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1,127 results for “cell cycle”
Single-particle tracking data for "CTCF sites display cell cycle dependent dynamics in factor binding and nucleosome positioning"
<p>This dataset contains all the raw SPT data reported in "­­­­CTCF sites display cell cycle dependent dynamics in factor binding and nucleosome positioning" in the form of SPT trajectories. The SPT trajectories are provided in two different formats for convenience: a CSV format and a Matlab format. Both formats are readable by Spot-On: https://spoton.berkeley.edu/</p> <p>The SPT data contains "fast tracking" spaSPT data and this data was analyzed using the Matlab version of Spot-On which can be found and downloaded at: https://gitlab.com/tjian-darzacq-lab/spot-on-matlab</p> <p> </p> <p>Full details about the Matlab and CSV formats are provided in the ReadMe files in the associated zip files.</p> <p>Please see the associated manuscript for a detailed description of how the data was acquired and analyzed.</p>
Single-cell datasets for Spherical Manifolds Capture Drug-Induced Changes in Tumor Cell Cycle Behavior
<p>Single-cell dataset for Spherical Manifolds Capture Drug-Induced Changes in Tumor Cell Cycle Behavior by Wen et al. This is a single-cell T47D ER+/HER2- cancer dataset, where rows are individual cells, and columns are proteomic features measured using iterative immunofluorescent imaging (4i). Cell cycle phase annotations are found in the 'phase' column, and the 'Metadata_well' column refers to nanomolar treatment doses of palbociclib, from an untreated population (0 nM), up to 1,000 nM. Data are z-normalized across all treatment conditions. Please refer to the manuscript for full experimental details.</p>
High-resolution mapping of the period landscape reveals polymorphism in cell cycle frequency tuning
<p>Biological oscillators adapt to environmental changes with widely tunable frequencies, a property theoretical studies attributed to positive feedbacks. However, no experiments have tested this theory. Here, we created synthetic cells to independently tune the frequency and feedback strength of a cell-cycle oscillator, enabling continuous mapping of period landscape in response to network perturbations. We found that although inhibiting positive feedback of cyclin-dependent kinase (Cdk1) reduces the tunability, the reduction is not as significant as theoretically predicted, and the Cdk1-counteracting phosphatase, PP2A, provides additional machinery to ensure frequency regulation. Additionally, cells exhibit polymorphic responses to PP2A inhibition, showing a monomodal distribution of oscillatory cells at low or high PP2A inhibition or a bimodal distribution at both low and high inhibitions. We explained the polymorphism by a model of two interlinked bistable switches of Cdk1 and PP2A where cell-cycle oscillations exhibit two modes in the presence or absence of PP2A bistability.</p>
Trained network for cell-cycle slowdown detection - DetecDiv (id03)
<pre>Trained network for cell-cycle slowdown detection. Related to the dataset: <a href="https://doi.org/10.5281/zenodo.5553796">doi.org/10.5281/zenodo.5553796</a></pre> <p><strong>------------------------------------------</strong></p> <p><strong>Author(s)</strong>: Théo, ASPERT</p> <p><strong>Contact email</strong>: theo.aspert@gmail.com</p> <p><strong>Affiliation</strong>: IGBMC, Université de Strasbourg</p> <p><strong>Funding bodies</strong>: This work was supported by the Agence Nationale pour la Recherche, the grant ANR-10-LABX-0030-INRT, a French State fund managed by the Agence Nationale de la Recherche under the frame program Investissements d'Avenir ANR-10-IDEX-0002-02.</p>
Cycling Data of 64 Cells manufactured by AutoBASS
<p>This is the complete dataset for cells made for the publication of <a href="https://doi.org/10.1039/D2DD00046F">https://doi.org/10.1039/D2DD00046F</a> </p> <p>Robotic cell assembly to accelerate battery research, <em><strong>Digital Discovery</strong></em>, 2022, Advance Article by Zhang et al.</p> <p>This dataset goes beyond the inital cycles and tested, wherever possibile, up to 500 cycles at a constant 1C/1D rate.</p> <p>The details of the robot that made the cells can be found at https://github.com/Helge-Stein-Group/AutoBASS and the details of the cycling procedure and chemistry can be found in the article.</p>
Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediat
ClinicalTrials.gov study NCT03526250. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila
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Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish
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High-resolution mapping of the period landscape reveals polymorphism in cell cycle frequency tuning
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Local nuclear to cytoplasmic ratio regulates H3.3 incorporation via cell cycle state during zygotic genome activation
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Data from: High-content phenotyping reveals Golgi dynamics and their role in cell cycle regulation
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Data from: Differences in RAD51 transcriptional response and cell cycle dynamics reveal varying sensitivity to DNA damage among Arabidopsis thaliana root cell types
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Data from: NEK4 suppresses cell proliferation in BT20 triple-negative breast cancer cells by diminishing expression of cell cycle genes, while its depletion mitigates proliferation in other cell lines
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Data from: Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint
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Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters
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Data from: Dispensability of extrinsic DnaA regulators in Escherichia coli cell-cycle control
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Quantification of cell cycle re-entry during dedifferentiation of primary adipocytes in vitro
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Data from: The non-coding RNA CcnA modulates the master cell cycle regulators CtrA and GcrA in Caulobacter crescentus
<p>Bacteria are powerful models for understanding how cells divide and accomplish global regulatory programs. In <em>Caulobacter crescentus</em>, a cascade of essential master regulators supervises the correct and sequential activation of DNA replication, cell division and development of different cell types. Among them, the response regulator CtrA plays a crucial role coordinating all those functions. Here, for the first time we describe the role of a novel factor named CcnA, a cell cycle regulated ncRNA located at the origin of replication, presumably activated by CtrA and responsible for the accumulation of CtrA itself. In addition, CcnA may be also involved in the inhibition of translation of the S-phase regulator, GcrA, by interacting with its 5' untranslated region (5'-UTR). Performing <em>in vitro</em> experiments and mutagenesis, we propose a mechanism of action of CcnA based on liberation (<em>ctrA</em>) or sequestration (<em>gcrA</em>) of their ribosome-binding site (RBS). Finally, its role may be conserved in other alphaproteobacterial species, such as <em>Sinorhizobium</em> <em>meliloti</em>, representing indeed a potentially conserved process modulating cell cycle in <em>Caulobacterales </em>and<em> Rhizobiales</em>. </p>
Single-cell TCA cycle proteomics of human embryos during early organogenesis
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Example dataset and expected outcomes of Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues
<p>Here are the example datasets and expected outcomes included in "<strong>Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues</strong>" from Ren et al. Please refer to the README.txt file for more detailed information. Corresponding computational tools are available at <a href="https://github.com/wanglab-broad/starfinder">https://github.com/wanglab-broad/starfinder.</a></p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.