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1,320 results for “degeneration”
Retinal proteome profiling of inherited retinal degeneration across three different mouse models suggests common drug targets in retinitis pigmentosa
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Data for: Multilayered regulation of developmentally programmed pre-anthesis tip degeneration of the barley inflorescence
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Data from: Tempo of degeneration across independently evolved nonrecombining regions
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Data from: Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer’s disease
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Data from: One and two year visual outcomes from the Moorfields age-related macular degeneration database: a retrospective cohort study and an open science resource
Objectives: To analyse treatment outcomes and share clinical data from a large, single-center, well-curated database (8174 eyes / 6664 patients with 120,756 single entries) of patients with neovascular age related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (VEGF). By making our depersonalised raw data openly available, we aim to stimulate further research in AMD, as well as setting a precedent for future work in this area. Setting: Retrospective, comparative, non-randomised electronic medical record (EMR) database cohort study of the UK Moorfields AMD database with data extracted between 2008 and 2018. Participants: Including one eye per patient, 3357 eyes/patients (61% female). Extraction criteria were ≥ 1 ranibizumab or aflibercept injection, entry of "AMD" in the diagnosis field of the EMR, and a minimum of one year of follow-up. Exclusion criteria were unknown date of first injection and treatment outside of routine clinical care at Moorfields before the first recorded injection in the database. Main outcome measures: Primary outcome measure was change in VA at one and two years from baseline as measured in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Secondary outcomes were the number of injections and predictive factors for VA gain. Results: Mean VA gain at one-year and two years were +5.5 (95%CI:5.0,6.0) and +4.9 (95%CI:4.2,5.6) letters respectively. Fifty-four percent of eyes gained ≥5 letters at two years, 63% had stable VA (±≤14 letters), forty-four percent of eyes maintained good VA (≥70 letters). Patients received a mean of 7.7 (95%CI:7.6,7.8) injections during year one and 13.0 (95%CI:12.8,13.2) injections over two years. Younger age, lower baseline VA, and more injections were associated with higher VA gain at two years. Conclusion: This study benchmarks high quality EMR study results of real life AMD treatment and promotes open science in clinical AMD research by making the underlying data publicly available.
Ectopic expression of BBS1 rescues male infertility, but not retinal degeneration, in a BBS1 mouse model
<p>Bardet-Biedl syndrome (BBS) is a rare ciliopathy for which there are no current effective treatments. BBS is a genetically heterogeneous disease, though the M390R mutation in <i>BBS1 </i>is involved in approximately 25% of all genetic diagnoses of BBS. The principle features of BBS include retinal degeneration, obesity, male infertility, polydactyly, intellectual disability, and renal abnormalities. Patients with mutations in BBS genes often present with night blindness within the first decade of life, which progresses to complete blindness. This is due to progressive loss of photoreceptor cells. Male infertility is caused by a lack of spermatozoa flagella, rendering them immobile. In this study, we have crossed the wild-type human <i>BBS1</i> gene, driven by the CAG promoter, onto the <i>Bbs1<sup>M390R/M390R </sup></i>mouse model to determine if ectopic expression of <i>BBS1</i> rescues male infertility and retinal degeneration. qRT-PCR indicates that the <i>BBS1 </i>transgene is expressed in multiple tissues throughout the mouse, with the highest expression seen in the testes, and much lower expression in the eye and hypothalamus. Immunohistochemistry of the transgene in the eye showed little if any expression in the photoreceptor outer nuclear layer. When male <i>Bbs1<sup>M30R/M390R</sup>;BBS1<sup>TG+</sup></i>mice are housed with WT females, they are able to sire offspring, indicating that the male infertility phenotype of BBS is rescued by the transgene. Using electroretinography (ERGs) to measure retinal function and optical coherence tomography to measure retinal thickness, we show that the transgene does not confer protection against retinal degeneration in <i>Bbs1<sup>M300R/M390R</sup>;BBS1<sup>TG+ </sup></i>mice.</p>
Data set for the article titled hypertension affects the treatment of wet age-related macular degeneration
<p>This is concise data set for the article titled Hypertension affects the treatment of wet age-related macular degeneration</p>
Data for Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
<p>Raw Data for publication titled Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration.</p>
Soluble endoglin as a biomarker of successful rheopheresis treatment in patients with age-related macular degeneration
