Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
363
datasets available to search
ShareScore release 0.7.1
Dataset results
363 results for “consciousness”
Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness
<p>Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor and cognitive disabilities. Recent research has shown that non-invasive brain-computer interface (BCI) technology could help assess these patients’ cognitive functions and command following abilities. 20 DOC patients participated in the study and performed 10 vibro-tactile P300 BCI sessions over 10 days with 8–12 runs each day. Vibrotactile tactors were placed on the each patient’s left and right wrists and one foot. Patients were instructed, via earbuds, to concentrate and silently count vibrotactile pulses on either their left or right wrist that presented a target stimulus and to ignore the others. Changes of the BCI classification accuracy were investigated over the 10 days. In addition, the Coma Recovery Scale-Revised (CRS-R) score was measured before and after the 10 vibro-tactile P300 sessions. In the first run, 10 patients had a classification accuracy above chance level (>12.5%). In the best run, every patient reached an accuracy ≥60%. The grand average accuracy in the first session for all patients was 40%. In the best session, the grand average accuracy was 88% and the median accuracy across all sessions was 21%. The CRS-R scores compared before and after 10 VT3 sessions for all 20 patients, are showing significant improvement (<em>p</em> = 0.024). Twelve of the twenty patients showed an improvement of 1 to 7 points in the CRS-R score after the VT3 BCI sessions (mean: 2.6). Six patients did not show a change of the CRS-R and two patients showed a decline in the score by 1 point. Every patient achieved at least 60% accuracy at least once, which indicates successful command following. This shows the importance of repeated measures when DOC patients are assessed. The improvement of the CRS-R score after the 10 VT3 sessions is an important issue for future experiments to test the possible therapeutic applications of vibro-tactile and related BCIs with a larger patient group.</p>
Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia
ClinicalTrials.gov study NCT05124704. IPD Sharing: NO. Countries: 1. Publications: 1.
Detection and Classification of Levels of Consciousness Using Parietal EEG-fNIRS During Anesthesia
ClinicalTrials.gov study NCT05112042. IPD Sharing: NO. Countries: 1. Publications: 14.
Effect of Median Nerve Electrical Stimulation Combined With Auricular Acupuncture on Consciousness Disturbance in Patients With Craniocerebral Injury
ClinicalTrials.gov study NCT07273864. IPD Sharing: NO. Countries: 1. Publications: 0.
The Influence of Age on EEG Signals and Consciousness During Anesthesia
ClinicalTrials.gov study NCT04765046. IPD Sharing: NO. Countries: 2. Publications: 12.
Amantadine + rTMS as a Neurotherapeutic for Disordered Consciousness
ClinicalTrials.gov study NCT02025439. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Prediction Model of Improvement of Disturbance of Consciousness in Patients With Hydrocephalus After Shunt Operation
ClinicalTrials.gov study NCT05237102. IPD Sharing: YES. Countries: 1. Publications: 3.
Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness (DoC)
ClinicalTrials.gov study NCT07209657. IPD Sharing: YES. Countries: 1. Publications: 3.
Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness
ClinicalTrials.gov study NCT01673126. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
ClinicalTrials.gov study NCT03814356. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vagal Nerve Stimulation to Treat Disorders of Consciousness
ClinicalTrials.gov study NCT07077135. IPD Sharing: YES. Countries: 1. Publications: 11.
UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study
ClinicalTrials.gov study NCT03284307. IPD Sharing: Not stated. Countries: 1. Publications: 4.
mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness
ClinicalTrials.gov study NCT06426602. IPD Sharing: YES. Countries: 1. Publications: 4.
The role of consciously timed movements in shaping and improving auditory timing
Open the record for dataset details and reuse information.
Larger capacity for unconscious versus conscious episodic memory
Open the record for dataset details and reuse information.
The neural activity of auditory conscious perception
Open the record for dataset details and reuse information.
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
Open the record for dataset details and reuse information.
