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213
datasets available to search
ShareScore release 0.9.0
Dataset results
213 results for “drug screening”
Screening of Susceptibility Genes for APAP Induced Drug Induced LIver Injury in ChiNese Population: a Case-control Study
ClinicalTrials.gov study NCT04964310. IPD Sharing: NO. Countries: 1. Publications: 8.
Comprehensive Genomic Profiling and Next Generation Functional Drug Screening for Patients With Aggressive Haematological Malignancies
ClinicalTrials.gov study NCT04470947. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Venetoclax in Combination With Azacytidine in AML Patients Selected Using Ex Vivo Drug Sensitivity Screening
ClinicalTrials.gov study NCT04267081. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures
ClinicalTrials.gov study NCT05361603. IPD Sharing: NO. Countries: 1. Publications: 9.
Guiding Instillation in Non Muscle-invasive Bladder Cancer Based on Drug Screens in Patient Derived Organoids
ClinicalTrials.gov study NCT05024734. IPD Sharing: YES. Countries: 1. Publications: 1.
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A
ClinicalTrials.gov study NCT02095288. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer
ClinicalTrials.gov study NCT06482086. IPD Sharing: NO. Countries: 1. Publications: 1.
HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions
ClinicalTrials.gov study NCT03184597. IPD Sharing: YES. Countries: 1. Publications: 7.
Assessing Screening Plus Brief Intervention's Resulting Efficacy (ASPIRE) to Stop Drug Use
ClinicalTrials.gov study NCT00876941. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development
ClinicalTrials.gov study NCT00340522. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Screening, Brief Intervention, and Referral to Treatment for Drug Use
ClinicalTrials.gov study NCT01683227. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Screening for Youth Alcohol and Drug Use: A Study of Primary Care Providers
ClinicalTrials.gov study NCT02408952. IPD Sharing: Not stated. Countries: 1. Publications: 135.
MicroOrganoSphere (MOS) Drug Screen Pilot Trial in Colorectal Cancer
ClinicalTrials.gov study NCT05189171. IPD Sharing: NO. Countries: 1. Publications: 32.
Tissue Collection for Drug Screening and Bioanalysis
ClinicalTrials.gov study NCT04852354. IPD Sharing: NO. Countries: 1. Publications: 1.
Human Myeloma Cell Line (HMCL) NCATS MIPE 4.0 Drug Screen Dataset
<h3>Abstract</h3> <p>Multiple myeloma, a hematopoietic malignancy of terminally differentiated B cells, is the second most common hematological malignancy after leukemia. While patients have benefited from numerous advances in treatment in recent years resulting in significant increases to average survival time following diagnosis, myeloma remains incurable and relapse is common. To help identify novel therapeutic agents with efficacy against the disease and to search for biomarkers associated with differential response to treatment, a large-scale pharmacological screen was performed with 1,912 small molecule compounds tested at 11 doses for 47 human myeloma cell lines (HMCL). Raw and processed versions of the drug screen dataset are provided, as well as supportive information including drug and cell line metadata and high-level characterization of the most salient features of each. The dataset is publicly available at Zenodo and the workflow code used for data processing and generation of supporting figures and tables can be found at https://github.com/khughitt/hmcl-drug-screen-pipeline.</p> <h3>Overview</h3> <p>The dataset shared here contains the raw and processed versions of a high throughput small molecule screening dataset, as as supporting tables and figures.</p> <p>The computational pipeline used to generate the dataset is available at: <a href="https://github.com/khughitt/hmcl-drug-screen-pipeline">https://github.com/khughitt/hmcl-drug-screen-pipeline</a></p> <h3>Data organization</h3> <p>The .zip file available on Zenodo contains the complete output from the computational pipeline linked to above.</p> <p>Data and figures are organized into subfolders relating to the various pipeline steps.</p> <p>Files & folders:</p> <table> <tbody> <tr> <td><strong>drugs/</strong></td> <td>Drug curves, cell line x drug AC-50 matrix, and drug metadata tables.</td> </tr> <tr> <td><strong>manuscript/</strong></td> <td>Figures and tables generated by the pipeline for the manuscript, including the harmonized cell line metadata table ("table1.tsv")</td> </tr> <tr> <td><strong>mutations/</strong></td> <td> <p>Cell line mutation predictions with identifiers harmonized to match those used in the drug screen (source: <a href="https://www.keatslab.org/data-repository">Keats Lab</a>)</p> </td> </tr> <tr> <td><strong>plates/</strong></td> <td> <p>Drug screen viability measurements at different levels of processing, arranged with one column per plate ("raw.tsv", "raw_filtered.tsv", "normed.tsv", "background_adjusted.tsv"), plate-level metadata ("metadata.tsv"), the compued background plate ("background.tsv"), and plate images used for QA.</p> </td> </tr> <tr> <td><strong>raw/</strong></td> <td>Raw version of the drug screen dataset, including the data for cell lines which were filtered out in the pipeline due to quality purposes</td> </tr> <tr> <td><strong>datapackage.yml</strong></td> <td> <p>Metadata for the provided data resources including sha256 checksums, human-readible descriptions, column types, etc. (see: <a href="datapackage.org">https://datapackage.org/</a>)</p> </td> </tr> </tbody> </table> <p> </p>
GeCKO_v2_CRISPR_drug screens in K562 cells
<p>The data contain raw DNA deep sequencing files for GeCKO-v2 genome scale transduced K562 screens with selected drugs (imatinib, dasatinib, asciminib, tivozanib, AZD1775, mepacrine). For all drug except mepacrine the drug, day 0 and day 17 control samples' files are provided. For mepacrine which was screened separately, a triplicate drug, D15 control sample files are provided. The dates are indicated in the file names. </p>
Fig. 2 in Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold
Fig. 2. Key COSY, HMBC and ROESY correlations of analogue 5.
Implementing Screening for Cannabis and Other Drug Use Disorders in Primary Care: Impact on Diagnosis and Treatment
ClinicalTrials.gov study NCT06249542. IPD Sharing: NO. Countries: 0. Publications: 2.
Screening for Hepatitis c in People Who Inject Drugs in Armenia-Colombia
ClinicalTrials.gov study NCT06463912. IPD Sharing: NO. Countries: 1. Publications: 0.
Drug Screening Using Novel IMD in Renal Cell Carcinoma
ClinicalTrials.gov study NCT05700461. IPD Sharing: YES. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.