<p>Anonymous dataset from all patients included in the study</p>
Comparative analysis of patient-specific aortic dissections through computational fluid dynamics suggests increased likelihood of degeneration in partially thrombosed aorta
<p>Aortic dissection is a life-threatening cardiovascular disease associated with high rates of morbidity and mortality, especially in medically under-served communities. It compromises the hemodynamics of the arteries that originate from the aorta, and its outcomes include visceral ischemia and aortic rupture in the acute phase and aneurysmatic degeneration in the chronic phase. Understanding patients’ blood flow patterns is pivotal for non-invasive evidence-based treatment as they greatly influence both the disease onset and its outcome. In this paper, we combine diagnostic imaging techniques and computational fluid dynamics to analyze the flow patterns of three aorta dissections (fully perfused, partially thrombosed, and fully thrombosed), and compare them to a healthy aorta. Besides flow kinematics, we focus on time averaged wall shear stress and oscillatory shear index that are recognized risk factors for aneurysm and rupture. Our analysis shows that partially thrombosed dissection is the most prone to false lumen degeneration. In all dissections, the arteries connected to the false lumen are generally poorly supplied with blood. Further, both true and false lumens present higher turbulence levels than the healthy aorta, and critical stagnation points. Mesh sensitivity and a thorough comparison against literature data together support the methodology robustness.</p>
Prediction and realisation of high mobility and degenerate p-type conductivity in CaCuP thin films Dataset
<p>Experimental and computational datasets for this publication, including README files. To unzip, in the command line paste the following command:</p> <blockquote> <p>tar -xzvf cacup_data_repository_v2.tar.gz</p> </blockquote> <p>And repeat the command:</p> <blockquote> <p>tar -xzvf <file.tar.gz></p> </blockquote> <p>for each necessary tar file.</p> <p>For any issues with accessibility, please email joe.willis.15@ucl.ac.uk.</p>
Gene augmentation prevents retinal degeneration in a CRISPR/Cas9-based mouse model of PRPF31 retinitis pigmentosa
<p>Mutations in <em>PRPF31</em> cause autosomal dominant retinitis pigmentosa, an untreatable form of blindness. Gene therapy is a promising treatment for <em>PRPF31</em>-retinitis pigmentosa, however, there are currently no suitable animal models in which to develop AAV-mediated gene augmentation. Here we establish <em>Prpf31</em> mutant mouse models using AAV-mediated CRISPR/Cas9 knockout, and characterize the resulting retinal degeneration phenotype. Mouse models with early-onset morphological and functional impairments like those in patients were established, providing new platforms in which to investigate pathogenetic mechanisms and develop therapeutic methods. AAV-mediated <em>PRPF31</em> gene augmentation restored the retinal structure and function in a rapidly degenerating mouse model, demonstrating the first in vivo proof-of-concept for AAV-mediated gene therapy to treat <em>PRPF31</em>-retinitis pigmentosa. AAV-CRISPR/Cas9-PRPF31 knockout constructs also mediated efficient <em>PRPF31</em> knockout in human and non-human primate retinal explants, laying a foundation for establishing non-human primate models using the method developed here.</p>
Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis
<p><span>Retinal optical coherence tomography has been identified as biomarker for disease progression in relapsing-remitting multiple sclerosis (RRMS), while the dynamics of retinal atrophy in progressive MS are less clear. We investigated retinal layer thickness changes in RRMS, </span><span>primary and secondary progressive MS (PPMS, SPMS)</span><span>, and their prognostic value for disease activity. Here, we analyzed 2651 OCT measurements of 195 RRMS, 87 SPMS, 125 PPMS patients, and 98 controls from five German MS centers after quality control. Peripapillary and macular retinal nerve fiber layer (pRNFL, mRNFL) thickness </span><span>predicted</span><span> future relapses in all MS and RRMS patients while mRNFL</span><span> and </span><span>ganglion cell-inner plexiform layer (GCIPL) </span><span>thickness predicted </span><span>future </span><span>MRI activity </span><span>in RRMS (mRNFL, GCIPL) and PPMS (GCIPL). mRNFL thickness </span><span>predicted </span><span>future disability progression </span><span>in PPMS.</span><span> </span><span>However, thickness change rates were subject to considerable amounts of measurement variability. In conclusion, retinal degeneration, most pronounced of pRNFL and GCIPL, occurs in all subtypes. Using the current state of technology, longitudinal assessments of retinal thickness may not be suitable on a single patient level.</span></p>
Data for publication: Si metasurface supporting multiple quasi-BICs for degenerate four-wave mixing
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Data from: Rewinding the ratchet: Rare recombination locally rescues neo-W degeneration and generates plateaus of sex-chromosome divergence