Data from: Wisdom of the caregivers: pooling individual subjective reports to diagnose states of consciousness in brain injured patients, a monocentric prospective study
OBJECTIVES : The clinical distinction between vegetative state/unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) is a key step to elaborate a prognosis and formulate an appropriate medical plan for any patient suffering from disorders of consciousness (DoC). However, this assessment is often challenging and may require specialized expertise. In this study, we hypothesized that pooling subjective reports of the level of consciousness of a given patient across several nursing staff members can be used to clinically detect MCS. SETTING AND PARTICIPANTS : Patients referred for consciousness assessment were prospectively screened. MCS (target condition) was defined according to the best Coma Recovery Scale-Revised score (CRS-R) obtained from expert physicians (reference standard). "DoC-feeling" score was defined as the median of individual subjective reports pooled from multiple staff members during a week of hospitalisation (index test). Individual ratings were collected at the end of each shift using a 100mm visual analog scale, blinded from the reference standard. Diagnostic accuracy was evaluated using area under the receiver operating characteristic curve (AUC), sensitivity and specificity metrics. RESULTS : 692 ratings performed by 83 nursing staff members were collected from 47 patients. Twenty patients were in a UWS and 27 in a MCS. DoC-feeling scores obtained by pooling all individual ratings obtained for a given patient were significantly greater in MCS than in UWS patients (59.2 mm [IQR: 27.3-77.3] vs. 7.2 mm [IQR: 2.4-11.4]; p<0.001) yielding an AUC of 0.92 (95%CI: 0.84-0.99). CONCLUSIONS: DoC-feeling capitalizes on the expertise of nursing staff to evaluate patients' consciousness. Together with the CRS-R as well as with brain imaging, DoC-feeling might improve diagnostic and prognostic accuracy of DoC patients.
Data from: Disruption of the ascending arousal network in acute traumatic disorders of consciousness
Objective: To determine whether ascending arousal network (AAN) connectivity is reduced in patients presenting with traumatic coma. Methods: We performed high angular resolution diffusion imaging (HARDI) in 16 patients with acute severe traumatic brain injury who were comatose on admission and in 16 matched controls. We used probabilistic tractography to measure the connectivity probability (CP) of AAN axonal pathways linking the brainstem tegmentum to the hypothalamus, thalamus and basal forebrain. To assess the spatial specificity of CP differences between patients and controls, we also measured CP within four subcortical pathways outside the AAN. Results: Compared to controls, patients showed a reduction in AAN pathways connecting the brainstem tegmentum to a region of interest encompassing the hypothalamus, thalamus, and basal forebrain. Examining each pathway individually, brainstem-hypothalamus and brainstem-thalamus CPs, but not brainstem-forebrain CP, were significantly reduced in patients. Only one subcortical pathway outside the AAN showed reduced CP in patients. Conclusions: We provide initial evidence for the reduced integrity of axonal pathways linking the brainstem tegmentum to the hypothalamus and thalamus in patients presenting with traumatic coma. Our findings support current conceptual models of coma as being caused by subcortical AAN injury. AAN connectivity mapping provides an opportunity to advance the study of human coma and consciousness.
Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies
<p><strong>Aim</strong>: to assess overall clinical complexity of patients with acquired disorders of consciousness (DoC) in vegetative state/unresponsive wakefulness syndrome (VS/UWS) vs. minimally conscious state- MCS) and in different etiologies..<strong>Design:</strong> Multi-center cross-sectional observational study.<strong>Setting</strong>: 23 intensive neurorehabilitation units.<strong>Subjects</strong>: 264 patients with DoC in the post-acute phase: VS/UWS = 141, and MCS = 123 due to vascular (n = 125), traumatic (n = 83) or anoxic (n = 56) brain injury.<strong>Main Measures</strong>: Coma Recovery Scale-Revised, and Disability Rating Scale (DRS); presence of medical devices (e.g., for eating or breathing); occurrence and severity of medical complications.<strong>Results</strong>: patients in DoC, and particularly those in VS/UWS, showed severe overall clinical complexity. Anoxic patients had higher overall clinical complexity, lower level of responsiveness/consciousness, higher functional disability, and higher needs of medical devices. Vascular patients had worse premorbid clinical comorbidities. The two etiologies showed a comparable rate of MC, higher than that observed in traumatic etiology.<strong>Conclusion</strong>: overall clinical complexity is significantly higher in VS/UWS than in MCS, and in non-traumatic vs. traumatic etiology. These findings could explain the worse clinical evolution reported in anoxic and vascular etiologies and in VS/UWS patients and contribute to plan patient-tailored care and rehabilitation programmes.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.