Find research datasets worth reusing

Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema

ClinicalTrials.gov study NCT02584959. IPD Sharing: YES. Countries: 7. Publications: 2.

Study of Long Term Safety and Clinical Outcomes of Idursulfase IT and Elaprase Treatment in Pediatric Participants Who Have Completed Study HGT-HIT-094

ClinicalTrials.gov study NCT02412787. IPD Sharing: YES. Countries: 7. Publications: 2.

Multinational Clinical Study Comparing Isatuximab, Carfilzomib And Dexamethasone To Carfilzomib And Dexamethasone In Relapse And/Or Refractory Multiple Myeloma Patients

ClinicalTrials.gov study NCT03275285. IPD Sharing: YES. Countries: 16. Publications: 10.

Study of Relationship Between Vedolizumab Therapeutic Drug Monitoring, Biomarkers of Inflammation and Clinical Outcomes

ClinicalTrials.gov study NCT04567628. IPD Sharing: YES. Countries: 1. Publications: 1.

LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib

ClinicalTrials.gov study NCT00680901. IPD Sharing: YES. Countries: 23. Publications: 2.

Study to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylitis

ClinicalTrials.gov study NCT02763046. IPD Sharing: YES. Countries: 1. Publications: 1.

Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabraf

ClinicalTrials.gov study NCT02124772. IPD Sharing: YES. Countries: 5. Publications: 3.

A Open-label Study Investigating the Safety and Tolerability of NPSP558, a Recombinant Human Parathyroid Hormone (rhPTH [1-84]), for the Treatment of Adults With Hypoparathyroidism - A Clinical Extens

ClinicalTrials.gov study NCT01297309. IPD Sharing: YES. Countries: 1. Publications: 5.

Clinical Effectiveness of Body Fat Distribution Imaging in Real-World Practice: The BODY-REAL Study

ClinicalTrials.gov study NCT04763772. IPD Sharing: YES. Countries: 1. Publications: 1.

Study Estimating the Clinical Difference Between 300 mg and 150 mg of Secukinumab Following Dose Escalation to 300 mg in Patients With Ankylosing Spondylitis

ClinicalTrials.gov study NCT03350815. IPD Sharing: YES. Countries: 1. Publications: 1.

opencc-by-4.0May 2020View details →

Phenotypic modulation of biofilm formation in a Staphylococcus epidermidis orthopedic clinical isolate grown under different mechanical stimuli: contribution from a combined proteomic study

One of the major causes of prosthetic joint failure is infection. Recently, coagulase negative Staphylococcus epidermidis has been identified as an emergent, nosocomial pathogen involved in subclinical prosthetic join infections (PJIs). The diagnosis of PJIs mediated by S. epidermidis is usually complex and difficulties due to the absence of acute clinical signs derived from the host immune system response. Therefore, analysis of protein patterns in biofilm-producing S. epidermidis allows for the examination of the molecular basis of biofilm formation. Thus, in the present study, the proteome of a clinical isolate S. epidermidis was analyzed when cultured in its planktonic or sessile form to examine protein expression changes depending on culture conditions. After 24 hours of culture, sessile bacteria exhibited increased gene expression for ribosomal activity and for expression of proteins related to the initial attachment phase, involved in the capsular polysaccharide/adhesin, surface associated proteins and peptidoglycan biosynthesis. Likewise, planktonic S. epidermidis was able to aggregate after 24 hours, synthesizing the accumulation associate protein and cell-wall molecules through the activation of the YycFG and ArlRS, two component regulatory pathways. Prolonged culture under vigorous agitation generated a stressful growing environment triggering aggregation in a biofilm-like matrix as a mechanism to survive harsh conditions. Further studies will be essential to support these findings in order to further delineate the complex mechanisms of biofilm formation of S. epidermidis and they could provide the groundwork for the development of new drugs against biofilm-related infections, as well as the identification of novel biomarkers of subclinical or chronic infections mediated by these emerging, low virulence pathogens.

