Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,046
datasets available to search
ShareScore release 0.9.0
Dataset results
1,046 results for “anti-inflammatory”
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
<p class="MsoNormal"><span><strong>Background:</strong> Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. </span>A neuroprotective compound, ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup>also known as Semax has <span>shown neuroprotective and anti-inflammatory properties. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> <span>also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI.</p> <p><span><strong>Method: </strong>We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup><span>was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. </span>The preparations tissue sample were fixed in formalin and examined for immunohistochemistry<span>. Quantitative measurement of anti-inflammatory cytokine (</span>IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies.</p> <p> </p> <p><strong>Result:</strong> Rats with mild SCI that were given ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group.</p> <p> </p> <p><strong>Conclusion: </strong>Administration of ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.</p>
Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00595114. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Variability in Response to Non-steroidal Anti-inflammatory Drugs
ClinicalTrials.gov study NCT02502006. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy Volunteers
ClinicalTrials.gov study NCT00339833. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Defining the Anti-inflammatory Role of Lipoic Acid in Multiple Sclerosis
ClinicalTrials.gov study NCT00997438. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
ClinicalTrials.gov study NCT00476593. IPD Sharing: NO. Countries: 1. Publications: 1.
Insulin-Sensitizing Anti-Inflammatory Small Molecule for Investigative Treatment of Dementia
ClinicalTrials.gov study NCT05227820. IPD Sharing: Not stated. Countries: 1. Publications: 36.
Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances
ClinicalTrials.gov study NCT02272725. IPD Sharing: NO. Countries: 1. Publications: 1.
Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis
ClinicalTrials.gov study NCT03584724. IPD Sharing: NO. Countries: 1. Publications: 4.
Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
ClinicalTrials.gov study NCT02633358. IPD Sharing: NO. Countries: 1. Publications: 8.
Anti-inflammatory Effects of Colchicine in PCI
ClinicalTrials.gov study NCT01709981. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Withania Somnifera: an Immunomodulator and Anti-inflammatory Agent for Schizophrenia
ClinicalTrials.gov study NCT01793935. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Canakinumab in the Treatment of Acute Gout Flares and Prevention of New Flares in Patients Unable to Use Non-steroidal Anti-inflammatory Drugs (NSAIDs) and/or Colchicines Including a 12 Week Extension
ClinicalTrials.gov study NCT01080131. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Anti-inflammatory Therapy With Anakinra in Newly Diagnosed Type 1 Diabetes
ClinicalTrials.gov study NCT00645840. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS)
ClinicalTrials.gov study NCT01171794. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trial to Assess the Anti-inflammatory Effects of Roflumilast in Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT01509677. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
ClinicalTrials.gov study NCT00984815. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
ClinicalTrials.gov study NCT02998918. IPD Sharing: NO. Countries: 1. Publications: 24.
The Anti-inflammatory Effect of Prophylactic Macrolides on Children With Chronic Lung Disease
ClinicalTrials.gov study NCT02544984. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or H
ClinicalTrials.gov study NCT03304379. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.