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opennotspecifiedAug 2020View details →

Fig. 2 in Identification and functional characterization of two acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) genes from forage sorghum (Sorghum bicolor) embryo

Fig. 2. Sequence alignment of SbDGAT1-1 (XP_002439419) and SbDGAT1-2 (XP_021304830) deduced amino acid sequences with biochemically characterized AtDGAT1 (CAB45373). Putative N-terminal region is highlighted with blue colour. Conserved sequence domains are boxed, the acyl-CoA binding site (Jako et al., 2001; Ayme et al., 2015), active site (Jako et al., 2001), typical SnRK1 protein kinase binding motif (Zou et al., 1999; Xu et al., 2008), thiolase acyl-enzyme intermediate binding motif (Zou et al., 1999; Xu et al., 2008), FA binding protein signature (Guo et al., 2017), DAG-binding site (Guo et al., 2017) and ER retrieval motif (Aznar-Moreno et al., 2015). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

opennotspecifiedAug 2020View details →

Fig. 1. Phylogenetic relationship between SbDGAT1-1 and SbDGAT1-2 with other DGAT1 and DGAT2 in Identification and functional characterization of two acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) genes from forage sorghum (Sorghum bicolor) embryo

Fig. 1. Phylogenetic relationship between SbDGAT1-1 and SbDGAT1-2 with other DGAT1 and DGAT2 protein sequences. Phylogenetic tree was constructed using maximum likelihood method (Tamura et al., 2011; Hall, 2013) in Molecular Evolutionary Genetics Analysis (MEGA) 7.0 tool (Kumar et al., 2016). Bootstrap values are mentioned in the branches. GenBank accession numbers are indicated with species names of the DGAT proteins.

opennotspecifiedMar 2020View details →

Fig. 3 in Linaburiosides A-D, acylated iridoid glucosides from Linaria buriatica

Fig. 3. Application of (A) the PGME method to 7-deoxyiridolactonic acid (6) and (B) modified Mosher's method to 5d and 1b.

opennotspecifiedMar 2020View details →

Fig. 2 in Linaburiosides A-D, acylated iridoid glucosides from Linaria buriatica

Fig. 2. (A) Selected 1H–1H COSY and HMBC correlations and (B) selected NOESY correlations for 7-deoxyiridolactonic acid (6) and linaburioside A (1).

opennotspecifiedMar 2020View details →

Fig. 1 in Linaburiosides A-D, acylated iridoid glucosides from Linaria buriatica

Fig. 1. Structures of linaburiosides A−D (1–4), iridolinarin C (5), and 7-deoxyiridolactonic acid (6).

ClinicalTrials.gov32/100

LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study

ClinicalTrials.gov study NCT06217588. IPD Sharing: NO. Countries: 1. Publications: 1.

closedIPD-NOFeb 2026View details →

ClinicalTrials.gov32/100

Acylated Ghrelin Response to Acute Exercise in Obesity

ClinicalTrials.gov study NCT00486161. IPD Sharing: Not stated. Countries: 1. Publications: 15.

restrictedIPD-UNDECIDEDFeb 2026View details →

Figure 8 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543

Figure 8 Structures of compounds 7 (octanoyl derivative), 9 (myristoyl derivative), and 14 (dichloroacetyl derivative).

Scheme 1 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543

Scheme 1 Reagents and conditions: (a) dry Py, (C6H5)3COCl, –5 °C, 6 h, (70%; Rf = 0.52); (b) dry Py, various acyl halides (3–14), 0 °C to rt, DMAP, 6 h.

Figure 5 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543

Figure 5 Percentage zone of mycelial growth inhibition for compounds 3 and 11 against A. niger (A and B, respectively). DMSO represents the negative control, whereas nystatin is the positive control.

Figure 2 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543

Figure 2 Percentage of inhibition observed for A) B. subtilis by compounds 7, 9, and 8; B) E. coli by compounds 2, 4, and 9; C) S. abony by compounds 7, 9, and 14; and D) S. aureus by compounds 7, 9, and 14. DMSO was the negative control, whereas azithromycin represented the positive control.

Figure 7 from: Bulbul MZH, Chowdhury TS, Misbah MMH, Ferdous J, Dey S, Hasan I, Fujii Y, Ozeki Y, Kawsar SMA (2021) Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents. Pharmacia 68(1): 23-34. https://doi.org/10.3897/pharmacia.68.e56543

Figure 7 Percentage growth inhibition observed for various concentrations of compound 9. Right figure 96-well flat-bottom experiment.

opencc-zeroDec 2012View details →

dryad28/100

Data from: Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins

The interaction of dietary fats and carbohydrates on liver mitochondria were examined in male FBNF1 rats fed 20 different low-fat, isocaloric diets. Animal growth rates and mitochondrial respiratory parameters were essentially unaffected, but mass spectrometry-based, mitochondrial lipidomics profiling revealed increased levels of cardiolipins (CLs), a family of phospholipids essential for mitochondrial structure and function, in rats fed saturated or trans fat-based diets with a high glycemic index. These mitochondria showed elevated monolysocardiolipins (a CL precursor/product of CL degradation), elevated ratio of trans PC (18:1/18:1) to cis PC (18:1/18:1) (a marker of thiyl radical stress), and decreased ubiquinone Q9 -- the latter two of which imply a low-grade mitochondrial redox abnormality. Extended analysis demonstrated: (i) dietary fats and, to a lesser extent, carbohydrates induce changes in the relative abundance of specific CL species; (ii) Fatty acid (FA) incorporation into mature CLs undergoes both positive (>400-fold) and negative (2.5-fold) regulation; and, (iii) dietary lipid abundance and incorporation of FAs into both the CL pool and specific mature tetra-acyl CLs are inversely related, suggesting previously unobserved compensatory regulation. This study reveals previously unobserved complexity/regulation of the central lipid in mitochondrial metabolism.

Fig. 1. Structures for compounds 1–6 in Long-chain fatty acid acylated derivatives of isoflavone glycosides from the rhizomes of Iris domestica

Fig. 1. Structures for compounds 1–6.

Fig. 2 in Long-chain fatty acid acylated derivatives of isoflavone glycosides from the rhizomes of Iris domestica

Fig. 2. The key HMBC correlations () for compounds 1–6.

Fig. 3 in Acylated saponins and flavonoid glycosides from the fruits of Stewartia koreana

Fig. 3. Key HMBC (from H to C) correlation for compounds 4–6.

Fig. 1 in Acylated saponins and flavonoid glycosides from the fruits of Stewartia koreana

Fig. 1. Chemical structures of isolated compounds 1–6 from the dried fruits of Stewartia koreana.

opennotspecifiedSep 2022View details →

Fig. 2. Key 1H–1H in Fatty acid acylated flavonol glycosides from the seeds of Nephelium lappaceum and their nitric oxide suppression activity

Fig. 2. Key 1H–1H COSY and HMBC correlations of compounds 1–5.

opennotspecifiedSep 2022View details →

Fig. 1 in Fatty acid acylated flavonol glycosides from the seeds of Nephelium lappaceum and their nitric oxide suppression activity

Fig. 1. Structures of all isolated compounds from the seeds of N. lappaceum.