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Dataset results
1,039 results for “brains stimulation”
Microelectrode register (MER) data from Deep Brain Stimulation (DBS) surgery in Parkinson's disease patients
<p>MER data consist of brain signal in different depths when DBS surgery is being done. In each depth, a data file is created, with different duration depending on the depth, and up to three channels.</p> <p>Data come from 14 patients (9 males and 5 females), they are anonymized and labelled from P1 to P14. They correspond to patients in age 65.1 +- 5.6 years.</p> <p>Data are organized in STN-IN and STN-OUT (different depths in each folder), subthalamus-in, and subthalamus-out since the STN area is the target area when implanting a DBS. Classification in STN-IN and STN-OUT was made by the neurophysiologists and surgeons.</p> <p>Data were recorded for left and right lobes, 8 patients in left and right lobe, 1 patient in right lobe, and 5 patients in left lobe.</p> <p>The format is mat file (MATLAB file)</p> <p>Data sampling frequency is 12kHz.</p> <p>No filtering or data processing was made, they are directly obtained from the MER acquisition system.</p> <p> </p>
Data for: Deep brain stimulation in early-stage Parkinson disease
<p><strong>Objective</strong>: To report 5-year outcomes from the subthalamic nucleus (STN) deep brain stimulation (DBS) in early-stage Parkinson disease (PD) pilot clinical trial.</p> <p><strong>Methods</strong>: The pilot was a prospective, single-blind clinical trial that randomized patients with early-stage PD (Hoehn & Yahr II off medications) to receive bilateral STN DBS plus optimal drug therapy (ODT) vs ODT alone (IDEG050016, NCT0282152, IRB040797). Participants who completed the 2-year trial participated in this observational follow-up study, which included annual outpatient visits through 5 years. This analysis includes 28 patients who were taking PD medications for 6 months to 4 years at enrollment. Outcomes were analyzed using both proportional odds logistic regression and linear mixed effects models.ResultsEarly STN DBS + ODT participants required lower levodopa equivalent daily doses (p = 0.04, β = −240 mg, 95% confidence interval [CI] −471 to −8) and had 0.06 times the odds of requiring polypharmacy at 5 years compared to early ODT participants (p = 0.01, odds ratio [OR] 0.06, 95% CI 0.00 to 0.65). The odds of having worse rest tremor for early STN DBS + ODT participants were 0.21 times those of early ODT participants (p < 0.001, OR 0.21, 95% CI 0.09 to 0.45). The safety profile was similar between groups.</p> <p><strong>Conclusions</strong>: These results suggest that early DBS reduces the need for and complexity of PD medications while providing long-term motor benefit over standard medical therapy. Further investigation is warranted, and the Food and Drug Administration has approved the conduct of a prospective, multicenter, pivotal clinical trial of DBS in early-stage PD (IDEG050016).</p> <p><strong>Classification of evidence</strong>: This study provides Class II evidence that DBS implanted in early-stage PD decreases the risk of disease progression and polypharmacy compared to optimal medical therapy alone.</p>
Physical Therapy and Deep Brain Stimulation in Parkinson Disease
ClinicalTrials.gov study NCT03181282. IPD Sharing: NO. Countries: 1. Publications: 1.
Tourette Syndrome Deep Brain Stimulation
ClinicalTrials.gov study NCT02056873. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation
ClinicalTrials.gov study NCT01200433. IPD Sharing: NO. Countries: 1. Publications: 1.
Non-Invasive Brain-Computer Interface Combined With Transcranial Electrical Stimulation for Peripheral Facial PalsyStimulation in the Treatment of Peripheral Facial Palsy
ClinicalTrials.gov study NCT07327710. IPD Sharing: NO. Countries: 1. Publications: 7.
Brain Stimulation For Cancer Smokers
ClinicalTrials.gov study NCT03419741. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
ClinicalTrials.gov study NCT02881151. IPD Sharing: NO. Countries: 1. Publications: 2.
Reclaim Deep Brain Stimulation Clinical Study for Treatment-Resistant Depression
ClinicalTrials.gov study NCT00837486. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial
ClinicalTrials.gov study NCT00056563. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
ClinicalTrials.gov study NCT01839396. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Improving Rehabilitation by Magnetic Brain Stimulation
ClinicalTrials.gov study NCT00636701. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Asymmetric Subthalamic Deep Brain Stimulation for Axial Motor Dysfunction in Parkinson's Disease
ClinicalTrials.gov study NCT03462082. IPD Sharing: YES. Countries: 1. Publications: 4.
Trial Comparing Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Parkinson's Disease
ClinicalTrials.gov study NCT02401308. IPD Sharing: NO. Countries: 1. Publications: 8.
Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation
ClinicalTrials.gov study NCT01958437. IPD Sharing: NO. Countries: 1. Publications: 2.
Use of Two Deep Brain Stimulation (DBS) Electrodes to Treat Post-Traumatic Tremor
ClinicalTrials.gov study NCT00954421. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
ClinicalTrials.gov study NCT06669546. IPD Sharing: NO. Countries: 1. Publications: 4.
Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder
ClinicalTrials.gov study NCT00640133. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder
ClinicalTrials.gov study NCT03950492. IPD Sharing: NO. Countries: 1. Publications: 1.
Brain Stimulation and Sensory Integration in Children With ASD
ClinicalTrials.gov study NCT07182331. IPD Sharing: YES. Countries: 1. Publications: 14.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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International Brain Laboratory public data
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OpenNeuro
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