opencc-by-4.0May 2020View details →

Dioxin Clinical Trials: Number of Studies per Condition

As of May 2020, there were 15 reported clinical trials related to “dioxin” with 8 completed and 5 active studies.  https://clinicaltrials.gov/

opencc-by-4.0Apr 2024View details →

Assessment of Self-Medication Practices and Safety Profile of Medicines Utilisation among Pregnant Women attending Antenatal Clinics in Freetown, Sierra Leone: A Multicentre Cross-Sectional Descriptive Study

Background: Despite the potential fetal and maternal risks of self-medication, studies on self-medication practice and the safety profile of medicines used during pregnancy are scarce in our setting. This study determined the self-medication practice and safety profile of medicines used among pregnant women. Methods: This cross-sectional study was conducted in face-to-face interviews among 345 pregnant women at three hospitals in Sierra Leone. Data were analyzed using descriptive statistics and binary logistic regression to determine the prevalence and associated factors of self-medication. Results: A total of 345 pregnant women participated in the study. The prevalence of self-medication among pregnant women with conventional and/or herbal medicine was 132 (38.3%). Also, 93 (75%) of the conventional medicines (CMs) were categorized as probably safe, of which paracetamol 36 (29.0%) was commonly used, followed by amoxicillin 23 (18.5%) and antimalarials 22 (17.7%) for common illnesses such as headache 30 (25.4%), urinary tract infection 23 (19.4%) and malaria 22 (18.6%). The common reason for self-medication was previous experience with the disease 24 (27.3%). Luffa acutangula 19 (30.2%) was the most used herbal medicine (HM), and Oedema 30 (47.6%) was the most reported ailment. Among the HM users, 34 (54.0%) believe they are more effective than CMs. Secondary school education (AOR = 2.128, 95%CI = 1.191 – 3.804, p = 0.011), tertiary education (AOR = 2.915, 95%CI = 1.104 – 7.693, p = 0.031), monthly income of greater than NLe 1,000 (AOR = 4.084, 95% CI = 1.269 – 13.144, p = 0.018), and perceived maternal illness (AOR = 0.367, CI = 0.213 – 0.632, p = <0.001) were predictors of self-medication. Conclusion: Self-medication practice was highly prevalent and was associated with educational status, monthly income, and maternal illness during pregnancy. Therefore, intervention programs should be designed and implemented to minimize the practice and risk associated with self-medication among pregnant women.

opencc-by-4.0Oct 2021View details →

Current clinical practice in adapted automated peritoneal dialysis (aAPD) – a prospective, non-interventional study

Dataset for the publication "Current clinical practice in adapted automated peritoneal dialysis (aAPD) – a prospective, non-interventional study"

opencc-by-4.0Feb 2022View details →

The indirect impact of COVID-19 on major clinical outcomes of people with Parkinson's disease or atypical parkinsonism: a cohort study. Raw data

Raw dataset of the study "The indirect impact of COVID-19 epidemic on major clinical outcomes of people with Parkinson’s disease (PD) or atypical parkinsonism: a cohort study"

opencc-by-4.0Feb 2022View details →

Mental health and alcohol use among patients attending a post-COVID-19 follow-up clinic: A cohort study.

Study dataset Abstract Background: Ongoing mental health problems following COVID-19 infection warrant greater examination. This study aimed to investigate psychiatric symptoms and problematic alcohol use among Long COVID patients. Methods: The study was conducted at the Mater Misericordiae University Hospital’s post-COVID-19 follow-up clinic in Dublin, Ireland. A prospective cohort study design was used encompassing assessment of patients’ outcomes at 2-4 months following an initial clinic visit (Time 1), and 7–14-month follow-up (Time 2). Outcomes regarding participants’ demographics, acute COVID-19 healthcare use, mental health, and alcohol use were examined. Results: The baseline sample’s (n = 153) median age = 43.5yrs (females = 105 (68.6%)). Sixty-seven of 153 patients (43.8%) were admitted to hospital with COVID-19, 9/67 (13.4%) were admitted to ICU, and 17/67 (25.4%) were readmitted to hospital following an initial COVID-19 stay. Sixteen of 67 (23.9%) visited a GP within seven days of hospital discharge, and 26/67 (38.8%) did so within 30 days. Seventeen of 153 participants (11.1%) had a pre-existing affective disorder. The prevalence of clinical range depression, anxiety, and PTSD scores at Time 1 and Time 2 (n = 93) ranged from 12.9% (Time 1 anxiety) to 22.6% (Time 1 PTSD). No statistically significant differences were observed between Time 1 and Time 2 depression, anxiety, and PTSD scores. Problematic alcohol use was common at Time 1 (45.5%) and significantly more so at Time 2 (71.8%). Clinical range depression, anxiety, and PTSD scores were significantly more frequent among acute COVID-19 hospital admission and GP attendance (30 days) participants, as well as among participants with lengthy ICU stays, and those with a previous affective disorder diagnosis. Conclusions: Ongoing psychiatric symptoms and problematic alcohol use in Long COVID populations are a concern and these issues may be more common among individuals with severe acute COVID-19 infection and /or pre-existing mental illness.

