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146
datasets available to search
ShareScore release 0.9.0
Dataset results
146 results for “dysbiosis”
PreventiOn of DYSbioSis Complications With Autologous FMT in AML Patients
ClinicalTrials.gov study NCT02928523. IPD Sharing: NO. Countries: 1. Publications: 1.
Gut Microbiome Dysbiosis in Sepsis-induced Coagulopathy
ClinicalTrials.gov study NCT04525677. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis
ClinicalTrials.gov study NCT03569904. IPD Sharing: NO. Countries: 1. Publications: 14.
The Role of Dysbiosis of Gut Microbiota in the Pathogenesis of PCOS.
ClinicalTrials.gov study NCT03843736. IPD Sharing: NO. Countries: 1. Publications: 5.
Impact of Bread Diet on Intestinal Dysbiosis and Irritable Bowel Syndrome Symptoms in Quiescent Ulcerative Colitis
ClinicalTrials.gov study NCT05656391. IPD Sharing: NO. Countries: 1. Publications: 1.
Oral Microbiota Dysbiosis in IBD
ClinicalTrials.gov study NCT06980818. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Moderate Continuous Versus High Interval Intensity Training on Gut Dysbiosis and GLP1 Hormone in IBS
ClinicalTrials.gov study NCT06408610. IPD Sharing: YES. Countries: 1. Publications: 26.
The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis
ClinicalTrials.gov study NCT04853212. IPD Sharing: NO. Countries: 1. Publications: 2.
Intestinal Microbial Dysbiosis in Chinese Infants With Short Bowel Syndrome With Different Complications
ClinicalTrials.gov study NCT02699320. IPD Sharing: NO. Countries: 1. Publications: 27.
Effects of a Composition on the Oral Microbiome, pH, Nitrite/Nitrate Ratio, Elastases and Inflammation in Oral Dysbiosis
ClinicalTrials.gov study NCT05463484. IPD Sharing: NO. Countries: 1. Publications: 5.
Targeting the Gut Dysbiosis to Treat Inflammation-driven Synaptopathy in MS
ClinicalTrials.gov study NCT05779449. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention
ClinicalTrials.gov study NCT06005298. IPD Sharing: NO. Countries: 1. Publications: 9.
Postbiotics for Mitigation of Postoperative Dysbiosis in Gastrointestinal Cancer Surgery
ClinicalTrials.gov study NCT07050485. IPD Sharing: NO. Countries: 1. Publications: 12.
Dysbiosis individualizes fitness effect of antibiotic resistance in the mammalian gut
Open the record for dataset details and reuse information.
Early life exposure to environmental contaminants (BDE-47, TBBPA, and BPS) produced persistent gut dysbiosis in adult male mice
<p><span>The gut microbiome is a pivotal player in toxicological responses. We investigated the effects of maternal exposure to 3 human health-relevant toxicants (BDE-47, TBBPA, and BPS) on the composition and metabolite levels (bile acids [BAs] and short chain fatty acids [SCFAs]) of the gut microbiome in adult pups. CD-1 mouse dams were orally exposed to vehicle (corn oil, 10ml/kg), BDE-47 (0.2 mg/kg), TBBPA (0.2 mg/kg), or BPS (0.2 mg/kg) once daily from gestational day 8 to the end of lactation (postnatal day 21). 16S rRNA sequencing and targeted metabolomics were performed in fecal DNA of 12-week-old adult male pups (n=14-23/group). BPS had the most prominent effect on the beta-diversity of the fecal microbiome compared to TBPPA and BDE-47 (QIIME). Seventy-three taxa were persistently altered by at least 1 chemical, and 12 taxa were commonly regulated by all chemicals (most of which were from the <i>Clostridia</i> class and were decreased). The most distinct microbial biomarkers were <i>S24-7</i> for BDE-47,<i> Rikenellaceae </i>for TBPPA, and <i>Lactobacillus</i> for BPS (LefSe). The community-wide contributions to the shift in microbial pathways were predicted using FishTaco. Fecal BA output was persistently increased by all chemicals (LC-MS). TBBPA increased propionic acid and succinate, whereas BPS decreased acetic acid (GC-MS. In conclusion, maternal exposure to these toxicants persistently modified fecal microbiome and metabolites later in life, and dysbiosis may contribute to the mechanisms of developmental origins of adult-onset of toxic outcomes. </span></p>
Gut dysbiosis and mortality in hemodialysis patients
<p>Gut dysbiosis, characterized by decreased microbial diversity, promotes inflammation. Persistent inflammation plays a pathogenic role in complications of chronic kidney disease (CKD). However, little is known about the relationship between gut dysbiosis and adverse outcomes in patients with CKD. First, we examined the association of microbial diversity with all-cause mortality in CKD patients receiving hemodialysis (n=109). The microbial composition of fecal samples was profiled by means of 16S ribosomal RNA gene sequencing. Microbial diversity was calculated using the Simpson index. Participants were stratified into higher- (above the median) and lower-diversity (below the median) groups and were followed up for a median of 2.1 years. Kaplan-Meier analyses revealed a significant association between higher diversity and a lower risk of death (log-rank P=0.015). After adjustment for patient characteristics and comorbid conditions, the risk of death among patients with higher diversity was 74% lower than that among patients with lower diversity (hazard ratio, 0.26; 95% CI, 0.07 to 0.95). Next, in a matched case-control study, we compared the microbial composition between nonsurvivors and survivors who were matched 1:4 for age and sex. We observed significantly lower values of microbial diversity and higher levels of proinflammatory cytokines among nonsurvivors (n=14) than survivors (n=56). Specifically, the relative abundance of Succinivibrio and Anaerostipes, two short-chain fatty acid-producing bacteria, was markedly reduced in nonsurvivors compared with survivors. In conclusion, a unique gut microbial composition is associated with an increased risk of mortality among hemodialysis patients and may be used to identify subjects with a poor prognosis.</p>
Gut Microbiota Dysbiosis in Opioid Use Disorders: Implications for Clinical Symptoms and Relapse Rate.
ClinicalTrials.gov study NCT06231849. IPD Sharing: UNDECIDED. Countries: 0. Publications: 3.
Dysbiosis in Localized Provoked Vulvodynia (LPV)
ClinicalTrials.gov study NCT02393911. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Gut Microbiota Dysbiosis in Lupus Nephritis
ClinicalTrials.gov study NCT06231303. IPD Sharing: NO. Countries: 0. Publications: 1.
Fecal Microbiota Transplantation for Treatment of Gastrointestinal Dysbiosis or Clearance of ARO
ClinicalTrials.gov study NCT03834051. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.