activity from the endophytic fungus Neurospora dictyophora WZ-497
Fig. 3. The inhibitory effects of 1–5 on tyrosinase.
Fig. 2. Key 1 H– 1 H in Neuropyrones A-E, five undescribed α-pyrone derivatives with tyrosinase inhibitory activity from the endophytic fungus Neurospora dictyophora WZ-497
Fig. 2. Key 1 H– 1 H COSY and HMBC correlations of neuropyrones A–E (1–5).
Fig. 1 in Neuropyrones A-E, five undescribed α-pyrone derivatives with tyrosinase inhibitory activity from the endophytic fungus Neurospora dictyophora WZ-497
Fig. 1. Chemical structures of neuropyrones A–E (1–5).
Molecular simulation and tyrosinase inhibitory studies of arbutin-6′-undecenoate
Open the record for dataset details and reuse information.
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
GEO Series GSE226827. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Small molecule ML233 is a direct inhibitor of tyrosinase function and reduces melanoma proliferation
GEO Series GSE268076. Danio rerio. 24 samples. Type: Expression profiling by high throughput sequencing.
Figure 7 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 7 Dopachrome spectrum using spectrophotometry UV-VIS.
Figure 2 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 2 2D Chemical structure of quercetin (a), 3D chemical structure of quercetin (b).
Figure 9 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 9 Tyrosinase inhibition (%) curve of moringa leaves extract.
Figure 8 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 8 Tyrosinase inhibition (%) curve of kojic acid.
Vaccination of AJCC Stage IIB, IIC, III and IV Melanoma Patients With Human and Mouse Tyrosinase DNA Vaccines
ClinicalTrials.gov study NCT00698100. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells
GEO Series GSE273734. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome Editing with Tyrosinase gRNA
GEO Series GSE225711. Mus musculus. 3 samples. Type: Other.
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