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322 results for “dopaminergic”
PET Study Examining the Dopaminergic Activity of Armodafinil in Adults
ClinicalTrials.gov study NCT00592943. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dopaminergic Enhancement of Rehabilitation Therapy Early After Stroke
ClinicalTrials.gov study NCT05369533. IPD Sharing: YES. Countries: 1. Publications: 7.
The ion channel mechanisms of the subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the depression-like behavior
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An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans
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A pair of dopaminergic neurons DAN-c1 mediate Drosophila larval aversive olfactory learning through D2-like receptors
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Developmental dieldrin exposure alters DNA methylation at genes related to dopaminergic neuron development and Parkinson’s disease in mouse midbrain
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Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity
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Data from: Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence
BACKGROUND: Heroin dependence is a debilitating psychiatric disorder with complex inheritance. Since the dopaminergic system has a key role in rewarding mechanism of the brain, which is directly or indirectly targeted by most drugs of abuse, we focus on the effects and interactions among dopaminergic gene variants. OBJECTIVE: To study the potential association between allelic variants of dopamine D2 receptor (DRD2), ANKK1 (ankyrin repeat and kinase domain containing 1), dopamine D4 receptor (DRD4), Catechol-O-methyl transferase (COMT) and dopamine transporter (SLC6A3) genes and heroin dependence in Hungarian patients. METHODS: 303 heroin dependent subjects and 555 healthy controls were genotyped for 7 single nucleotide polymorphisms (SNPs): rs4680 of the COMT gene; rs1079597 and rs1800498 of the DRD2 gene; rs1800497 of the ANKK1 gene; rs1800955, rs936462 and rs747302 of the DRD4 gene. Four variable number of tandem repeats (VNTRs) were also genotyped: 120 bp duplication and 48 bp VNTR in exon 3 of DRD4 and 40 bp VNTR and intron 8 VNTR of SLC6A3. We also provide a multivariate model for the associations among them implying Bayesian networks in Bayesian multilevel analysis. FINDINGS AND CONCLUSIONS: In single marker analysis the TaqIA (rs1800497) and TaqIB (rs1079597) variants were associated with heroin dependence. Moreover, -521 C/T SNP (rs1800955) of the DRD4 gene showed nominal association with a possible protective effect of the C allele. After applying the Bonferroni correction TaqIB was still significant suggesting that the minor (A) allele of the TaqIB SNP is a risk component in the genetic background of heroin dependence. The findings of the additional multiple marker analysis are consistent with the results of the single marker analysis, but this method was able to reveal an indirect effect of a promoter polymorphism (rs936462) of the DRD4 gene and this effect is mediated through the -521 C/T (rs1800955) polymorphism in the promoter.
Medial prefrontal cortex and anteromedial thalamus interaction regulates motivation related behavior and dopaminergic neuron activity: fMRI: Rats
<p>Rat fMRI activation images supplementing for Fig. 3d and Suppl. Fig. 5.</p>
Medial prefrontal cortex and anteromedial thalamus interaction regulates motivation related behavior and dopaminergic neuron activity: fMRI: Human
<p>Human fMRI activation images supplementing for Fig. 8 and Suppl. Fig. 11.</p>
Protein aggregation and calcium dysregulation are the earliest hallmarks of familial Parkinson's disease in human midbrain dopaminergic neurons
<p>Mutations in the <em>SNCA</em> gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an <em>SNCA</em> mutation during development, to end stage pathology is unknown. Utilising human induced pluripotent stem cells (hiPSCs), we resolved the temporal sequence of SNCA induced pathophysiological events in order to discover early, and likely causative, events. Our small molecule-based protocol generates highly enriched midbrain dopaminergic (mDA) neurons: molecular identity was confirmed using single-cell RNA sequencing and proteomics, and functional identity through dopamine synthesis, and measures of electrophysiological activity. At the earliest stage of differentiation, prior to maturation to mDA neurons, we demonstrate the initial formation of small β-sheet rich oligomeric aggregates, in <em>SNCA</em>-mutant cultures. Aggregation persists and progresses, ultimately resulting in the accumulation of phosphorylated aggregates. Impaired intracellular calcium signalling, increased basal calcium, and impairments in mitochondrial calcium handling occurred early at day 34-41 post differentiation. Once midbrain identity fully developed, at day 48-62 post differentiation, <em>SNCA</em>-mutant neurons exhibited mitochondrial dysfunction, oxidative stress, lysosomal swelling and increased autophagy. Ultimately these multiple cellular stresses lead to abnormal excitability, altered neuronal activity, and cell death. Our differentiation paradigm generates an efficient model for studying disease mechanisms in PD, and highlights that protein misfolding to generate intraneuronal oligomers is one of the earliest critical events driving disease in human neurons, rather than a late-stage hallmark of the disease.</p>
