Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,319
datasets available to search
ShareScore release 0.9.0
Dataset results
1,319 results for “crohns disease”
Single-cell RNA sequencing reveals dysregulated cellular programs in the inflamed epithelium of Crohn's disease patients.
<p><strong>Crohn’s disease (CD) is a complex inflammatory disorder of incompletely understood molecular aetiology. We generated a large single-cell RNA sequencing dataset from the terminal ileal biopsies of two independent cohorts comprising a total of 50 CD patients and 71 healthy controls. We performed transcriptomic analyses to reveal genes, cell types and mechanisms perturbed in CD, leveraging the power of the two cohorts to confirm our findings and assess replicability. In addition to mapping widespread alterations in cytokine signalling, we provide evidence of pan-epithelial upregulation of MHC class I genes and pathways in CD. Using non-negative matrix factorization we revealed intra- and inter-cellular upregulation of expression programs such as G-protein coupled receptor signalling and interferon signalling, respectively, in CD. We observed an enrichment of CD heritability among marker genes for various activated T cell types and myeloid cells, supporting a causal role for these cell-types in CD aetiology. Comparisons between our discovery and replication cohort revealed significant variation in differential gene-expression replicability across cell types. B, T and myeloid cells showed particularly poor replicability, suggesting caution should be exercised when interpreting unreplicated differential gene-expression result in these cell types. Overall, our results provide a rich resource for identifying cell-type specific biomarkers of Crohn’s disease and identifying genes, cell types and pathways that are causally and replicably associated with disease.</strong></p>
Safety and Efficacy Study of JNJ-64304500 in Participants With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov study NCT02877134. IPD Sharing: Not stated. Countries: 14. Publications: 2.
Open-Label Extension and Safety Study for Participants With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144
ClinicalTrials.gov study NCT02403323. IPD Sharing: Not stated. Countries: 33. Publications: 1.
A Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
ClinicalTrials.gov study NCT03926130. IPD Sharing: YES. Countries: 34. Publications: 7.
A Study of Real-World Outcomes of People With Crohn's Disease (CD)
ClinicalTrials.gov study NCT05056441. IPD Sharing: YES. Countries: 3. Publications: 1.
Eating Behaviour in Crohn's Disease
ClinicalTrials.gov study NCT02379117. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Study to Evaluate the Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease
ClinicalTrials.gov study NCT03077412. IPD Sharing: NO. Countries: 9. Publications: 1.
Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease
ClinicalTrials.gov study NCT00325078. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Efficacy and Safety Study of Mongersen (GED-0301) for the Treatment of Subjects With Active Crohn's Disease
ClinicalTrials.gov study NCT02596893. IPD Sharing: Not stated. Countries: 35. Publications: 2.
Abrilumab (AMG 181) in Adults With Moderate to Severe Crohn's Disease
ClinicalTrials.gov study NCT01696396. IPD Sharing: Not stated. Countries: 12. Publications: 1.
A Phase 2a Safety and Efficacy Open-Label Study of PRA023 in Subjects With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov study NCT05013905. IPD Sharing: YES. Countries: 8. Publications: 1.
Evaluation of Capsule Endoscopy in Patients With Suspected Crohn's Disease
ClinicalTrials.gov study NCT00487396. IPD Sharing: Not stated. Countries: 4. Publications: 1.
A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biolog
ClinicalTrials.gov study NCT03345849. IPD Sharing: YES. Countries: 49. Publications: 7.
The Effects of Naltrexone on Active Crohn's Disease
ClinicalTrials.gov study NCT00663117. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery
ClinicalTrials.gov study NCT00688636. IPD Sharing: Not stated. Countries: 1. Publications: 1.
VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease
ClinicalTrials.gov study NCT06257706. IPD Sharing: YES. Countries: 13. Publications: 0.
Safety Study of Entocort for Children With Crohn's Disease
ClinicalTrials.gov study NCT01444092. IPD Sharing: Not stated. Countries: 5. Publications: 1.
An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov study NCT03467958. IPD Sharing: Not stated. Countries: 49. Publications: 1.
An Open Label Safety and Tolerability Study of AIN457 in Patients With Moderate to Severe Crohn's Disease
ClinicalTrials.gov study NCT01009281. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Remission in Subjects With Crohn's Disease, 1 Year Phase
ClinicalTrials.gov study NCT00055497. IPD Sharing: Not stated. Countries: 1. Publications: 2.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.