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579 results for “cell death”
General dataset of PNAS article " Ca2+ permeation through C-terminal cleaved, but not full-length human Pannexin1 hemichannels, mediates cell death"
<p>This repository contains an extended version of all real-time dye uptake evaluations, Ca2+ signal measurements, microscopic and gel images, and the corresponding statistical analyzes for each graph presented in the associated article.</p>
A quantitative approach to easily characterize and predict cell death and escape to β-lactam treatments
<p>This repository contains the raw experimental data corresponding to the paper entitled "A quantitative approach to easily characterize and predict cell death and escape to β-lactam treatments" and authored by Andreani, Gross and colleagues. </p> <p>The analysis of the data and the creation of the figures of the paper can be done using the code available at https://gitlab.inria.fr/InBio/Public/esbl-escape. A README file, briefly describing data organization, is provided.</p>
Systematic spatio-temporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration
<p>Values for immuohistochemical analysis or enzymatic analysis of various markers theorised to have roles in retinal dystrophies in three models of mouse retinal degeneration with a control. Analysis has been broken down by marker, mouseline, age and region of the retina recorded from</p>
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment
<p>Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Furthermore, in neutrophils, H4K16ac was enriched at specific DNA repeats. These DNA regions presented an accessible chromatin conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed cell death. Our results thus suggest that H4K16ac plays a dual role in myeloid cells as it not only regulates differentiation and apoptosis, but it also exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neutrophil cell death.</p> <p> </p>
Diffusive Dynamics of Bacterial Proteome as a Proxy of Cell Death
<p>This dataset accompanies the article entitled <em>Diffusive Dynamics of Bacterial Proteome as a Proxy of Cell Death</em>, published in ACS Cent. Sci. (<a href="https://doi.org/10.1021/acscentsci.2c01078">https://doi.org/10.1021/acscentsci.2c01078</a>).</p> <p><strong>subboxes_overview.xlsx: </strong>This spreadsheet contains information about the protein composition of each sub-box.</p> <p><strong>BOX_GEOMETRIES.zip: </strong>Starting structures (saved in Gromos87 .gro format) used for the production runs of the all-atom sub-boxes.</p> <p><strong>PROTEIN_COM_MSD.zip: </strong>Text files containing the mean square displacements (MSDs) of the centers of mass (COMs) of individual proteins, as obtained from the production runs of the all-atom sub-boxes. The time is shown in picoseconds while the MSD values are given in nm<sup>2</sup>. For each sub-box, the protein numbering corresponds to the subboxes_overview.xlsx spreadsheet.</p> <p><strong>CHAIN_COM_MSD.zip: </strong>Text files containing the mean square displacements (MSDs) of the centers of mass (COMs) of individual polypeptide chains, as obtained from the production runs of the all-atom sub-boxes. The time is shown in picoseconds while the MSD values are given in nm<sup>2</sup>. For each sub-box, the chain numbering corresponds to the subboxes_overview.xlsx spreadsheet.</p> <p><strong>CHAIN_ROTACF.zip: </strong>Text files containing the rotational autocorrelation functions for individual polypeptide chains, as obtained from the production runs of the all-atom sub-boxes. The time is shown in picoseconds; the autocorrelation functions were calculated using a second-order Legendre polynomial. For each sub-box, the chain numbering corresponds to the subboxes_overview.xlsx spreadsheet.</p>
Effects of Single Agent Niraparib and Niraparib Plus Programmed Cell Death-1 (PD-1) Inhibitors in Non-Small Cell Lung Cancer Participants
ClinicalTrials.gov study NCT03308942. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of Atezolizumab in Participants With Programmed Death - Ligand 1 (PD-L1) Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT02031458. IPD Sharing: Not stated. Countries: 19. Publications: 2.
An Efficacy and Safety Study of a Combination of JNJ-73763989, Nucleos(t)Ide Analogs (NA), and a Programmed Cell Death Protein Receptor-1 (PD-1) Inhibitor in Chronic Hepatitis B Participants
ClinicalTrials.gov study NCT05275023. IPD Sharing: YES. Countries: 8. Publications: 0.
Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer
ClinicalTrials.gov study NCT04676412. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer
ClinicalTrials.gov study NCT03829332. IPD Sharing: YES. Countries: 19. Publications: 2.
A Study of Atezolizumab in Participants With Programmed Death-Ligand 1 (PD-L1) Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) [FIR]
ClinicalTrials.gov study NCT01846416. IPD Sharing: Not stated. Countries: 5. Publications: 1.
M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC)
ClinicalTrials.gov study NCT03631706. IPD Sharing: YES. Countries: 18. Publications: 3.
A Pilot Study of Sequential ONCOS-102, an Engineered Oncolytic Adenovirus Expressing GMCSF, and Pembrolizumab in Patients With Advanced or Unresectable Melanoma Progressing After Programmed Cell Death
ClinicalTrials.gov study NCT03003676. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Study of TSR-033 With an Anti-programmed Cell Death-1 Receptor (PD-1) in Participants With Advanced Solid Tumors
ClinicalTrials.gov study NCT03250832. IPD Sharing: NO. Countries: 2. Publications: 1.
Study of First-line Pembrolizumab (MK-3475) With Lenvatinib (MK-7902/E7080) in Urothelial Carcinoma Cisplatin-ineligible Participants Whose Tumors Express Programmed Cell Death-Ligand 1 and in Partici
ClinicalTrials.gov study NCT03898180. IPD Sharing: YES. Countries: 20. Publications: 2.
Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death
ClinicalTrials.gov study NCT00246857. IPD Sharing: NO. Countries: 2. Publications: 4.
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastat
ClinicalTrials.gov study NCT04199104. IPD Sharing: YES. Countries: 19. Publications: 1.
Data from: Response to persistent er stress in plants: a multiphasic process that transitions cells from prosurvival activities to cell death
Open the record for dataset details and reuse information.
Integrin restriction by miR-34 protects germline progenitors from cell death during aging
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Data from: Subsets of tissue CD4 T cells display different susceptibilities to HIV infection and death: Analysis by CyTOF and single cell RNA-seq
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ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.