Functional efficacy of the MAO-B inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: a comparative study with tranylcypromine
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Data and Images for Tonic dendritic GABA release by substantia nigra dopaminergic neurons
<p>Figure1_data.xlsx</p> <p>Numerical data for the charts in Figure 1C and Figure 1E</p> <p><br>Figure1A_GP.tif</p> <p>Fluorescent image (red channel, Chronos) for Figure 1A. </p> <p><br>Figure2_data.xlsx</p> <p>Numerical data for the charts in Figure 2B and Figure 2C</p> <p><br>Figure3_data.xlsx</p> <p>Numerical data for the charts in Figure 3A, 3B, and 3C.</p> <p><br>Figure4_data.xlsx</p> <p>Numerical data for the charts in Figure 4A and 4B.</p> <p><br>Figure5_data.xlsx</p> <p>Numerical data for the charts in Figure 5B and 5C.</p> <p><br>Figure6_data.xlsx</p> <p>Numerical data for the charts in Figure 6D, 6E, 6F, 6G and 6H.</p> <p> </p> <p>Figure6A_ALDH_Positive.tif</p> <p>DAT-Cre positive, ALDH1A1 positive axons of SNc neurons in Rostral SNr. </p> <p><br>Figure6A_ALDH_Negative.tif</p> <p>DAT-Cre positive, ALDH1A1 negative axons of SNc neurons in Rostral SNr.</p> <p><br>Figure6B_ALDH_Positive.tif</p> <p>DAT-Cre positive, ALDH1A1 positive axons of SNc neurons in Caudal SNr. </p> <p><br>Figure6B_ALDH_Negative.tif</p> <p>DAT-Cre positive, ALDH1A1 negative axons of SNc neurons in Caudal SNr.</p> <p><br>Figure6C_shRNA.tif</p> <p>Fluorescent image (red channel: ALDH_shRNA) for Figure 6C.</p> <p><br>Figure7_data.xlsx</p> <p>Numerical data for the charts in Figure 7D and 7E.</p> <p><br>Figure7A_10x.tif</p> <p>Confocal image (red channel: PSAM_FusionRed; green channel: anti-TH) for Figure 7A.</p> <p><br>Figure7B_60x.tif</p> <p>Confocal image (red channel: PSAM_FusionRed; green channel: anti-TH) for Figure 7B. </p> <p><br>Figure8_data.xlsx</p> <p>Numerical data for the charts in Figure 8A and 8B. </p> <p> </p> <p>Figure_S1_data.xlsx</p> <p>Numerical data for the chart in Figure S1</p> <p><br>Figure_S2_data.xlsx</p> <p>Numerical data for charts in Figure S2 C - E</p>
Cortical dopaminergic signaling mediates planning of directional movements
<p>Dataset for <strong>Cortical dopaminergic signaling mediates planning of directional movements.</strong></p> <p>Code for analysis is available on: <a href="https://github.com/fontaninilab/Chen.EtAl.2024">https://github.com/fontaninilab/Chen.EtAl.2024</a></p> <p>Please send correspondence for access. </p> <p>Correspondence: john.chen.3@stonybrook.edu, alfredo.fontanini@stonybrook.edu</p>
Data from: Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron
Most neurogenesis in the mammalian brain is completed embryonically, but in certain areas the production of neurons continues throughout postnatal life. The functional properties of mature postnatally-generated neurons often match those of their embryonically-produced counterparts. However, we show here that in the olfactory bulb (OB), embryonic and postnatal neurogenesis produce functionally distinct subpopulations of dopaminergic (DA) neurons. We define two subclasses of OB DA neuron by the presence or absence of a key subcellular specialisation: the axon initial segment (AIS). Large AIS-positive axon-bearing DA neurons are exclusively produced during early embryonic stages, leaving small anaxonic AIS-negative cells as the only DA subtype generated via adult neurogenesis. These populations are functionally distinct: large DA cells are more excitable, yet display weaker and - for certain long-latency or inhibitory events - more broadly-tuned responses to odorant stimuli. Embryonic and postnatal neurogenesis can therefore generate distinct neuronal subclasses, placing important constraints on the functional roles of adult-born neurons in sensory processing.
Human Embryonic Stem C ells-derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Mon-keys Recover Dopamine Levels and Motor Behavior
<p>Supplementary videos of the article "Human Embryonic Stem Cells-derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Mon-keys Recover Dopamine Levels and Motor Behavior"</p>
Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways
<p>Data for making main and supplementary figures from 'Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways'. The figure (and the corresponding subplot) is specified in each file.</p> <p>In the behavior folder, each row corresponds to one recording session.</p> <p>In the neuronal activity data, each row correspond to one neuron.</p> <p>In the dLight data, each row corresponds to one recording session.</p>
Study of the Effects of Dopaminergic Medications on Dopamine Transporter Density in Subjects With Parkinson's Disease
ClinicalTrials.gov study NCT00129181. IPD Sharing: Not stated. Countries: 4. Publications: 17.
Study of the Effects of Dopaminergic Medications on Dopamine Transporter Imaging in Parkinson's Disease
ClinicalTrials.gov study NCT00096720. IPD Sharing: Not stated. Countries: 1. Publications: 17.
Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia
ClinicalTrials.gov study NCT00111371. IPD Sharing: Not stated. Countries: 1. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.