<p>Natural selection is less efficient in the absence of recombination. As a result, non-recombining sequences, such as sex chromosomes, tend to degenerate over time. Although the outcomes of recombination arrest are typically observed after many millions of generations, recent neo-sex chromosomes can give insight into the early stages of this process. Here we investigate the evolution of neo-sex chromosomes in the Spanish marbled white butterfly, <em>Melanargia ines</em>, where a Z-autosome fusion has turned the homologous autosome into a non-recombining neo-W chromosome. We show that these neo-sex chromosomes are likely limited to the Iberian population of <em>M. ines</em>, and that they arose around the time when this population split from North-African populations, around 1.5 million years ago. Recombination arrest of the neo-W chromosome has led to an excess of premature stop codons and frameshift mutations, and reduced gene expression compared to the neo-Z chromosome. Surprisingly, we identified two regions of 1 Mb at one end of the neo-W that are both less diverged from the neo-Z and less degraded than the rest of the chromosome, suggesting a history of rare but repeated genetic exchange between the two neo-sex chromosomes. These plateaus of neo-sex chromosome divergence suggest that neo-W degradation can be locally reversed by rare recombination between neo-W and neo-Z chromosomes.</p>
Systematic spatio-temporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration
<p>Values for immuohistochemical analysis or enzymatic analysis of various markers theorised to have roles in retinal dystrophies in three models of mouse retinal degeneration with a control. Analysis has been broken down by marker, mouseline, age and region of the retina recorded from</p>
Formation of Black Hole X-Ray Binaries with Non-degenerate Donors in Globular Clusters
<p>MESA inlists associated with <a href="https://ui.adsabs.harvard.edu/?#abs/2017ApJ...843L..30I">Formation of Black Hole X-Ray Binaries with Non-degenerate Donors in Globular Clusters</a></p>
Stimulated magnon scattering by non-degenerate parametric excitation: Figure data
<p>This repository contains the data displayed in the five figures of the paper:</p> <p><strong>Stimulated magnon scattering by non-degenerate parametric excitation</strong><br><em>Joo-Von Kim, Hugo Merbouche</em><br><a href="https://doi.org/10.1063/5.0223157">doi:10.1063/5.0223157</a></p> <p>We used the scientific color maps developed by Crameri <em>et al</em>. (<a href="https://doi.org/10.5281/zenodo.8409685">doi:10.5281/zenodo.8409685</a>, <a href="https://doi.org/10.1038/s41467-020-19160-7">doi:10.1038/s41467-020-19160-7</a>), namely <code>batlowW</code>, <code>oslo</code>, and <code>vik</code>, in order to minimize visual distortion of the data and artifacts for readers with color-vision deficiencies.</p> <p>Data were visualized using <a href="https://veusz.github.io">Veusz</a> and <a href="https://www.wolfram.com/mathematica/">Wolfram Mathematica</a> (v14.0), and assembled with <a href="https://affinity.serif.com/designer/">Affinity Designer</a> (v2.0).</p> <p>Mode profiles [as presented in Fig. 2(a) of the paper] are provided in the <a href="https://math.nist.gov/oommf/doc/userguide12b4/userguide/OVF_2.0_format.html">OOMMF OVF 2.0</a> format.</p>
The Regulation of Microglia Activity and the Production of IL-1α and IL-6 in the Degenerated Retina by Mesenchymal Stem Cells
<p><span>Activation of immune response and production of proinflammatory factors plays an important role in the development and progression of retinal degenerative diseases (RDD). For this reason, focusing on immunomodulation is potential option for the efficient ophthalmological therapy. Mesenchymal stem cells (MSCs) have been study in the treatment of RDD mainly due to their regenerative and neuroprotective actions. Nevertheless, MSCs also possess several immunomodulatory properties. Our study shows that NaIO<sub>3</sub>-induced degeneration increased <em>in vitro</em> and <em>in vivo</em> expression of genes for Interleukin (IL)-1α and IL-6 in the mouse retinal tissue. In addition, intraperitoneal application of NaIO<sub>3</sub> increased expression of gene for Iba-1 and infiltration of CD45<sup>+</sup>CD11b<sup>+</sup> cells into the retina. CD45<sup>+</sup> population was also responsible for the production of IL-1α while IL-6 was produced by CD45<sup>-</sup> cells. Cocultivation of degenerated retina in the presence of MSCs decreased the expression and production of both studied cytokines and expression of gene for Iba-1 in the retinal tissue. On contrary, it was observed that MSCs treated with supernatant from degenerated retina increased the expression of genes for cyclooxygenase-2, transforming growth factor-β, programmed-death ligand 1 and nerve growth factor. These results show that MSCs are able to regulate immune reaction in the degenerated retinal environment.</span></p>
Data for "Observation of a Superradiant Quantum Phase Transition in an Intracavity Degenerate Fermi Gas"
<p>This dataset is corresponding to the article "Observation of Superradiant Quantum Phase Transition in an Intracavity Degenerate Fermi Gas".</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.