dryad36/100

Data from: Implementation of a pediatric telemedicine and medication delivery service in a resource-limited setting: A pilot study for clinical safety and feasibility

Objective: Determine the clinical safety and feasibility of implementing a telemedicine and medication delivery service (TMDS) to address gaps in nighttime healthcare access for children in low-resource settings. Results: A total of 391 cases were enrolled from September 9th, 2019 to January 19th, 2021; 89% (347) received a household visit. Most cases were triaged as mild or moderate (92%; 361). Among the severe cases, 83% (20) sought subsequent referred care. The most common complaint was a respiratory problem (63%; 246). At 10-days, 95% (329) of parents reported their child's condition as "improved" or "recovered". Ninety-nine percent (344) rated the TMDS as "good" or "great". The median phone consultation was 20 minutes, time to arrival at the household was 73 minutes and total workflow per case was 114 minutes. Conclusion: The TMDS was a feasible healthcare delivery model with high rates of improved clinical status at 10-days.

opencc-zeroMay 2022View details →

opencc-by-4.0Dec 2018View details →

Comparative Study of Intravenous Esmolol & Magnesium Sulphate in Attenuating Hemodynamic Response during Laryngoscopy & Endotracheal Intubation in Patients Undergoing Valvular Heart Surgery: a Randomised Clinical Trial

The present study aimed to compare the effectiveness of esmolol & magnesium sulphate in attenuating the hemodynamic response to endotracheal intubation and to note any signifi cant side effects caused by these drugs. Background: Induction with endotracheal intubation in patients undergoing valvular heart replacement pose lot of hemodynamic variations. Obtunding hemodynamic response which can be deleterious in such patients pose a challenge to the cardiac anaesthetist. We hypothesized that using esmolol as compared to magnesium sulphate will attenuate the hemodynamic response during laryngoscopy & endotracheal intubation in patients undergoing valvular heart replacement. Methods: This was a double blind, randomised, single centre, interventional, prospective study. In this study 96 patients were divided into two groups with 48 patients each (n = 48) by sealed enveloped method of randomisation. Group E received esmolol 1.5 mg/ kg i.v and Group M received magnesium sulphate 50 mg/ kg i.v each diluted in normal saline to make up a volume of 50 ml & given via infusion slowly over 5 minutes by a burette set. Hemodynamic parameters like Heart Rate (HR), Mean Arterial Pressure (MAP), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) at baseline, 5 minutes after premedication, just before intubation 3, 5, 10 & 15 minutes post intubation were recorded. The last observation at the end of 15 minutes post intubation was considered as the end of study. Results: All the enrolled patients were analyzed. The esmolol group showed a decrease in the H.R from baseline (86.13 ± 15.87) as compared to magnesium sulphate (98.51 ± 16.81 with a 95% CI, 4.62-4.69, p value < 0.001) 5 minute after premedication. There was statistically signifi cant difference in H.R between both groups 5 minutes after drug administration. Conclusion: Administration of esmolol before intubation in valvular heart patients undergoing valve replacement surgery controls the hemodynamic response much better as compared to magnesium sulphate.

opencc-by-4.0Oct 2024View details →

Assessing the feasibility and acceptability of a pre-clinic vital signs assessment in primary care: a pilot study.

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