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171 results for “blood-brain barrier”
CERebrolysine Effect on Blood-brain Barrier in acUte Ischemic Stroke
ClinicalTrials.gov study NCT06078215. IPD Sharing: NO. Countries: 1. Publications: 6.
ExAblate Blood-Brain Barrier Opening for Treatment of Alzheimer's Disease
ClinicalTrials.gov study NCT03739905. IPD Sharing: NO. Countries: 1. Publications: 3.
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas
ClinicalTrials.gov study NCT03971734. IPD Sharing: NO. Countries: 1. Publications: 1.
ExAblate Blood-Brain Barrier Disruption for Glioblastoma in Patients Undergoing Standard Chemotherapy
ClinicalTrials.gov study NCT03712293. IPD Sharing: NO. Countries: 1. Publications: 2.
Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma
ClinicalTrials.gov study NCT04528680. IPD Sharing: NO. Countries: 1. Publications: 6.
(18F)FCWAY and the Blood-Brain Barrier
ClinicalTrials.gov study NCT01386476. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Safety Study of the Repeated Opening of the Blood-brain Barrier With the SonoCloud® Device to Treat Malignant Brain Tumors in Pediatric Patients
ClinicalTrials.gov study NCT05293197. IPD Sharing: NO. Countries: 1. Publications: 2.
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
ClinicalTrials.gov study NCT03366129. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigation of the Blood-brain and Blood-dura Barrier Durin Migraine Attacks Using MRI
ClinicalTrials.gov study NCT02202486. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Blood-brain Barrier Permeability Study in Adults With Meningitis
ClinicalTrials.gov study NCT02902588. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption for Treatment of Glioma
ClinicalTrials.gov study NCT03616860. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis
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Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
<p class="MsoBodyText">Music plays a more important role in our life than just being an entertainment. For example, it can be used as anti-anxiety therapy of human and animals. However, the unsafe listening of loud music triggers hearing loss in millions of young people and professional musicians (rock, jazz, and symphony orchestra) due to exposure to damaging sound levels using personal audio devices or at noisy entertainment venues including nightclubs, discotheques, bars, and concerts. Therefore, it is important to understand how loud music affects us.</p> <p class="MsoBodyText">In this pioneering study on healthy mice, we discover that loud rock music below the safety threshold causes opening of the blood-brain barrier (OBBB), which plays an vital role in protecting the brain from viruses, bacteria and toxins. We clearly demonstrate that listening loud music during 2 hrs in an intermittent adaptive regime is accompanied by delayed (1h after music exposure) and short-lasting (during 1-4 hrs) OBBB to low and high molecular weight compounds without cochlear and brain impairments. We present the systemic and molecular mechanisms responsible for music-induced OBBB. Finally, a revision of our traditional knowledge about the BBB nature and the novel strategies in optimizing of sound-mediated methods for brain drug delivery are discussed.</p>
Blood-brain barrier opening with focused ultrasound in Parkinson's disease dementia
<p><span><span><span><span><span><span><span><span><span><span><span>MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, <span><span>has been</span></span> applied for focal temporary BBB opening in patients with neurodegenerative disorders and brain tumors. MRgFUS could become a therapeutic tool for drug delivery of putative neurorestorative therapies. Treatment for Parkinson's disease with dementia (PDD) is an important unmet need. We <span><span>initiated a prospective, single-arm, non-randomized, proof-of-concept, safety and feasibility</span></span> phase I clinical trial <span><span>(NCT03608553), which is still in progress. The primary outcomes of the study were to demonstrate the safety, feasibility and reversibility of BBB disruption in PDD,</span></span> targeting the right parieto-occipito-temporal cortex where cortical pathology is foremost in this clinical state. <span><span>Changes in </span></span><span><span>β</span></span><span><span>-</span></span><span><span>amyloid burden, brain metabolism after treatments and neuropsychological assessments, were analyzed as exploratory measurements.</span></span> <span><span>Five patients were recruited from October 2018 until May 2019, and</span></span> received two <span><span>treatment</span></span> sessions separated by 2-3 weeks. <span><span>The results are set out in a descriptive manner.</span></span> Overall, this procedure was feasible and reversible with no serious clinical or radiological side effects. <span><span>We report BBB opening in the parieto-occipito-temporal junction in 8/10 treatments in 5 patients as demonstrated by gadolinium enhancement. In all cases the procedures were uneventful and no side effects were encountered associated with BBB opening.</span></span> From pre- to post-treatment, mild cognitive improvement was observed, and no major changes were detected in amyloid or fluorodeoxyglucose PET. MRgFUS-BBB opening in PDD is thus safe, reversible, and can be <span><span>performed</span></span> repeatedly. This study provides encouragement for the concept of BBB opening for drug delivery to treat dementia in PD and other neurodegenerative disorders.</span></span></span></span></span></span></span></span></span></span></span></p>
Data from: Blood-brain barrier deterioration and hippocampal gene expression in polymicrobial sepsis: an evaluation of endothelial MyD88 and the vagus nerve
Systemic infection can initiate or exacerbate central nervous system (CNS) pathology, even in the absence of overt invasion of bacteria into the CNS. Recent epidemiological studies have demonstrated that human survivors of sepsis have an increased risk of long-term neurocognitive decline. There is thus a need for improved understanding of the physiological mechanisms whereby acute sepsis affects the CNS. In particular, MyD88-dependent activation of brain microvascular endothelial cells and a resulting loss of blood-brain barrier integrity have been proposed to play an important role in the effects of systemic inflammation on the CNS. Signaling through the vagus nerve has also been considered to be an important component of CNS responses to systemic infection. Here, we demonstrate that blood-brain barrier permeabilization and hippocampal transcriptional responses during polymicrobial sepsis occur even in the absence of MyD88-dependent signaling in cerebrovascular endothelial cells. We further demonstrate that these transcriptional responses can occur without vagus nerve input. These results suggest that redundant signals mediate CNS responses in sepsis. Either endothelial or vagus nerve activation may be individually sufficient to transmit systemic inflammation to the central nervous system. Transcriptional activation in the forebrain in sepsis may be mediated by MyD88-independent endothelial mechanisms or by non-vagal neuronal pathways.
Data from: Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease
Objective: To investigate the link between BBB permeability and CBF and the relation with white matter hyperintensities (WMHs) in cerebral small vessel disease (cSVD). Methods: Twenty-seven patients with cSVD received dynamic susceptibility contrast and dynamic contrast-enhanced MRI to determine CBF and BBB permeability (expressed as leakage rate and volume), respectively. Structural MR images were segmented into normal appearing white matter (NAWM) and WMHs, for which a perilesional zone was defined. In these regions, we investigated the BBB permeability, CBF, and their relation using Pearson correlation r. Results: We found a decrease in CBF of 2.2 mL/min/100g(p<0.01) and an increase in leakage volume of 0.7%(p<0.01) per mm closer to the WMHs in the perilesional zones. Lower CBF values correlated with higher leakage measures in the NAWM and WMHs (-0.53
Blood-brain barrier opening with focused ultrasound in Parkinson’s disease dementia
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Data from: Blood-brain barrier deterioration and hippocampal gene expression in polymicrobial sepsis: an evaluation of endothelial MyD88 and the vagus nerve
Open the record for dataset details and reuse information.
Data from: Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease
Open the record for dataset details and reuse information.
Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.