Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
178
datasets available to search
ShareScore release 0.7.1
Dataset results
178 results for “complex disease”
Modelling the genetic aetiology of complex disease: human-mouse conservation of noncoding features and disease-associated loci
Open the record for dataset details and reuse information.
Complex feline disease mapping using a dense genotyping array
Open the record for dataset details and reuse information.
Data for: Capturing complex interactions in disease ecology with simplicial sets
Open the record for dataset details and reuse information.
Dataset - A complex network of additive and epistatic quantitative trait loci underlies natural variation of Arabidopsis thaliana quantitative disease resistance to Ralstonia solanacearum under heat stress
<p>Plant immunity is often negatively impacted by heat stress. However, the underlying molecular mechanisms remain poorly characterized. Based on a genome-wide association mapping approach, this study aims to identify in <em>Arabidopsis thaliana</em> the genetic bases of robust resistance mechanisms to the devastating pathogen<em> Ralstonia solanacearum</em> under heat stress. A local mapping population was phenotyped against the <em>R. solanacearum</em> GMI1000 strain at 27 and 30 °C. To obtain a precise description of the genetic architecture underlying natural variation of quantitative disease resistance (QDR), we applied a genome-wide local score analysis. Alongside an extensive genetic variation found in this local population at both temperatures, we observed a playful dynamics of quantitative trait loci along the infection stages. In addition, a complex genetic network of interacting loci could be detected at 30 °C. As a first step to investigate the underlying molecular mechanisms, the atypical meiotic cyclin <em>SOLO DANCERS</em> gene was validated by a reverse genetic approach as involved in QDR to <em>R. solanacearum </em>at 30 °C. In the context of climate change, the complex genetic architecture underlying QDR under heat stress in a local mapping population revealed candidate genes with diverse molecular functions.</p>
Seminar - Dr Thomas Beaney - Simplifying complexity: generating multi-resolution clusters of chronic diseases in 10 million people in England
<p>Recording of the presentation given on Wednesday 23rd October by Dr <span>Thomas</span> <span>Beaney</span> “Simplifying compl<span>e</span>xity: g<span>e</span>n<span>e</span>rating multi-r<span>e</span>solution clust<span>e</span>rs of chronic dis<span>e</span>as<span>e</span>s in 10 million p<span>e</span>opl<span>e</span> in <span>E</span>ngland”<br><br>In this talk, Tom discusses an approach for g<span>e</span>n<span>e</span>rating clust<span>e</span>rs of chronic dis<span>e</span>as<span>e</span>s in p<span>e</span>opl<span>e</span> with Multipl<span>e</span> Long-T<span>e</span>rm Conditions (MLTC), which combin<span>e</span>s natural languag<span>e</span> proc<span>e</span>ssing and n<span>e</span>twork-bas<span>e</span>d clust<span>e</span>ring. H<span>e</span> also discusses th<span>e</span> chall<span>e</span>ng<span>e</span>s of <span>e</span>valuating and using clust<span>e</span>rs in practic<span>e</span> to influ<span>e</span>nc<span>e</span>pati<span>e</span>nt car<span>e</span>.</p> <p>You can view the publication of his work here: https://www.nature.com/articles/s43856-024-00529-4</p>
Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits
<p>An evolutionary model for sex differences in disease risk posits that alleles conferring higher risk in one sex may be protective in the other. These sexually antagonistic (SA) alleles are predicted to be maintained at frequencies higher than expected under purifying selection against unconditionally deleterious alleles, but there are apparently no examples in humans. Discipline-specific terminology, rather than a genuine lack of such alleles, could explain this disparity. We undertook a two-stage review of evidence for SA polymorphisms in humans using search terms from (i) evolutionary biology and (ii) biomedicine. While the first stage returned no eligible studies, the second revealed 51 genes with sex-opposite effects, 22 increased disease risk or severity in one sex but protected the other. Those with net positive effects occurred at higher frequencies. None were referred to as SA. Our review reveals significant communication barriers to fields as a result of discipline-specific terminology.</p>
Multiscale Entropy Analysis of Retinal Signals Reveals Reduced Complexity in a Mouse Model of Alzheimer's Disease
<p>MEA recordings from wild-type and 5xFAD mice retinas used for the analyses in the manuscript "Multiscale Entropy Analysis of Retinal Signals Reveals Reduced Complexity in a Mouse Model of Alzheimer's Disease".</p>
Study of the 12-month Efficacy of Stem Cell Injection in Crohn's Disease With Complex Ano-perineal Fistula
ClinicalTrials.gov study NCT05177003. IPD Sharing: Not stated. Countries: 1. Publications: 11.
COMPLEX Registry - a Prospective COhort Study to Describe the Management and Outcomes of Patients Presenting with CompLEX and Calcified Coronary Artery Disease
ClinicalTrials.gov study NCT06075602. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the CARNEY Complex (CNC)
ClinicalTrials.gov study NCT00668291. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Correlation of Clinical Types and Complexity of Coronary Artery Disease With Patients' Metabolic Profile
ClinicalTrials.gov study NCT04580173. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
ClinicalTrials.gov study NCT00001452. IPD Sharing: Not stated. Countries: 1. Publications: 5.
The Application Value of STIC in the Diagnosis of Fetal Complex Congenital Heart Disease
ClinicalTrials.gov study NCT02970071. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS
ClinicalTrials.gov study NCT00001058. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Motor Development of Children That Have Surgery as Newborns for Complex Congenital Heart Disease
ClinicalTrials.gov study NCT02781545. IPD Sharing: YES. Countries: 1. Publications: 7.
Deciphering the Impact of Exposures From the Gut Microbiome-derived Molecular Complex in Human Health and Disease
ClinicalTrials.gov study NCT04847011. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
ClinicalTrials.gov study NCT04763200. IPD Sharing: Not stated. Countries: 7. Publications: 1.
The Optimal Strategy of Switching From Clopidogrel to Ticagrelor in Patients With Complexity of Coronary Artery Disease
ClinicalTrials.gov study NCT03577652. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intestinal Function in Neonates With Complex Congenital Heart Disease
ClinicalTrials.gov study NCT01475357. IPD Sharing: Not stated. Countries: 1. Publications: 41.
Effect of Resistance Training in Adults With Complex Congenital Heart Disease
ClinicalTrials.gov study NCT02658266. IPD Sharing: NO. Countries: 1. Publications: 5.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.