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2,408 results for “atrial fibrillation”
Quality of life among patients with atrial fibrillation
<p><strong><span>Background</span></strong></p> <p><span>Patients with atrial fibrillation (AF) have significantly lower health-related quality of life (HRQoL) compared to the general population and patients with other heart diseases. The research emphasis on the influence of AF symptoms on HRQoL overshadows the role of individual characteristics. To address this gap, this study's purpose was to </span><span>test an incremental predictive model </span><span>for AF-related HRQoL following an adapted HRQoL conceptual model that incorporates both symptoms and individual characteristics.</span></p> <p><strong><span>Methods</span></strong></p> <p><span>Patients attending an AF specialty clinic were invited to complete an online survey. Hierarchical regression analyses were conducted to examine whether individual characteristics (overall mental health, perceived stress, sex, age, AF knowledge, household and recreational physical activity) incremented prediction of HRQoL and AF treatment satisfaction beyond AF symptom recency and overall health. </span></p> <p><strong><span>Results</span></strong></p> <p>Of 196 participants (mean age 65.3 years), 63% were male and 90% were Caucasian. Most reported 'excellent' or 'good' overall and mental health, had high overall AF knowledge scores, had <span>low </span>perceived stress scores, and had high household and recreation physical activity. The mean overall AF Effect On Quality-Of-Life Questionnaire (<span>AFEQT) and AF treatment satisfaction scores were 70.62 and 73.84, respectively. Recency of </span><span>AF symptoms and overall health accounted for 29.6% of the variance in overall HRQoL and 20.2% of the variance in AF treatment satisfaction. Individual characteristics explained an additional 13.6% of the variance in overall HRQoL and 7.6% of the variance in AF treatment satisfaction. Perceived stress and household physical activity were the largest contributors to overall HRQoL, whereas age and AF knowledge made significant contributions to AF treatment satisfaction.</span></p> <p><strong><span>Conclusions</span></strong></p> <p><span>Along with AF symptoms and overall health, individual characteristics are important predictors of HRQoL and AF treatment satisfaction in AF patients. In particular, perceived stress and household physical activity </span><span>could further be targeted as potential areas to improve HRQoL. </span></p>
Genome-wide association results: strictly-defined atrial fibrillation vs. all controls
<p>Genome-wide association study summary-level results from an analysis of broadly-defined atrial fibrillation vs controls. The columns are as follows:</p> <ul> <li>SNP: rs identifier</li> <li>CHR: chromosome, build hg19</li> <li>BP: basepair position, build hg19</li> <li>GENPOS: genetic position</li> <li>ALLELE1: tested (first) allele</li> <li>ALLELE0: other allele</li> <li>A1FREQ: frequency of ALLELE1</li> <li>F_MISS: missingness at that SNP</li> <li>BETA: beta (effect size) from the linear mixed model in BOLT-LMM</li> <li>SE: standard error from the linear mixed model in BOLT-LMM</li> <li>P_BOLT_LMM_INF: p-value from the linear mixed model (infinitesimal model) in BOLT-LMM</li> </ul>
Genome-wide association results: broadly-defined atrial fibrillation vs. all controls
<p>Genome-wide association study summary-level results from an analysis of broadly-defined atrial fibrillation vs controls. The columns are as follows:</p> <ul> <li>SNP: rs identifier</li> <li>CHR: chromosome, build hg19</li> <li>BP: basepair position, build hg19</li> <li>GENPOS: genetic position</li> <li>ALLELE1: tested (first) allele</li> <li>ALLELE0: other allele</li> <li>A1FREQ: frequency of ALLELE1</li> <li>F_MISS: missingness at that SNP</li> <li>BETA: beta (effect size) from the linear mixed model in BOLT-LMM</li> <li>SE: standard error from the linear mixed model in BOLT-LMM</li> <li>P_BOLT_LMM_INF: p-value from the linear mixed model (infinitesimal model) in BOLT-LMM</li> </ul> <p> </p>
Raw Data for the article: Atrial fibrillation ablation improves late survival after concomitant cardiac surgery
<p><strong>Objective: </strong>Preoperative atrial fibrillation (AF) increases risk of stroke, heart failure, and all-cause mortality after cardiac surgery. Despite encouraging results and guideline recommendations, surgical ablation (SA) for AF concomitant with other heart surgery remains low. In the current study we aimed to address the long-term mortality after SA concomitant with cardiac surgery.</p> <p><strong>Methods: </strong>This report pertains to the HEart surgery In atrial fibrillation and Supraventricular Tachycardia (HEIST) registry. We identified 20,765 adult patients (62% male) with preoperative AF who underwent conventional sternotomy heart surgery between 2010 and 2021 in 8 tertiary centers in Poland, Netherlands, and Italy. We used Cox proportional hazards models for computations and propensity score matching to minimize differences in baseline characteristics.</p> <p><strong>Results: </strong>Of included patients, 2755 (13.4%) underwent SA for AF. The highest rates of SA were observed for mitral interventions (mitral valve repair or replacement and tricuspid intervention, 25.2%), lowest for isolated coronary artery bypass grafting (6.2%). Patients in the SA group were younger (mean age 64.5 ± 9.0 years vs 68.7 ± 16.0 years; P < .001) and lower risk (mean European System for Cardiac Operative Risk Evaluation [EuroSCORE] II, 4.1 vs 5.7; P < .001). During the 11-year study period, there was a mortality reduction associated with SA (hazard ratio, 0.57; 95% CI, 0.52-0.62; P < .001). After propensity matching, 2750 pairs with similar baseline characteristics were identified. SA was associated with 16% mortality decline (hazard ratio, 0.84; 95% CI, 0.75-0.94; P = .003).</p> <p><strong>Conclusions: </strong>In this multicenter, retrospective, propensity matched study, SA concomitant with other cardiac surgery was associated with improved long-term survival regardless of baseline surgical risk.</p>
