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Dataset results
303 results for “cerebrospinal fluid”
Integrated single cell transcriptomics of cerebrospinal fluid cells in early Multiple Sclerosis
<p>h5ad file for "Integrated single cell transcriptomics of cerebrospinal fluid cells in early Multiple Sclerosis"</p>
Implementing amplified MRI in a computational fluid dynamics model of the cerebrospinal fluid
<div> <p>This folder respository contains files to implement measured amplified MRI motion into a CFD model. The files should be imported in FLUENT (Ansys Inc.) in the following order:</p> <ol> <li><strong>setup_case.jou</strong>: journal file containing the commands to setup the CFD model in FLUENT (Ansys Inc.). This file also compiles and loads the UDF <strong>mesh_motion_all_v2023.c</strong>. The UDF is directly based on the code provided in the Github respiratory (<a href="https://pyfsi.github.io/coconut/">CoCoNuT</a>). A define-on-demand function should then be executed to export the unique node ids from FLUENT. </li> <li>Run the Python file <strong>link_node_id_spline_interpolation.ipynb</strong> which returns .dat files for the different timesteps. </li> <li><strong>run_motion.jou</strong>: journal file that reads the .dat files generated in step 2 and applies the mesh motion in the CFD model.</li> </ol> </div>
Data for Sleep cycle-dependent vascular dynamics and the predicted effects on perivascular cerebrospinal fluid flow and solute transport
<p>Datasets containing derived data and results used by code in: https://github.com/AlexandraVallet/PVSflow for "Sleep cycle-dependent vascular dynamics and the predicted effects on perivascular cerebrospinal fluid flow and solute transport", Bojarskaite et al. 2023. Please see github for instructions. </p>
Data from: The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid
<p>The Reissner fiber (RF) is an acellular thread positioned in the midline of the central canal that forms together with cerebrospinal fluid (CSF)-contacting neurons (CSF-cNs) an axial sensory system detecting curvature in the spinal cord. How these components interact is unknown. Using <em>in vivo</em> imaging in larval zebrafish, we show that RF is under tension and resonates dorsoventrally. Focal RF ablations trigger retraction and relaxation of the fiber cut ends, with larger retraction speeds for rostral ablations. We built a mechanical model that estimates RF stress diffusion coefficient at 10 mm<sup>2</sup>/s and reveals that tension builds up rostrally along the fiber. After RF ablation, CSF-cN spontaneous activity decreased and ciliary motility changed, suggesting physical interactions between RF and cilia projecting into the central canal. We observed that motile cilia were caudally-tilted and frequently interacted with RF. We propose that the numerous ependymal motile monocilia contribute to RF heterogenous tension via weak interactions. Our work demonstrates that under tension, the Reissner fiber dynamically interacts with motile cilia generating CSF flow and spinal sensory neurons.</p>
PubChem lists to Study the Exposome of Mild Cognitive Impairment and Alzheimer's Disease on Cerebrospinal Fluid
<p>Collection of 4 lists of chemicals associated to Alzheimer's disease (AD) and related disorders. </p> <p>The following table describes the mentioned lists. </p> <table> <tbody> <tr> <td>Name</td> <td>Description</td> </tr> <tr> <td>AD-database</td> <td>Database of 41,917 chemicals related to AD and other neurodegenerative disorders. CIDs co-ocurring with the 27 selected MeSH terms (*see below) were merged and mapped to the parent CIDS.</td> </tr> <tr> <td>TOP1</td> <td>List of 1,268 chemicals having D000544 (AD MeSH code) as the first neighbor .</td> </tr> <tr> <td>SC20</td> <td>List of 247 chemicals created after truncating by 1/20 of the maximum co-ocurrence score of the chemical neighbors for D000544. </td> </tr> <tr> <td>AD-CTD</td> <td>List of 86 chemicals specifically related to AD in the Comparative Toxicogenomic Database (CTD)</td> </tr> </tbody> </table> <p> *Selected MeSH terms for the AD-database: D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647 and D000647.</p> <p>HMDB-CSF can be downloaded <a href="https://csfmetabolome.ca/downloads"><strong>here</strong></a>.</p> <p>PubChemLite for Exposomics (version 1.12.0) can be found <a href="https://doi.org/10.5281/zenodo.6936117"><strong>here</strong></a>.</p>
Cerebrospinal Fluid Collection and Repository Storage
ClinicalTrials.gov study NCT01862107. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Normal Tension and Chronic Open Angle Glaucoma and Cerebrospinal Fluid Composition
ClinicalTrials.gov study NCT00306657. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs
ClinicalTrials.gov study NCT01387594. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Relationship Between Protein Biomarkers in Cerebrospinal Fluid and Alzheimer&Apos;s Disease in Patients With Depression
ClinicalTrials.gov study NCT02303158. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Study Investigating the Effects of JNJ-54861911 on Amyloid-beta Processing in Cerebrospinal Fluid (CSF) and Plasma in Japanese Participants Asymptomatic at Risk for Alzheimer Dementia
ClinicalTrials.gov study NCT02360657. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Penetration of Ceftaroline Into Cerebrospinal Fluid(CSF)
ClinicalTrials.gov study NCT02806882. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neurotrophic Factors in Cerebrospinal Fluid in Diabetic Patients With Polyneuropathy
ClinicalTrials.gov study NCT01718015. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Cerebrospinal Fluid Rhinorrhea After Functional Endoscopic Sinus Surgery
ClinicalTrials.gov study NCT02382692. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Evaluate the Pharmacodynamic Effects of Single Oral Doses of PF-06648671 on β-Amyloid (Aβ) Concentrations in Cerebrospinal Fluid (CSF)
ClinicalTrials.gov study NCT02407353. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T
ClinicalTrials.gov study NCT02285348. IPD Sharing: Not stated. Countries: 1. Publications: 5.
The Role of Biomarker in Serum, Cerebrospinal Fluid and Parenchyma in the Context of Aneurysmal Subarachnoid Hemorrhage.
ClinicalTrials.gov study NCT02142166. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Prognostic Value of Biochemical Markers in Cerebrospinal Fluid for Functional Outcome of Spinal Cord Injured Patients
ClinicalTrials.gov study NCT01861808. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Cerebrospinal Fluid (CSF) Drainage and Cytokine Profiling in the Treatment of Acute Spinal Cord Injury (SCI)
ClinicalTrials.gov study NCT00135278. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Tolerability and the Effects on Cerebrospinal Fluid Spectrin Breakdown Product-145 Levels of ABT-957 in Subjects With Mild Alzheimer's Disease and Mild Cognitive Impairment
ClinicalTrials.gov study NCT02573740. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases
ClinicalTrials.gov study NCT01713699. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.