Raw Data for the article: Clinical Insights to Complete and Incomplete Surgical Revascularization in Atrial Fibrillation and Multivessel Coronary Disease
<p><strong>Objectives: </strong>Although endorsed by international guidelines, complete revascularization (CR) with Coronary Artery Bypass Grafting (CABG) remains underused. In higher-risk patients such as those with pre-operative atrial fibrillation (AF), the effects of CR are not well studied.</p> <p><strong>Methods: </strong>We analyzed patients' data from the HEIST (HEart surgery In AF and Supraventricular Tachycardia) registry. Between 2012 and 2020 we identified 4770 patients with pre-operative AF and multivessel coronary artery disease who underwent isolated CABG. We divided the cohort according to the completeness of the revascularization and used propensity score matching (PSM) to minimize differences between baseline characteristics. The primary endpoint was all-cause mortality.</p> <p><strong>Results: </strong>Median follow-up was 4.7 years [interquartile range (IQR) 2.3-6.9]. PSM resulted in 1,009 pairs of complete and incomplete revascularization. Number of distal anastomoses varied, accounting for 3.0 + -0.6 vs. 1.7 + -0.6, respectively. Although early (< 24 h) and 30-day post-operative mortalities were not statistically different between non-CR and CR patients [Odds Ratio (OR) and 95% Confidence Intervals (CIs): 1.34 (0.46-3.86); <em>P</em> = 0.593, Hazard Ratio (HR) and 95% CIs: 0.88 (0.59-1.32); <em>P</em> = 0.542, respectively] the long term mortality was nearly 20% lower in the CR cohort [HR (95% CIs) 0.83 (0.71-0.96); <em>P</em> = 0.011]. This benefit was sustained throughout subgroup analyses, yet most accentuated in low-risk patients (younger i.e., < 70 year old, with a EuroSCORE II < 2%, non-diabetic) and when off-pump CABG was performed.</p> <p><strong>Conclusion: </strong>Complete revascularization in patients with pre-operative AF is safe and associated with improved survival. Particular survival benefit with CR was observed in low-risk patients undergoing off-pump CABG.</p>
Rhythm control and cardiovascular or cerebrovascular out-comes in patients with atrial fibrillation: A study of the CODE-AF registry
<p><strong>SUPPLEMENTARY MATERIAL</strong></p> <p> </p> <p><strong><em>Rhythm control and cardiovascular or cerebrovascular outcomes in patients with atrial fibrillation: A study of the CODE-AF registry</em></strong></p> <p> </p> <p>Ho Gi Chung, MD; Junbeom Park; Jin-Kyu Park; Ki-Woon Kang; Jaemin Shim; Jin-Bae Kim; Jun Kim; Eue-Keun Choi; Hyung Wook Park; Young Soo Lee; Boyoung Joung</p> <table> <tbody> <tr> <td> <p><strong>Supplementary Table 1.</strong> Subgroup analysis of primary outcome in rate- and rhythm-control group before overlap weighting.</p> </td> </tr> </tbody> </table> <table> <tbody> <tr> <td> <p><strong>Supplementary Figure 1. </strong>Cumulative incidence of primary outcome in rhythm and rate control treatment groups before overlap weighting.</p> </td> </tr> </tbody> </table> <table> <tbody> <tr> <td> <p><strong>Supplementary Figure 2. </strong>Cumulative incidence of secondary outcomes in rhythm and rate control treatment groups before overlap weighting.</p> </td> </tr> </tbody> </table>
Use of Dapagliflozin to Reduce Burden of Atrial Fibrillation in Patients Undergoing Catheter Ablation of Symptomatic Atrial Fibrillation
ClinicalTrials.gov study NCT04792190. IPD Sharing: NO. Countries: 1. Publications: 42.
A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation
ClinicalTrials.gov study NCT00523978. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Apixaban Evaluation of Interrupted Or Uninterrupted Anticoagulation for Ablation of Atrial Fibrillation
ClinicalTrials.gov study NCT02608099. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Ectopy Triggering Ganglionated Plexus Ablation to Prevent Atrial Fibrillation
ClinicalTrials.gov study NCT02487654. IPD Sharing: Not stated. Countries: 1. Publications: 1.
MINERVA: MINimizE Right Ventricular Pacing to Prevent Atrial Fibrillation and Heart Failure
ClinicalTrials.gov study NCT00262119. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation
ClinicalTrials.gov study NCT02727192. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation
ClinicalTrials.gov study NCT00489736. IPD Sharing: Not stated. Countries: 23. Publications: 2.
Evaluation of the WATCHMAN Left Atrial Appendage (LAA) Closure Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy
ClinicalTrials.gov study NCT01182441. IPD Sharing: NO. Countries: 1. Publications: 4.
A Study Exploring Two Treatment Strategies in Patients With Atrial Fibrillation Who Undergo Catheter Ablation Therapy
ClinicalTrials.gov study NCT01729871. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial
ClinicalTrials.gov study NCT00578617. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Atrial Deganglionation as a Therapy for Cardiac Surgery Patients With Atrial Fibrillation
ClinicalTrials.gov study NCT05426759. IPD Sharing: NO. Countries: 1. Publications: 0.
Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study
ClinicalTrials.gov study NCT00431834. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of Vanoxerine for Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm
ClinicalTrials.gov study NCT01691313. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Post-Marketing Surveillance of Prazaxa® on the Long-term Use in Patients With Nonvalvular Atrial Fibrillation
ClinicalTrials.gov study NCT01491178. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.